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Self-healing hydrogel capable of promoting wound healing and cancer therapy and preparation method thereof

A technology for tumor treatment and wound healing, applied in the field of biomedical materials, can solve the problems of easy infection and healing of skin wounds, poor anti-infection ability, weak ability to inhibit cancer cells, etc., and achieve poor water solubility, convenient operation, and good biocompatibility sexual effect

Active Publication Date: 2018-08-24
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, in the prior art, there are still problems in the application of biological materials in the treatment of skin cancer, such as weak inhibitory ability to cancer cells, poor anti-infection ability, easy infection and poor healing of skin wounds, etc.

Method used

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  • Self-healing hydrogel capable of promoting wound healing and cancer therapy and preparation method thereof
  • Self-healing hydrogel capable of promoting wound healing and cancer therapy and preparation method thereof
  • Self-healing hydrogel capable of promoting wound healing and cancer therapy and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043](1) Preparation of Pluronic F127-p-toluenesulfonate (F127-OTs): Dissolve 12.3g F127 in 70mL anhydrous dichloromethane, then add 0.83mL triethylamine and 1.14g p-toluenesulfonyl chloride at room temperature Under reaction 24h. After the reaction, the organic phase was washed successively with dilute hydrochloric acid and saturated sodium bicarbonate solution, and extracted. Then, the organic phase was concentrated and precipitated in ether to obtain F127-OTs (yield 90%).

[0044] (2) Preparation of F127-p-hydroxybenzaldehyde (F127-Phe-CHO): Dissolve 2.5g of F127-OTs in 50mL of DMF, then add 0.11g of 4-hydroxybenzaldehyde and 0.12g of potassium carbonate (K 2 CO 3 ), reacted at 80°C for 72h. After the reaction was completed, after it was cooled to room temperature, 50 mL of water was added and extracted with dichloromethane. After the organic phase was dried over anhydrous magnesium sulfate, it was precipitated in ether to obtain F127-Phe-CHO (yield 90%).

[0045] (3)...

Embodiment 2

[0050] (1) Preparation of Pluronic F127-p-toluenesulfonate (F127-OTs): Dissolve 12.3g F127 in 70mL anhydrous dichloromethane, then add 0.83mL triethylamine and 1.14g p-toluenesulfonyl chloride at room temperature Under reaction 24h. After the reaction, the organic phase was washed successively with dilute hydrochloric acid and saturated sodium bicarbonate solution, and extracted. Then, the organic phase was concentrated and precipitated in ether to obtain F127-OTs (yield 90%).

[0051] (2) Preparation of F127-p-hydroxybenzaldehyde (F127-Phe-CHO): Dissolve 2.5g of F127-OTs in 50mL of DMF, then add 0.11g of 4-hydroxybenzaldehyde and 0.12g of potassium carbonate (K 2 CO 3 ), reacted at 80°C for 72h. After the reaction was completed, after it was cooled to room temperature, 50 mL of water was added and extracted with dichloromethane. After the organic phase was dried over anhydrous magnesium sulfate, it was precipitated in ether to obtain F127-Phe-CHO (yield 90%).

[0052] (3...

Embodiment 3

[0057] (1) Preparation of P123-p-toluenesulfonate (P123-OTs): Dissolve 5.8g P123 in 70mL anhydrous dichloromethane, then add 0.56mL triethylamine and 0.76g p-toluenesulfonyl chloride at room temperature Reaction 24h. After the reaction, the organic phase was washed successively with dilute hydrochloric acid and saturated sodium bicarbonate solution, and extracted. Then, the organic phase was concentrated and precipitated in ether to obtain P123-OTs (yield 87%).

[0058] (2) Preparation of P123-p-hydroxybenzaldehyde (P123-Phe-CHO): Dissolve 2 g of P123-OTs in 40 mL of DMF, then add 0.1 g of 4-hydroxybenzaldehyde and 0.11 g of potassium carbonate (K 2 CO 3 ), reacted at 80°C for 72h. After the reaction was completed, after it was cooled to room temperature, 40 mL of water was added and extracted with dichloromethane. After the organic phase was dried over anhydrous magnesium sulfate, it was precipitated in ether to obtain P123-Phe-CHO (yield 91%).

[0059] (3) Preparation o...

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Abstract

The invention discloses self-healing hydrogel capable of promoting wound healing and cancer therapy and preparation method thereof. The self-healing hydrogel is FCB hydrogel which is prepared by Schiff base reaction among a polyether-cationic polymer water solution with a mass concentration as 8% to 50%, a polyether-p-hydroxy benzaldehyde water solution with a mass concentration as 10% to 40% anda dopamine modified biological active inorganic material water solution with a mass concentration as 2% to 10%, the water solutions are mixed according to a volume ratio of (22 to 28) to (7 to 10) to(4 to 10), the F is polyether-cationic polymer, the C is polyether-p-hydroxy benzaldehyde, and the B is a dopamine modified biological active inorganic material. The self-healing hydrogel has good biological compatibility, better photo-thermal character and stronger antibacterial property; under laser radiation, the self-healing hydrogel can effectively inhibit animal cancer growth; furthermore, the self-healing hydrogel can promote mouse skin damage repair. The preparation method has the advantages of simpleness, no organic solvent residue, environment-friendly synthesizing method, convenience in operation and low raw material cost.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a self-healing hydrogel for promoting wound healing and tumor treatment and a preparation method thereof. Background technique [0002] As the largest organ of the human body, the skin plays an important role in maintaining the stability of the internal environment and also protects the body from the external environment. Skin cancer is one of the common malignant tumors in humans, and more than 1 million skin cancer patients are detected every year. The current clinical treatment strategies for skin cancer include surgical resection and later chemotherapy / radiotherapy. In order to prevent recurrence, a lot of normal skin around the tumor cells must be removed during surgical resection, resulting in large skin defects, which can easily cause wound infection and make it difficult to heal the wound. In addition, traditional chemotherapy / radiotherapy has been widely u...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K47/34A61K41/00A61P35/00A61P17/02
CPCA61K9/06A61K41/0052A61K47/34A61P17/02A61P35/00
Inventor 雷波周丽薛语萌
Owner XI AN JIAOTONG UNIV
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