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Water-soluble sarafloxacin hydrochloride soluble powder for veterinary use and preparation method thereof

A sarafloxacin hydrochloride soluble technology is applied in the field of water-soluble veterinary sarafloxacin hydrochloride soluble powder and its preparation. The preparation method is simple and easy, the dissolution speed is fast, and the cost is low

Inactive Publication Date: 2018-07-27
厦门汇承科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, sarafloxacin hydrochloride has poor water solubility, which greatly limits its application. In clinical application, it is necessary to find a preparation that is easy to dissolve at a high concentration to greatly improve the clinical use of this product.
[0004] However, sarafloxacin hydrochloride is slightly soluble in water, the absorption efficiency of livestock and poultry is low after taking it, and the drug effect is released slowly

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] A water-soluble veterinary sarafloxacin hydrochloride soluble powder, comprising the following raw materials: 30 g of sarafloxacin hydrochloride, 5 g of poloxamer 188, 10 g of malonic acid, 5 g of soluble starch, 1 g of polycarboxylic acid, 10 g of anhydrous glucose, Distilled water 300g.

[0018] A method for preparing water-soluble veterinary sarafloxacin hydrochloride soluble powder, comprising the following steps: (1) putting sarafloxacin hydrochloride into an ultrafine pulverizer to pulverize for 20 minutes to obtain sarafloxacin hydrochloride powder for later use; 2) Put anhydrous glucose into an ultrafine pulverizer for 10 minutes to obtain anhydrous glucose powder for later use; (3) Pour poloxamer 188 and malonic acid into distilled water, heat and stir for 10 minutes to obtain a mixed solution , the heating temperature is 50°C; (4) Add soluble starch and polycarboxylic acid into the mixture, stir and mix, the stirring speed is 180r / min, the mixing temperature i...

Embodiment 2

[0020] A water-soluble veterinary sarafloxacin hydrochloride soluble powder, comprising the following raw materials: 50 g of sarafloxacin hydrochloride, 10 g of poloxamer 188, 20 g of malonic acid, 15 g of soluble starch, 6 g of polycarboxylic acid, 20 g of anhydrous glucose, Distilled water 500g.

[0021] A method for preparing water-soluble veterinary sarafloxacin hydrochloride soluble powder, comprising the following steps: (1) putting sarafloxacin hydrochloride into an ultrafine pulverizer and pulverizing for 30 minutes to obtain sarafloxacin hydrochloride powder for later use; 2) Put the anhydrous glucose into an ultrafine pulverizer for 20 minutes to obtain anhydrous glucose powder for later use; (3) Pour poloxamer 188 and malonic acid into distilled water, heat and stir for 20 minutes to obtain a mixed solution , heating temperature 60°C; (4) Add soluble starch and polycarboxylic acid into the mixture, stir and mix at a stirring speed of 180r / min, mixing temperature 65°...

Embodiment 3

[0023] A water-soluble veterinary sarafloxacin hydrochloride soluble powder, comprising the following raw materials: 45 g of sarafloxacin hydrochloride, 188 6 g of poloxamer, 15 g of malonic acid, 10 g of soluble starch, 4 g of polycarboxylic acid, 15 g of anhydrous glucose, 400g of distilled water.

[0024] A method for preparing water-soluble veterinary sarafloxacin hydrochloride soluble powder, comprising the following steps: (1) putting sarafloxacin hydrochloride into an ultrafine pulverizer and pulverizing for 30 minutes to obtain sarafloxacin hydrochloride powder for later use; 2) Put the anhydrous glucose into an ultrafine pulverizer for 20 minutes to obtain anhydrous glucose powder for later use; (3) Pour poloxamer 188 and malonic acid into distilled water, heat and stir for 20 minutes to obtain a mixed solution , the heating temperature is 55°C; (4) Add soluble starch and polycarboxylic acid into the mixture, stir and mix, the stirring speed is 180r / min, the mixing te...

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PUM

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Abstract

The invention discloses water-soluble sarafloxacin hydrochloride soluble powder for veterinary use and a preparation method thereof. The water-soluble sarafloxacin hydrochloride soluble powder is prepared from the following raw materials in parts by weight: 30 to 50 parts of sarafloxacin hydrochloride, 5 to 10 parts of poloxamer 188, 10 to 20 parts of malonic acid, 5 to 15 parts of soluble starch,1 to 6 parts of polycarboxylic acid, 10 to 20 parts of anhydrous glucose and 300 to 500 parts of distilled water. The water-soluble sarafloxacin hydrochloride soluble powder disclosed by the invention has the advantages of high stability in water, good water solubility and high dissolution rate, has a rapid dissolution speed and is convenient for livestock and poultry to orally take; the livestock and poultry can easily absorb medicines; the preparation method disclosed by the invention is simple and feasible and low in cost, has no pollution, and is simple in procedures and easy to realize.

Description

technical field [0001] The invention relates to the field of medicines, in particular to a water-soluble veterinary sarafloxacin hydrochloride soluble powder and a preparation method thereof. Background technique [0002] As far as the inventor knows, sarafloxacin is the first third-generation quinolone drug approved by the United States for food animals. It is another veterinary-specific quinolone approved by the FDA after enrofloxacin and danofloxacin drugs. [0003] Sarafloxacin hydrochloride has a wide antibacterial spectrum and strong antibacterial activity. It has a good killing effect on Gram-positive bacteria, negative bacteria, anaerobic bacteria, mycoplasma, and chlamydia. It can be used to prevent and treat various bacterial diseases, such as swine , Escherichia coli disease, salmonellosis, mycoplasma disease and staphylococcal infection of chickens, and can also be used for infectious diseases of aquatic animals and silkworm sensitive bacteria. However, saraflo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K31/496A61P31/04
CPCA61K9/146A61K31/496A61P31/04
Inventor 刘凯卫
Owner 厦门汇承科技有限公司