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A preparation method of surface modified composite material for bone repair

A technology of surface modification and composite materials, which is applied in the field of polymer materials and biomaterials, can solve the problems of easy peeling off of the coating layer, cumbersome process, and limited depth, and achieve rapid mineralization ability, mild method, and good biocompatibility The effect of sexual biodegradability

Active Publication Date: 2017-12-01
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The commonly used surface modification methods include surface coating, grafting, and plasma modification. The coating layer prepared by the coating method is easy to peel off, and the process of grafting modification is very cumbersome. The plasma treatment is limited due to the limited depth. restricted

Method used

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  • A preparation method of surface modified composite material for bone repair
  • A preparation method of surface modified composite material for bone repair

Examples

Experimental program
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Effect test

Embodiment 1

[0013] Embodiment 1, the preparation of polylactic acid-polyethylene glycol-polylactic acid copolymer matrix material

[0014] Weigh 6g of recrystallized L-lactide (L-LA), add 0.176g of macromolecular initiator polyethylene glycol (Mn=2,000) into a three-necked flask, protect with nitrogen, and dissolve 0.0185g of stannous octoate After the reaction is completed, the product is dissolved in dichloromethane, precipitated with ethanol, purified repeatedly three times, and then obtained by vacuum drying. The white solid is PLA-PEG(2,000)-PLA block (PLEL) copolymer, referred to as PLEL-2K. Put the synthesized PLEL copolymers into Φ8mm×1mm stainless steel molds, preheat the molds filled with raw materials in a flat vulcanizer at 175°C for 5min, and at the same temperature, press 10MPa positive pressure for 5min to prepare PLEL Matrix material.

Embodiment 2

[0015] Embodiment 2, the preparation of surface modified composite material

[0016] Dopamine hydrochloride was dissolved in 10mM Tris·HCl buffer solution (pH=8.5) to a concentration of 4 mg / mL, while nano-hydroxyapatite (n-HA) was dispersed in the same buffer solution at the same concentration as 4mg / mL. Mix the two solutions in equal volumes, and finally immerse the PLEL matrix material ultrasonically washed with ultrapure water into the mixed solution, and react for 24 hours in a water bath constant temperature oscillator at 25°C for surface coating; after the reaction, take out the PLEL matrix material and use Ultrapure water ultrasonic washing three to four times, vacuum drying at 40 ℃ for 24h.

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Abstract

The invention provides a method for preparing a surface-modified composite material for bone repair. The present invention uses L-lactide (L-LA) as a bio-based monomer to prepare a PLA-PEG-PLA (PLEL) triblock copolymer through ring-opening polymerization; the PLEL copolymer is prepared into a PLEL matrix material by thermocompression molding , and then use dopamine / nano-hydroxyapatite (DA / n-HA) to modify the surface of the matrix material to obtain PDA / n-HA / PLEL composite material, which provides a new way for the preparation of ideal bone repair composite materials; this paper The composite material prepared by the invention has good degradability, mineralization ability and biocompatibility, and has broad application prospects in the field of bone repair materials.

Description

technical field [0001] The invention relates to a method for preparing a surface-modified composite material for bone repair. The polylactic acid-polyethylene glycol-polylactic acid block copolymer matrix material is surface-modified by using dopamine and hydroxyapatite, and deposited on the surface of the matrix. The polydopamine and hydroxyapatite biological coating belongs to the technical field of polymer materials and biological materials. technical background [0002] With the development of bone tissue engineering materials, researchers have found that the interaction between cells and materials and the properties of material surfaces have a very important impact on the repair of bone defects. Although polymer bone tissue repair materials have many advantages in application, there are still some defects, such as: poor hydrophilicity, which is not conducive to cell adhesion, proliferation and differentiation, etc. Therefore, in the field of clinical medicine, it is not...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/46A61L27/48A61L27/54
Inventor 施冬健沈佳丽张蕾李小杰陈明清
Owner JIANGNAN UNIV
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