Traditional Chinese medicine composition treating coronary heart disease and angina pectoris and preparation thereof

A technology for coronary heart disease angina pectoris and a composition is applied in the field of medicine to achieve the effects of enhancing myocardial contractility, increasing blood flow, promoting collateral circulation and blood flow redistribution

Inactive Publication Date: 2018-07-24
广西中医药大学第一附属医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The applicant, on the basis of "Yangxin Tongmai Prescription", which is the experience prescription of Professor Li Xiguang in the treatment of coronary heart disease and angina pectoris, has added Fufangteng, Yejiaoteng and Millipede vine, which have good curative effects in the treatment of coronary heart disease and angina pectoris. The original formula is more suitable for the characteristics of coronary heart disease and angina pectoris in Guangxi, and the curative effect is more significant. At present, there is no report of the same formula as our formula in similar reports in China

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] Example 1 tablet

[0063] Weigh 50kg of Fufangteng, 50kg of Nightingale, 50kg of Caulis Spatholobus, 150kg of Codonopsis, 150kg of Astragalus, 50kg of Ophiopogon japonicus, 60kg of Schisandra, 60kg of Radix Paeoniae Alba, 70kg of Salvia miltiorrhiza, 40kg of sandalwood, 50kg of woody fragrance, 75kg of cassia twig, licorice 45kg; take all the medicinal materials, mix them and add water to extract twice, the amount of water added each time is equivalent to 12 times and 10 times the total weight of the medicinal materials, the two extraction times are 3 hours and 2 hours respectively, combine the extracts, filter, and concentrate the filtrate A clear paste with a relative density of 1.10 at 70°C was added to tablet excipients dextrin, talcum powder, sodium carboxymethyl starch, and cellulose derivatives, and tablets were prepared according to a conventional scheme.

Embodiment 2

[0064] Example 2 tablet

[0065] Weigh 60kg of fufangteng, 60kg of nightjiaoteng, 60kg of Caulis Spatholobus, 160kg of codonopsis, 160kg of astragalus, 57kg of Ophiopogon japonicus, 68kg of schisandra, 65kg of white peony root, 75kg of salvia miltiorrhiza, 46kg of sandalwood, 55kg of woody fragrance, 82kg of cassia twig, Glycyrrhiza 50kg; take all the medicinal materials, mix them and use 40% ethanol to reflux extract 3 times, each time the amount of ethanol is 10 times, 8 times, 6 times of the total amount of medicinal materials, and the three extraction times are respectively 4 hours, 2 hours, 1 hour, Combine the extracts, filter, concentrate the filtrate to a clear paste with a relative density of 1.05 at 70°C, add tablet excipients powdered sugar, starch, polyethylene glycol, talcum powder, and cellulose derivatives, and make tablets according to the conventional scheme.

Embodiment 3

[0066] Embodiment 3 capsules

[0067] Weigh 70kg of Fufangteng, 70kg of Noctua japonica, 70kg of Caulis Spatholobus, 170kg of Codonopsis, 168kg of Astragalus, 62kg of Ophiopogon japonicus, 72kg of Schisandra chinensis, 72kg of Radix Paeoniae Alba, 83kg of Salvia miltiorrhiza, 52kg of sandalwood, 60kg of woody fragrance, 90kg of cassia twig, Glycyrrhiza 55kg; take all the medicinal materials, add water to extract twice after mixing, the amount of water added each time is equivalent to 12 times and 8 times of the total weight of medicinal materials, each extraction time is 3 hours and 2 hours respectively, combine the extracts, filter, and concentrate the filtrate When the relative density is 1.10 at 70 DEG C, add ethanol to make the alcohol content 40%, let it stand for 12 hours, filter, and when the filtrate is concentrated to 70 DEG C, the relative density is 1.05 extract, add capsule auxiliary materials starch, Ethanol, magnesium stearate, make capsules according to conventi...

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PUM

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Abstract

The invention discloses a traditional Chinese medicine composition treating coronary heart disease and angina pectoris. The traditional Chinese medicine composition is prepared from folium euonymi fortunei, stem of tuber fleeceflower, caulis spatholobi, radix codonopsis, radix astragali, radix ophiopogonis, fructus schisandrae chinensis, radix paeoniae alba, radix salviae miltiorrhizae, lignum Santali albi, radix aucklandiae, ramulus cinnamomi, and radix glycyrrhizae preparata. The traditional Chinese medicine composition is prepared from multiple Chinese herbs, is safe and mild, has very small side effects to human bodies, has functions of supplementing blood and nourishing heart, tonifying qi and promoting blood circulation, tonifying spleen and regulating the function of the stomach, activating pulse, removing obstruction in channels to relieve pain, tonifying qi and strengthening the superficial, and effectively treats coronary heart disease and angina pectoris. The traditional Chinese medicine composition can be prepared into capsules, granules, oral solution and so on, thereby being convenient to take and carry by different patients and being applicable to different crowds. Further, the traditional Chinese medicine composition has a scientific and reasonable formula, has small side effects, is easy to prepare, is low in preparation cost, can relive the pain of patients remarkably and lower the financial burden of patients, thereby having high promotion value.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a traditional Chinese medicine composition for treating coronary heart disease angina pectoris and its preparation. Background technique [0002] Coronary heart disease is the most common heart disease, which refers to myocardial dysfunction and / or organic disease caused by coronary artery stenosis and insufficient blood supply, so it is also called ischemic cardiomyopathy. The World Health Organization classifies coronary heart disease as follows: (1) primary cardiac arrest; (2) angina pectoris; (3) myocardial infarction; (4) heart failure in ischemic heart disease; (5) arrhythmia. Coronary heart disease is a major, non-sensing disease that endangers human health. According to WHO statistics, coronary heart disease is the most common cause of death in the world, known as the "first killer". In 2014, about 25 million people died of cardiovascular disease in the world, accounting for 1 / 4 ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8968A61P9/10
CPCA61K36/185A61K36/285A61K36/344A61K36/37A61K36/481A61K36/484A61K36/486A61K36/537A61K36/54A61K36/57A61K36/65A61K36/704A61K36/71A61K36/79A61K36/8968A61K2236/331A61K2236/333A61K2236/39A61K2236/53A61K2300/00
Inventor 王庆高卢健棋凌芸
Owner 广西中医药大学第一附属医院
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