Method for measuring nonlinear parameters of ultrasonic contrast agent

An ultrasonic contrast agent and parameter measurement technology, applied in ultrasonic/sonic/infrasonic diagnosis, sonic diagnosis, infrasonic diagnosis, etc., can solve problems such as instability, and achieve the effects of easy data, strong repeatability, and convenient measurement

Inactive Publication Date: 2018-06-19
CHINA JILIANG UNIV
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Problems solved by technology

In view of the fact that the existing finite amplitude method is only suitable for near-field measurement, a measurement method that can avoid the instability caused by the fluctuation of sound pressure amplitude in near-field measurement and reduce the distance detection error is proposed: using limited Measurement of nonlinear parameters of degassed water and microbubble water medium containing ultrasonic contrast agent under the action of fundamental wave and multiple harmonics after amplitude comparison method and corrected acoustic wave attenuation coefficient

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  • Method for measuring nonlinear parameters of ultrasonic contrast agent
  • Method for measuring nonlinear parameters of ultrasonic contrast agent
  • Method for measuring nonlinear parameters of ultrasonic contrast agent

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[0051] Below in conjunction with accompanying drawing, the present invention is further described:

[0052] like figure 1 As shown, the burst sinusoidal pulse signal generated by the signal generator 1 is connected to the external trigger of the digital oscilloscope 7 as a synchronization signal, which is used to capture the sound pressure waveform and calculate the plane piston transducer 3 and the thin film hydrophone 6 (the sensitivity curve is very Smooth, good frequency response, such as figure 2 At the same time, the plane piston transducer 3 ( The center frequency is 2.3MHz and the diameter is 30mm) to emit sound waves, forming a radiation sound field 9 in the water tank. The film hydrophone 6 acts as a receiving device to convert the received sound signal into an electrical signal, which is displayed on the digital oscilloscope 7 . The thin-film hydrophone 6 is installed on the high-precision three-dimensional ultrasonic scanning control mechanism 5 , and the motion...

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Abstract

The invention relates to a method for measuring nonlinear parameters of an ultrasonic contrast agent. According to the principle of the method, the ultrasonic contrast agent is added in an aqueous medium for micro bubbles, and the micro bubbles change the physical properties of the aqueous medium to cause a significant change in the measured sound pressure amplitude, so that the nonlinear parameters are changed, and the changing situation of the nonlinear parameters is estimated by measuring the change of the sound pressure amplitude. The measuring method is suitable for measuring the nonlinear parameters of a plurality of ultrasonic contrast agents, measurement is convenient, repeatability is strong, and data is easy to obtain and process, second-order nonlinear parameters can be measured, and third-order and high-order nonlinear parameters can also be measured.

Description

technical field [0001] The invention belongs to the combination of ultrasonic medical treatment and acoustic technology, and in particular relates to a method for measuring nonlinear parameters of ultrasonic contrast agents. Background technique [0002] In recent years, in the field of clinical medical ultrasound diagnosis and biological tissue imaging, microbubble ultrasound contrast agents have received more and more attention, and ultrasound technology has also been applied to a variety of therapeutic equipment. The nonlinear vibration and scattering characteristics generated when the microbubbles are excited by sound waves can improve the efficiency of ultrasonic therapy and implement intravascular thrombolytic therapy. Therefore, the combination of microbubbles and ultrasound for the treatment of some major diseases has become one of the hot spots of domestic and foreign medical circles. [0003] When the sound wave propagates in the medium, the forced vibration of th...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B8/00
CPCA61B8/481A61B8/5207
Inventor 兰庆王月兵
Owner CHINA JILIANG UNIV
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