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Toothpaste with phosphosilicate glass

A technology of phosphosilicate glass and toothpaste, applied in the field of daily chemicals, can solve problems such as inability to promote tooth restoration, and achieve the effects of relieving dentin hypersensitivity, preventing dental caries, and inhibiting gingival bleeding

Inactive Publication Date: 2018-08-17
INST OF CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the current toothpaste has the problem that it cannot promote the self-repair of the tooth

Method used

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  • Toothpaste with phosphosilicate glass
  • Toothpaste with phosphosilicate glass
  • Toothpaste with phosphosilicate glass

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Calcium phosphosilicate glass can promote the formation of mineralized layer in artificial saliva for 1 day, as figure 1 As shown, compared with traditional 45S5 glass, it can better promote the differentiation of dental pulp cells into odontoblasts, such as figure 2 As shown, it can also promote the production of growth factors. Introducing it into toothpaste can repair tooth trauma, inhibit gum bleeding, and slow down periodontitis.

Embodiment 2

[0036] A toothpaste containing phosphosilicate glass, wherein the weight percentage of each component is: glycerin 40%, hydrated silicic acid 12%, sodium carboxymethylcellulose 6%, calcium phosphosilicate glass 40%, dodecane Sodium sulfate 1%, xylitol 0.5%, essence 0.5%.

[0037] The prepared toothpaste was brushed on the surface of the dentin layer (soaked in artificial saliva for 12 hours) for 5 minutes, then rinsed with artificial saliva and dried in the air. Through SEM observation, it can be seen that a large number of mineralized layers are formed on the surface of dentin, such as image 3 shown.

Embodiment 3

[0039] A toothpaste containing phosphosilicate glass, wherein the weight percentage of each component is: glycerin 50%, polyethylene glycol 10%, silicon dioxide 8%, carbomer 2%, strontium phosphosilicate glass 25% , sodium lauryl sulfate 1%, sodium saccharin 0.1%, essence 0.9%, deionized water 3%.

[0040] The prepared toothpaste was brushed on the surface of the dentin layer (soaked in artificial saliva for 12 hours) for 5 minutes, then rinsed with artificial saliva and dried in the air. Through SEM observation, it can be seen that there is a mineralized layer on the surface of the dentin, such as Figure 4 shown.

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Abstract

The invention belongs to the technical field of daily chemicals, and particularly relates to toothpaste with phosphosilicate glass. The toothpaste comprises the phosphosilicate glass, humectants, friction agents, binders, surfactants, sweeteners and essence. The toothpaste with the phosphosilicate glass has the advantages that the phosphosilicate glass is high in dissolution and has a stable pH (potential of hydrogen) value; the phosphosilicate glass has the quick mineralization ability in saliva in oral cavities, expression of diversified genes and formation of growth factors can be promotedby the phosphosilicate glass, accordingly, tooth wound can be repaired, dentin hypersensitivity can be relieved, and dental caries can be prevented; gingival bleeding can be inhibited, and periodontitis and the like can be relieved; oral ulcer can be prevented or treated; cementum absorption can be repaired, and effects of relieving tooth loosening and the like can be realized; tooth hypersensitivity can be prevented or treated.

Description

technical field [0001] The invention belongs to the technical field of daily chemicals, and in particular relates to a toothpaste containing phosphosilicate glass. Background technique [0002] With the improvement of people's living standards and the increasing emphasis on oral health care, the demand for toothpaste has developed from a general cleaning type to a curative type. [0003] Bioglass is a bioactive material that releases ions (such as Ca 2+ 、Na + ), forming SiO on the material surface 2 layer of silica gel, then Ca 2+ and PO 4 3- Deposit crystals on the silica gel layer to form hydroxyapatite, which can prevent and alleviate tooth allergy when used in toothpaste. However, since the repaired parts are all composed of minerals and have poor toughness, they will still fall off during the friction process of brushing teeth, so it is difficult to solve the problems of tooth sensitivity and tooth damage in essence. Patent document CN103006529B discloses that bi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/25A61K8/24A61P1/02A61Q11/00
CPCA61K8/24A61K8/25A61K2800/28A61P1/02A61Q11/00
Inventor 邱东李爱玲
Owner INST OF CHEM CHINESE ACAD OF SCI
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