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Dairy cow uterus flushing fluid formula and preparation method thereof

A technology for flushing fluid and uterus, which is applied in pharmaceutical formulations, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc. Irritant and carcinogenic, easy to degrade, and the effect of preventing metritis

Inactive Publication Date: 2018-08-10
VETERINARY INST XINJINAG ACADEMY OF ANIMAL SCI CLINIC MEDICAL SCI RES CENT XINJIANG ACADEMY OF ANIMAL HUSBANDRY SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, antibiotics are easy to cause residues, resulting in the emergence of drug-resistant strains and endangering food safety. Disinfectants are generally not easy to degrade or irritating

Method used

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  • Dairy cow uterus flushing fluid formula and preparation method thereof
  • Dairy cow uterus flushing fluid formula and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Embodiment 1, a dairy cow uterine washing liquid, by weight, comprising 0.5 parts of sodium citrate, 1 part of trehalose, 0.15 parts of polyvinylpyrrolidone, 0.2 parts of polyethylene glycol, 1.5 parts of percarbamide, and 90 parts of water .

[0021] Preparation method: Take 0.5 parts of sodium citrate, 1 part of trehalose, 0.15 parts of polyvinylpyrrolidone (molecular weight 30 kilodaltons), 0.2 parts of polyethylene glycol (molecular weight 4 kilodaltons) and add 90 parts of water, stir for 5 -20 minutes, after fully dissolving, adjust the pH to 7.2-7.4 with inorganic acid and alkali, then add 1.5 parts of percarbamide and stir for 3-5 minutes, fully dissolve, and the product is ready.

[0022] Method of use: take 30-300 mL of the milk cow uterine washing solution prepared in this embodiment to wash the uterus.

Embodiment 2

[0023] Embodiment 2, a dairy cow uterine washing liquid, comprising 0.5 parts of sodium citrate, 1 part of trehalose, 0.15 parts of polyvinylpyrrolidone, 0.2 parts of polyethylene glycol, 1.5 parts of hydrogen peroxide, and 90 parts of water in parts by weight .

[0024] Preparation method: Take 0.5 parts of sodium citrate, 1 part of trehalose, 0.15 parts of polyvinylpyrrolidone (molecular weight 30 kilodaltons), 0.2 parts of polyethylene glycol (molecular weight 4 kilodaltons) and add 90 parts of water, stir for 5 -20 minutes, after fully dissolving, adjust the pH to 7.2-7.4 with inorganic acid and alkali, then add 2.0 parts of hydrogen peroxide, and stir for 3-5 minutes to obtain the product.

[0025] Method of use: take 30-300 mL of the milk cow uterine washing solution prepared in this embodiment to wash the uterus.

Embodiment 3

[0026] Embodiment 3, a dairy cow uterine washing liquid, comprising 0.1 part of sodium citrate, 0.1 part of trehalose, 0.01 part of polyvinylpyrrolidone, 0.05 part of polyethylene glycol, 0.5 part of percarbamide, and 60 parts of water in parts by weight .

[0027] The preparation method is the same as in Example 1.

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Abstract

The invention relates to a diary cow uterus flushing liquid formula. The formula comprises, by weight, 0.1-10 parts of acid-base buffering agent, 0.5-15 parts of fungicide, 0.1-10 parts of trehalose,0.01-10 parts of polyvinylpyrrolidone, 0.05-5 parts of polyethylene glycol and 60-90 parts of water. A preparation method comprises the steps that the acid-base buffering agent, the trehalose, polyvinylpyrrolidone, polyethylene glycol and water are mixed according to the dosage of all the ingredients, stirring is conducted for 5-20 min slowly at a constant speed, the pH is adjudged to be 6.5-8.0,subsequently, the fungicide is added and stirred for 3-5 min, and the diary cow uterus flushing liquid is obtained. The dosage ratio of the diary cow uterus flushing liquid prepared through the methodto the water is (10-100):(0-90). The diary cow uterus flushing liquid does not contain antibiotics or materials high in irritation and is easy to degrade and capable of avoiding irritation and carcinogenicity to people and livestock; meanwhile the phenomenon that due to the broad spectrum and long-acting fungicide, the environmental microecology is continuously destroyed is avoided.

Description

technical field [0001] The invention belongs to the technical field of research and development of veterinary health care preparations, and in particular relates to a formula of dairy cow uterine flushing liquid without antibiotic residues, a preparation method and a use method thereof. Background technique [0002] The incidence of cow endometritis is about 20% - 50%, but 60% - 90% of cow infertility is caused by it. Microbial infection, imbalance of body hormone levels, and malnutrition are the main causes of endometritis, especially bacterial infection is a common cause of endometritis. Uterine flushing is the main method to prevent and treat endometritis in dairy cows. At present, it is mainly used to perfuse broad-spectrum antibacterial drugs and disinfectants, such as tetracycline, cephalosporin antibiotics and sulfa drugs, 0.1% potassium permanganate, 0.1% Revnu Diol, 0.05% chlorhexidine, 0.05% bromogeramine and other solutions, the flushing volume is generally 30--3...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/40A61K31/17A61K31/79A61K9/08A61K47/12A61K47/32A61K47/10A61K47/26A61P15/00A61P31/04A61P31/02
CPCA61K33/40A61K9/0034A61K9/08A61K31/17A61K31/79A61K47/10A61K47/12A61K47/26A61K47/32A61P15/00A61P31/02A61P31/04A61K2300/00
Inventor 王登峰吴建勇刘志强李建军古努尔·吐尔逊杨学云刘丽娅金映红刘艳丰王文奇班万里
Owner VETERINARY INST XINJINAG ACADEMY OF ANIMAL SCI CLINIC MEDICAL SCI RES CENT XINJIANG ACADEMY OF ANIMAL HUSBANDRY SCI
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