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Hard capsule prepared through electrostatic spinning and preparation method of hard capsule

A technology of electrospinning and hard capsules, which is used in capsule delivery, pharmaceutical formulations, filament/line forming, etc. It can solve the problems of extreme changes in capsule temperature and water content, unstable thickness, and prone to wrinkling and white spots. problems, to achieve the effect of extended application range and application potential, high porosity and specific surface area, easy adjustment and control

Inactive Publication Date: 2018-06-29
HUNAN ER KANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the thickness of hard capsules produced by this method is affected by various factors such as the viscosity of the glue, temperature, and dipping speed, so it is difficult to control and the thickness is unstable; The temperature and water content of the capsules vary greatly, and if the process is slightly improperly controlled, it is easy to appear wrinkled skin, white spots, and even cracks

Method used

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  • Hard capsule prepared through electrostatic spinning and preparation method of hard capsule
  • Hard capsule prepared through electrostatic spinning and preparation method of hard capsule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1-2 is the production embodiment of gelatin capsule embryo, and embodiment 3-4 is the production embodiment of starch capsule embryo, wherein embodiment 1, embodiment 3 are irregular network nanofiber capsule embryo, embodiment 2, embodiment 4 is the nanofiber capsule embryo arranged in parallel.

[0029] Example 1

[0030] 1) Pour the prepared gelatin glue into the storage tank, adjust the temperature control device to maintain the temperature at 65°C, adjust the voltage setting value of the high-voltage power supply device to 1000V, adjust the rotation speed of the nozzle to 30rad / s, and spin The time is set at 1.5min, corn oil is used for the oil brush, the temperature of the drying hair dryer is set at 25±5°C, and the humidity is set at 45%.

[0031] 2) Select the mold with the corresponding shape and type, install it on the main transmission device, the mold is directly grounded through the metal interface on the transmission track, and the embryo body ...

Embodiment 2

[0036] 1) Pour the prepared gelatin glue into the storage tank, adjust the temperature control device to maintain the temperature at 65°C, adjust the voltage setting value of the high-voltage power supply device to 1000V, adjust the rotation speed of the nozzle to 200rad / s, and spin The time is set to 40s, the oil brush uses corn oil, the temperature of the drying hair dryer is set at 25±5°C, and the humidity is set at 45%.

[0037] 2) Select the mold with the corresponding shape and type, install it on the main transmission device, the mold is directly grounded through the metal interface on the transmission track, and the embryo body outlet is placed to contain the goods;

[0038] 3) Start the operation switch of the equipment, start production, and add the gelatin glue in the storage tank in time;

[0039] 4) Close the equipment after production, and clean and maintain the equipment.

[0040] The gelatin capsule sample 2 with parallel arrayed nanofibers was obtained.

Embodiment 3

[0042] 1) Pour the prepared starch glue into the storage tank, adjust the temperature control device to maintain the temperature at 70°C, adjust the voltage setting value of the high-voltage power supply device to 1300V, adjust the rotation speed of the nozzle to 80rad / s, and spin The time is set at 2 minutes, corn oil is used for the oil brush, the temperature of the drying hair dryer is set at 25±5°C, and the humidity is set at 55%.

[0043] 2) Select the mold with the corresponding shape and type, and install it on the main transmission device. The mold is connected to a certain negative voltage through the metal interface on the transmission track, and the embryo body outlet is placed to store the goods;

[0044] 3) Start the operation switch of the equipment, start production, and add the starch glue in the storage tank in time;

[0045] 4) Close the equipment after production, and clean and maintain the equipment.

[0046] Obtain irregular network nanofiber starch capsu...

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Abstract

The invention relates to a hard capsule prepared through electrostatic spinning and a preparation method of the hard capsule. The capsule is woven from nanoscale collagen fibers in an electrostatic spinning manner and has higher intensity and tenacity than the common wrapping and dipping capsule under the same thickness; in addition, the specific surface area of a material is greatly increased; the capsule has higher guest molecule inclusion capacity and faster digestion property; moreover, due to the specificity of a preparation technology, the multilayer and multistage capsule made from a composite can be prepared very conveniently; the wall thickness of the capsule is simple and easy to control; defective products hardly appear in a preparation process; the product quality is stabler and more controllable; the capsule is prepared by using a specific electrostatic spinning capsule blank-making machine and the matched preparation technology; a production process is fully automatic, safe and efficient; modules of equipment can be replaced according to different production requirements.

Description

technical field [0001] The invention relates to a novel capsule and a manufacturing method thereof. The novel capsule is prepared by electrospinning, has a nanoscale fiber structure, and belongs to the fields of pharmaceutical manufacturing and food processing. Background technique [0002] Capsule is a capsule shell used to fill drugs that are not suitable for direct oral administration. It is generally divided into hard capsules and soft capsules. Among them, hard capsules are also called hollow capsules, and are generally composed of two parts, a cap and a body. Capsules are widely used in the field of medicine. Various drugs that are irritating to the mouth and esophagus or have a bad taste have capsule dosage forms. In addition to improving the experience of taking medicine, they can also effectively improve the stability of the drug, avoid light and moisture, and prolong the life of the drug. The shelf life of the preparation. [0003] At present, the vast majority of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K47/42A61J3/07D01D5/00
CPCA61J3/077A61K9/4825A61K9/4833D01D5/0061
Inventor 帅放文王向峰章家伟
Owner HUNAN ER KANG PHARMA
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