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Collagen sustained release hydrogel containing fibroblast growth factor 10

A technology of fibroblasts and growth factors, which is applied in the direction of medical preparations containing active ingredients, medical preparations with inactive ingredients, and non-effective ingredients in polymer compounds, which can solve the problem of low gelation temperature and lower poloxamer usage etc.

Active Publication Date: 2018-07-31
浙江唯美生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when poloxamer is used as the matrix to prepare temperature-sensitive materials, high-concentration poloxamer often has certain cytotoxicity, so the temperature-sensitive gel that can be industrialized needs to reduce the amount of poloxamer used, and has a low gelling temperature

Method used

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  • Collagen sustained release hydrogel containing fibroblast growth factor 10
  • Collagen sustained release hydrogel containing fibroblast growth factor 10
  • Collagen sustained release hydrogel containing fibroblast growth factor 10

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0011] 1. Experimental Instruments and Materials

[0012] 1.1 Experimental Instruments

[0013] pH meter: Shanghai Precision Scientific Instrument Co., Ltd. SNB-4 acidity meter

[0014] CO 2 Incubator: Shanghai Xinmiao Medical Device Manufacturing Co., Ltd. BB15

[0015] Electronic analytical balance: Shanghai Fangrui Instrument Co., Ltd. FA2204

[0016] Multifunctional microplate reader: American MD SpectraMax M3

[0017] Osmometer: American Advanced Fiske 110

[0018] Electric constant temperature incubator: Shanghai Senxin Experimental Instrument Co., Ltd. DRP-9052

[0019] Electrophoresis instrument, gel imager: Bio-Rad

[0020] HPLC: Agilent 1200

[0021] Vertical pressure steam sterilizer: Shanghai Boxun Industrial Co., Ltd. Medical Equipment Factory YXQ-LS-70A

[0022] Gel strength tester: British Sheen Ref414

[0023] 1.2 Experimental reagents

[0024] FGF10 and its standard products: Zhejiang Key Laboratory of Biotechnology and Pharmaceutical Engineering

...

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Abstract

The present invention provides a collagen sustained release hydrogel containing human fibroblast growth factor 10, the collagen sustained release hydrogel comprises the human fibroblast growth factor10 (FGF10P) and excipients, wherein the excipients include collagen, poloxamer 407, glycerol and trehalose.

Description

technical field [0001] The invention belongs to the technical field of protein or polypeptide medicine, in particular, the invention relates to a sustained-release hydrogel preparation of fibroblast growth factor 10. technical background [0002] Fibroblast growth factor (fibroblast growth factor, FGF10) is the 10th member of the FGF family. It has the functions of nourishing and protecting neurons, promoting injury repair, and inducing angiogenesis in ischemic areas. It can significantly accelerate acute injury healing. However, when FGF10 is applied to the repair of chronic inflammatory wounds, the effect is not satisfactory (Sandborn WJ1, Sands BE, Wolf DC et al. Repifermin (keratinocyte growth factor-2) for the treatment of active ulcerative colitis: a randomized, double-blind , placebo-controlled, dose-escalation trial. [J] Aliment Pharmacol Ther.2003,17(11):1355-64). The main reason is that there is an intracellular environment regulated by inflammatory factors in chr...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K38/18A61K47/42A61K47/10A61K47/36A61P17/02
CPCA61K9/06A61K38/1825A61K47/10A61K47/36A61K47/42
Inventor 王晓杰
Owner 浙江唯美生物科技有限公司
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