Liquid crystal gel microcapsules and preparation method thereof

Abstract

The invention discloses liquid crystal gel microcapsules and a preparation method thereof. The liquid crystal gel microcapsules are prepared from alginate, glyceryl dioleate and phosphatidylcholine, wherein glyceryl dioleate and phosphatidylcholine form liquid crystal nanoparticles in water; the microencapsulation preparation method of the liquid crystal nanoparticles comprises the steps of firstly, dissolving and dispersing medicines, phosphatidylcholine and glyceryl dioleate into a liquid crystal precursor solution in presence of a cosolvent, and adopting a high pressure homogenization method to obtain the medicine-loaded liquid crystal nanoparticles; then, evenly mixing the medicine-loaded liquid crystal nanoparticles with a sodium alginate solution, and dropwise adding a cross-linkingagent for carrying out a cross-linking reaction; then, freeze-drying to obtain the spherical alginate gel microcapsules. The method is simple and easy to implement, and is suitable for industrializedproduction; the capsule wall material adopted by the microcapsules is wide in source and low in price, thus being suitable for popularization of products; furthermore, the liquid crystal gel microcapsules has an obvious slow-release effect compared with the liquid crystal nanoparticles, and significantly improves the stability of the liquid crystal nanoparticles, so that the problem that the liquid crystal nanoparticles are difficult to store is solved to a certain extent.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a liquid crystal gel microcapsule and a preparation method thereof. Background technique [0002] Most pharmaceutically active compounds face the problem of low solubility. Research shows that 40% of marketed drugs and 70% of drugs under research are poorly soluble drugs. The slow dissolution rate and low dissolution degree of poorly soluble drugs lead to low bioavailability of drugs and fail to achieve ideal clinical efficacy. The drug must be delivered to the treatment site at a certain speed and reach a therapeutic concentration in order to exert its curative effect in time. This process requires the use of pharmaceutical preparations to increase the dissolution rate and solubility of the drug, thereby increasing the bioavailability of the drug and improving the clinical efficacy. The rate and route of drug dissolution and release from formulations are mainly reg...

AI Technical Summary

Problems solved by technology

The industrialization and commercialization of liquid crystal nanoparticle preparations are mainly limited by two bottlenecks: one is the lack of efficient and feasible industrial preparation methods, and the other is the stability of the liquid crystal nanoparticle dispersion system

The huge specific surface area of ​​liquid crystal nanoparticles makes this dispersion system extremely unstable, prone to precipitation and aggregation, and the preparation method cannot realize the industrial production of nanoparticle dispersion system, but only stops at the laboratory basic research; drug leakage inactivation and nanoparticle The problem of aggregation and precipitation also exists in the storage process of liquid crystal nanoparticles, and is even more serious; the nanoparticles prepared by the existing method need a higher content of stabilizer and a large volume of dispersant to disperse the nanoparticles, resulting in the dispersion of nanoparticles in the nanoparticle dispersion system. And the content of the drug is lower, the actual yield is lower

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