A high-strength hydrogel based on a three-dimensional network scaffold and its preparation method

Abstract

The invention provides high-strength hydrogel based on a three-dimensional network support and a preparation method of the high-strength hydrogel. The high-strength hydrogel is formed by interfingering and in-situ polymerization of hydrogel and the three-dimensional network support. The method comprises the following steps: immersing the three-dimensional network support in a hydrogel prepolymer solution; enabling the hydrogel to penetrate in the three-dimensional network support after in-situ polymerization forming, and enabling an interpenetrating polymer network to be formed between the hydrogel and the support by polymerizing and winding of macromolecule long chains through support meshes. The high-strength hydrogel based on the three-dimensional network support has the advantages thatthe prepared high-strength hydrogel has excellent wear resistance and mechanical strength resisting various direction forces such as stretching, compression and shearing, and a severe biomechanical property requirement to a replaced body in a physiological environment of a using portion can be met; and the tribological property of the surface of a complex is regulated and controlled effectively,the interfacial friction coefficient is reduced, and simulation to a self-lubricating function of a hyaline cartilage of a joint is realized. The method has simple operation steps, and is low in energy consumption, the materials have good biological compatibility, and the high-strength hydrogel can be produced on the large scale.

Description

technical field [0001] The invention relates to the technical field of biomaterials, in particular to a high-strength hydrogel based on a three-dimensional network scaffold and a preparation method thereof. Background technique [0002] Hydrogels have attracted great attention due to their soft and wet properties, similar to biological tissues. Previously, hydrogels were considered as a class of materials with very weak mechanical properties and did not attract attention in structural organization. In recent years, with the improvement of their mechanical strength, hydrogels have shown their potential as structural biomaterials. potential. However, although hydrogels with existing mechanical strength show the hope of replacing part of cartilage, we need to develop higher-strength hydrogels to replace tissues with tensile and compressive strengths as high as hundreds of Pascals. Therefore, research It is of great significance to prepare hydrogels with good biocompatibility ...

AI Technical Summary

Problems solved by technology

[0006] Although a variety of hydrogel enhancement mechanisms have significantly improved its mechanical properties, the reported high-strength hydrogels have a tensile and compressive strength of about 1-20 MPa, which cannot meet the mechanical requirements of human fibrocartilage; and When the three-dimensional network scaffold is applied to human tissues, the main considerations are its biocompatibility and the proliferation and differentiation of cells on the scaffold. Some scaffolds of composite materials have high mechanical properties, but their water wettability and friction are obviously not suitable. in human soft tissue environment