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Polyether ether ketone bone defect repair material and preparation method

A technology of polyetheretherketone and repair materials, applied in prosthesis, coating, tissue regeneration, etc., can solve the problems of low biological activity, poor osseointegration ability, no antibacterial effect, etc., and achieve the effect of simple process and low cost

Active Publication Date: 2020-01-31
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to overcome the defects of low bioactivity, no antibacterial effect and poor osseointegration ability with bone tissue in the existing polyetheretherketone bone defect repair materials, and provide people with a kind of polyetheretherketone with good antibacterial properties and Polyether ether ketone bone defect repair material with good osteogenic activity and preparation method

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] The polyether ether ketone bone defect repair material in this example is characterized in that the surface of the polyether ether ketone bone defect repair material has a micro-pore-nano-pore multi-level hole structure (surface micro-nano topological structure), and is also loaded with Simvar Statin (Simvastatin), polylactic acid porous micromembrane and tobramycin microspheres.

[0017] The preparation method of the polyether ether ketone bone defect repair material in this example is as follows:

[0018] Mix concentrated sulfuric acid and concentrated nitric acid at a ratio of 1:1 to obtain a mixed acid treatment solution. Put the polyether ether ketone base material into the mixed acid treatment solution and react with ultrasound for 13 minutes. Take out the polyether ether ketone base material and put it into the deionized Ultrasound in water for more than 3 hours to remove the surface residues of polyetheretherketone to obtain a polyetheretherketone bone defect re...

Embodiment 2

[0025] The preparation method of the polyether ether ketone bone defect repair material in this example is: mix concentrated sulfuric acid and concentrated nitric acid in a ratio of 2:1 to obtain a mixed acid treatment solution, put the polyether ether ketone base material into the mixed acid treatment solution, and ultrasonically react After 15 minutes, take out the polyetheretherketone substrate, put it into deionized water, and ultrasonicate for more than 3 hours to remove the residues on the surface of polyetheretherketone, and obtain a micropore-nanopore hierarchical structure on the surface (surface micro-nano topological structure ) polyether ether ketone bone defect repair material;

[0026] The polyether ether ketone bone defect repair material with micropore-nanopore hierarchical structure (surface micro-nano topological structure) on the surface was soaked in simvastatin dimethyl sulfoxide aqueous solution for 5 days, wherein the concentration of simvastatin was 0.5 ...

Embodiment 3

[0029] The preparation method of the polyether ether ketone bone defect repair material in this example is: mix concentrated sulfuric acid and concentrated nitric acid in a ratio of 3:1 to obtain a mixed acid treatment solution, put the polyether ether ketone base material into the mixed acid treatment solution, and ultrasonically react After 5 minutes, take out the polyetheretherketone substrate, put it into deionized water, and ultrasonicate for more than 3 hours to remove the residues on the surface of polyetheretherketone, and obtain a micropore-nanopore hierarchical hole structure on the surface (surface micro-nano topological structure ) polyether ether ketone bone defect repair material;

[0030] The polyether ether ketone bone defect repair material with micropore-nanopore hierarchical structure (surface micro-nano topological structure) on the surface was soaked in simvastatin dimethyl sulfoxide aqueous solution for 4 days, wherein the concentration of simvastatin was ...

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PUM

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Abstract

The invention belongs to a polyetheretherketone bone defect repair material and a preparation method thereof in the field of medical materials. The surface of the polyetheretherketone bone defect repair material has a micropore-nanopore multilevel hole structure, and is also loaded with simvastatin, Polylactic acid porous micromembranes and tobramycin microspheres. The present invention overcomes the defects of low bioactivity, no antibacterial effect and poor osseointegration ability with bone tissue in the existing polyether ether ketone bone defect repair materials, and the provided polyether ether ketone bone defect repair materials have good antibacterial properties performance and good osteogenic activity, and the preparation method of the polyetheretherketone bone defect repair material provided has simple process and low cost.

Description

technical field [0001] The invention belongs to the field of medical materials, and in particular relates to a polyether ether ketone bone defect repair material and a preparation method. Background technique [0002] Bone defects caused by congenital deformities and injuries are still a difficult problem in basic research and clinical treatment in the fields of orthopedics, oral and maxillofacial surgery, and neurosurgery. The special engineering plastic polyetheretherketone (PEEK) has become the most promising hard tissue repair material that can replace traditional metal medical materials due to its excellent mechanical properties, chemical stability and biocompatibility. But the fatal point is that PEEK is a biologically inert material, and its osseointegration with bone tissue is poor, which limits its application in the field of hard tissue repair to a certain extent. On the other hand, the surface of the implant material is likely to cause bacterial adhesion and biof...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/18A61L27/54A61L27/56A61L27/50A61L27/36A61L27/28
CPCA61L27/18A61L27/28A61L27/36A61L27/50A61L27/54A61L27/56A61L2300/406A61L2300/412A61L2430/02C08L61/16C08L67/04
Inventor 邓怡邓李俊谢克难
Owner SICHUAN UNIV
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