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Preparation process for starch self-reinforced composite material applied to hard capsule products

A reinforced composite material and hard capsule technology, which is applied in the field of medicine, can solve the problems of starch gel performance not meeting the capsule production process, starch moisture absorption and poor resistance to high-humidity environment, etc., to achieve excellent resistance to high-humidity environment performance, The effect of preventing starch gelatinization and preventing protein aggregation

Active Publication Date: 2018-06-26
HUNAN ER KANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Since the gelling performance of starch itself cannot meet the capsule production process, in order to overcome this deficiency, it is generally necessary to add a corresponding gelling agent in the current starch-based capsule preparation process to improve the processing performance
Although there have been a lot of research and literature on improving the quality and processing performance of starch capsules this year, the effect of starch on moisture absorption and resistance to high humidity environments is not good.

Method used

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  • Preparation process for starch self-reinforced composite material applied to hard capsule products

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Get the cassava starch 100Kg that the degree of esterification is 0.04, the tapioca starch 2g that amylopectin content is 87%, mix homogeneously.

[0026] Add purified water 0.5 times the mass of the mixture, add medicinal hydrochloric acid dropwise to the container to adjust the pH to 1, and circulate and stir in the container at a speed of 60-80r / min overnight, filter or centrifuge to obtain a solid mixture.

[0027] Add 0.1% Tween 80, 0.01% medicinal sodium hydroxide and 2 times water to the solid mixture.

[0028] Raise the temperature of the mixed material to 80-95° C., heat and stir for 1 hour to obtain a transparent glue solution.

[0029] The glue is degassed in vacuum, cooled to 50-65°C, kept warm for 2-3 hours, dried with hot air at 40-50°C for 24 hours, and crushed through a 100-mesh sieve.

Embodiment 2

[0031] Get the cassava starch 100Kg that degree of esterification is 0.04, the tapioca starch 8g that amylopectin content is 87%, mix homogeneously.

[0032] Add purified water twice the mass of the mixture, add organic acid dropwise to the container to adjust the pH to 2, and circulate and stir in the container at a speed of 60-80r / min overnight, filter or centrifuge to obtain a solid mixture.

[0033] Add 0.05% polyethylene glycol, 0.01% medicinal sodium bicarbonate and 3 times water to the solid mixture.

[0034] Raise the temperature of the mixed material to 80-95° C., heat and stir for 1 hour to obtain a transparent glue solution.

[0035] The glue is degassed in vacuum, cooled to 50-65°C, kept warm for 2-3 hours, dried with hot air at 40-50°C for 24 hours, and crushed through a 100-mesh sieve.

Embodiment 3

[0037] Get the rice starch 100Kg that the degree of esterification is 0.04, the large starch 10g that amylopectin content is 91.9%, mix homogeneously.

[0038] Add purified water twice the mass of the mixture, add organic acid dropwise to the container to adjust the pH to 3, and circulate and stir in the container at a speed of 60-80r / min overnight, filter or centrifuge to obtain a solid mixture.

[0039] Add 0.1% sodium carboxymethylcellulose, 0.02% sodium bicarbonate and 3 times water to the solid mixture.

[0040] Raise the temperature of the mixed material to 80-95° C., heat and stir for 1 hour to obtain a transparent glue solution.

[0041] The glue is degassed in vacuum, cooled to 50-65°C, kept warm for 2-3 hours, dried with hot air at 40-50°C for 24 hours, and crushed through a 100-mesh sieve.

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Abstract

The invention discloses a preparation process for a starch self-reinforced composite material applied to hard capsule products. The composite material uses one or a mixture of more than one selected from a group consisting of oxidized starch, cationic starch and esterified starch as a matrix phase and cooperatively utilizes glutinous or low-straight-chain-content raw starch from a same source; andthe finished composite material is a starch granule, film or starch sheet prepared through acid hydrolysis, grafting and gelatinization, and the starch granule, film or starch sheet can replace gelatin products as a raw material for preparing capsules. The composite material is prepared from easily available raw materials, and is obviously improved in barrier properties, processability, mechanical properties, etc. compared with individual components; and compared with conventional starch capsule technology, the composite material prepared by using the preparation process in the invention is obviously improved in resistance to high humidity environments.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a self-reinforcing composite material for hard capsule products. Background technique [0002] Capsule is the traditional most widely used packaging material in the pharmaceutical and functional food industries. The main raw material for the production of capsules is gelatin, which is a biological macromolecule with a ternary helical structure obtained by hydrolysis of animal skin and bone. This special structure makes it have some shortcomings and deficiencies in application, such as easy cross-linking with drugs containing aldehydes, reducing sugar-syl compounds and vitamin C, making it prone to a series of safety hazards; in recent years, mad cow disease, bird flu The rapid spread of diseases and other diseases around the world has also seriously restricted the safety of gelatin use. The US Food and Drug Administration believes that gelatin should be removed from the list o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K47/36
CPCA61K47/36A61K9/4816
Inventor 帅放文王向峰章家伟
Owner HUNAN ER KANG PHARMA
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