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Preparing process of compound red skin blood-enriching oral liquid

A preparation process and technology for oral liquid, which is applied in the field of preparation of Fufang Hongyi Buxue Oral Liquid, can solve the problems of increasing raw material cost, loss of active ingredients of polysaccharides, etc., achieves the effects of simple and feasible preparation method, shortening extraction time, and avoiding waste of raw materials

Inactive Publication Date: 2018-06-22
XIANGYU PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The applicant's previous patented technologies 2008101590994 and 2015101684898 both involved the improvement of Compound Hongyi Oral Liquid. Among them, the patented technology 2008101590994 involved the improvement of the extraction process. Through the improvement of the extraction process of different raw materials, the efficacy of the drug was improved, but among them, peanut red Clothes can obtain higher amounts of proanthocyanidins, resveratrol, etc. through the above process, but it is not easy to use the above process for medlar and jujube, which will cause the loss of active ingredients of polysaccharides; patented technology 2015101684898 is based on the existing formula, adding The cost of a variety of Chinese herbal medicines has been reduced, but this method has greatly increased the cost of raw materials

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] The preparation technology of compound red clothing blood-enhancing oral liquid, it comprises the steps:

[0019] 1) Take 20g of fungus, add 16 times the weight of water, soak for 30 minutes, heat to a slight boil for 2 hours, filter, add 10 times the weight of water to the dregs, heat and boil for 1 hour, filter, combine the filtrates, and concentrate to The density is 1.02g / ml, and the fungus extract is obtained;

[0020] 2) Take 100g of Lycium barbarum, crush it, add 5 times the weight of water, and cut it with a high-speed shearer for 60 minutes to obtain the soaking liquid. % ethanol, and the control pressure is 0.8Mpa, the temperature is 60°C, 300rpm is stirred and extracted for 120min, the filtrate is collected by filtration, then the filtrate is evaporated under reduced pressure to remove ethanol, the residual liquid is collected, dried for 6h, and the drying temperature is 70°C to obtain the wolfberry fruit extract 1.79g of the substance; adopting the content ...

Embodiment 2

[0029] Effect of extraction process on effective substances of polysaccharides:

[0030] Taking Comparative Example 1 as an example, the process of Lycium barbarum and Jujube were respectively used in Comparative Example 1, and the content of polysaccharide was determined by the phenol-sulfuric acid method, and the influence of different processes on the yield of polysaccharide was detected; see Table 1 for details:

[0031] Table 1

[0032] group

Embodiment 3

[0034] Toxicity test:

[0035] In this experiment, healthy SD rats were used, and the dosage gradient of compound Hongyi Buxue Oral Liquid prepared in Example 1 was administered orally. The dose gradients were 1ml / kg and 5ml / kg, and the administration was continued for 45 days. Within one week afterward, there was no significant effect on animal growth status, active diet, hematology, blood biochemistry, organ tissue structure, and urine routine, which indicated that the clinical medication was safe and reliable.

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Abstract

The invention belongs to the technical field of medicine extraction, and discloses a preparing process of compound red skin blood-enriching oral liquid. The method includes the following steps of firstly, preparing an agaric extraction solution; secondly, preparing fructus lycii extracts; thirdly, preparing Chinese date extracts; fourthly, preparing a peanut skin extraction solution; fifthly, conducting boiling, filtering, subpackaging and sterilizing. The preparing method is simple and feasible, different traditional Chinese medicine components can be processed through different technologies,effective components of all raw materials are improved, the medicine effect is improved, and raw material waste is reduced.

Description

technical field [0001] The invention belongs to the technical field of medicine extraction, and in particular relates to a preparation process of compound Hongyi Buxue oral liquid. Background technique [0002] Anemia refers to a common clinical symptom in which the volume of red blood cells in the peripheral blood of the human body is low, which is lower than the lower limit of the normal range. Because the determination of red blood cell volume is complicated, it is often replaced by hemoglobin (Hb) concentration in clinical practice. The main causes of anemia are: (1) iron deficiency; (2) decreased EPO production; (3) metabolic poisons inhibit the proliferation of red blood cells; (4) inflammatory factors accelerate the removal of antibodies or immune complexes in the circulation (5) The increased generation of reactive oxygen species in CKD patients makes red blood cells prone to hemolysis. Clinical manifestations: (1) Nervous system: dizziness, tinnitus, headache, ins...

Claims

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Application Information

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IPC IPC(8): A61K36/815A61K9/08A61P7/06
CPCA61K9/0095A61K36/07A61K36/48A61K36/725A61K36/815A61K47/46A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 林凡友孙永喜张海雷杜玲杰王文天
Owner XIANGYU PHARMA
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