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A kind of preparation method of loquat cough syrup

A technology for cough syrup and loquat, which is applied to medical preparations with no active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, etc. It can solve the problems of syrup taste impact and limited effect, so as to optimize quality and curative effect, reduce Influence and increase the effect of active ingredient content

Active Publication Date: 2021-06-01
GUIZHOU MAQIKA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the stability and shelf life of cough loquat syrup can be improved by adjusting the timing of adding bitter almonds and adding green tea extract, but at the same time, bitter almond and green tea extracts will also affect the taste and efficacy of the syrup. On the other hand Green tea extract itself also has a shelf life, and its effect is limited

Method used

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  • A kind of preparation method of loquat cough syrup
  • A kind of preparation method of loquat cough syrup
  • A kind of preparation method of loquat cough syrup

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Materials: 30g of loquat leaves, 60g of poppy shell, 10g of Baibu, 12g of Baiqian, 3g of Morus alba, 9g of bellflower, 0.1g of menthol, 600g of sucrose, 0.2g of citric acid, 5g of sodium benzoate, 1.5g of rhamnolipid

[0025] Preparation method: (1) Dry the raw materials of loquat leaves, poppy shells, basil, baiqian, morus alba, and platycodon grandiflorum, mix them, add 10 times of water, and put them in a refrigerator for 12 hours at 0-5°C;

[0026] (2) Take out the product obtained in step (1), add a surfactant, and sonicate for 20 minutes to obtain an extract, filter, heat and concentrate the filtrate and store it at room temperature until use;

[0027] (3) Take sucrose and add 50% of the total amount of water, heat and mix evenly, then add citric acid and sodium benzoate to obtain a sucrose mixed solution;

[0028] (4) Menthol and essence are dissolved in an appropriate amount of ethanol to obtain ethanol solution;

[0029] (5) Mix the extract in step (2), the su...

Embodiment 2

[0031] Materials: 70g of loquat leaf, 40g of poppy shell, 25g of Baibu, 5g of Baiqian, 9g of Morus alba, 3g of bellflower, 0.5g of menthol, 400g of sucrose, 0.4g of citric acid, 1g of sodium benzoate, 2.5g of rhamnolipid

[0032] Preparation method: (1) Dried raw materials such as loquat leaves, poppy shells, barley, baiqian, morus alba, and platycodon grandiflora, mixed, added 15 times of water, and then placed in a refrigerator for 20 hours at 0-5°C;

[0033] (2) Take out the product obtained in step (1), add a surfactant, and ultrasonicate for 20-45 minutes to obtain the extract, filter, heat and concentrate the filtrate and store it at room temperature until use;

[0034] (3) Take sucrose and add 50% of the total amount of water, heat and mix evenly, then add citric acid and sodium benzoate to obtain a sucrose mixed solution;

[0035] (4) Menthol and essence are dissolved in an appropriate amount of ethanol to obtain ethanol solution;

[0036] (5) Mix the extract in step ...

Embodiment 3

[0038] Materials: 69g of loquat leaves, 50g of poppy shell, 15g of Baibu, 9g of Baiqian, 6g of Morus alba, 6g of bellflower, 0.15g of menthol, 600g of sucrose, 0.3g of citric acid, 2.5g of sodium benzoate, 2.0 g of rhamnolipid g

[0039] Preparation method: (1) Dry the raw materials of loquat leaves, poppy shells, basil, baiqian, morus alba, and platycodon grandiflora, mix them, add 12 times of water, and put them in a refrigerator for 24 hours at 0-5°C;

[0040] (2) Take out the product obtained in step (1), add a surfactant, and sonicate for 30 minutes to obtain an extract, filter, heat and concentrate the filtrate and store it at room temperature until use;

[0041] (3) Take sucrose and add 50% of the total amount of water, heat and mix evenly, then add citric acid and sodium benzoate to obtain a sucrose mixed solution;

[0042] (4) Menthol and essence are dissolved in an appropriate amount of ethanol to obtain ethanol solution;

[0043] (5) Mix the extract in step (2), the...

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Abstract

The present invention relates to the field of medicine production, and specifically refers to a preparation method of loquat cough syrup, which specifically includes the following steps: (1) drying and pulverizing raw materials such as loquat leaves, poppy shells, basilica, baipei, morus alba, and platycodon grandiflorum, Mix, add water and refrigerate; (2) take out the product after refrigerating, add a surfactant, ultrasonically obtain the extract, filter, heat and concentrate the filtrate and store it at room temperature for later use; (3) take sucrose and add water, After heating and mixing evenly, add citric acid and sodium benzoate to obtain a sucrose mixed solution; (4) dissolve menthol and essence in ethanol to obtain an ethanol solution; (5) mix the extract, sucrose mixed solution and ethanol solution, Stir, stand still, filter, add water to the full amount, and mix well to obtain the target product. The invention achieves antibacterial and solubilizing effects by increasing the concentration of flavonoids and controlling the concentration of surfactants, and optimizes the quality and curative effect of the syrup; in addition, flavonoids are the original substances in the syrup, and rhamnolipids are also used in the food and drug industry , neither will have any adverse effect on the syrup.

Description

technical field [0001] The invention relates to the field of medicine production, in particular to a preparation method of loquat cough syrup. Background technique [0002] Syrup refers to the concentrated sucrose aqueous solution of medicinal material extracts or aromatic substances. It is one of the commonly used clinical dosage forms because of its simple preparation process, convenient administration, and rapid effect; in addition, because the sugar and aroma contained in the syrup have The taste-correcting effect can cover up the bitter and salty smell of certain medicines, improve the taste, and make the medicines easy to take. Therefore, it is very popular among doctors and patients, especially children. However, in the actual production and storage process, due to the solubility of the raw material extracts and the bacteria introduced in the sucrose, the stability of many syrups with definite curative effects is easily affected, which further affects the curative eff...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K36/904A61K47/26A61P11/14A61K31/045
CPCA61K9/0095A61K31/045A61K36/27A61K36/346A61K36/605A61K36/66A61K36/73A61K36/904A61K47/26A61K2236/331A61P11/14A61K2300/00
Inventor 张芝庭张涛涛
Owner GUIZHOU MAQIKA PHARMA
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