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Preparation method for porous calcium phosphate stent

A porous scaffold and calcium phosphate technology, applied in the field of biomedical materials, can solve the problems of reducing energy consumption, pore shrinkage and deformation, etc., and achieve the effects of reducing energy consumption, easy acquisition, and simple process operation

Active Publication Date: 2018-10-12
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a calcium phosphate porous scaffold method for the deficiencies of the prior art, so as to avoid problems such as scaffold size and pore shrinkage and deformation caused by high-temperature sintering, and to obtain fine, accurate and individualized morphological dimensions and microstructures. Regulated scaffold material while reducing energy consumption

Method used

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  • Preparation method for porous calcium phosphate stent
  • Preparation method for porous calcium phosphate stent
  • Preparation method for porous calcium phosphate stent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] (1) Preparation of printing paste

[0037] Weigh polycaprolactone PCL and dissolve it in acetone to prepare a PCL solution with a concentration of 0.032g / mL, mix calcium hydrogen phosphate DCPD and tetracalcium phosphate TTCP powder at a molar ratio of 1:1 to obtain TTCP / DCPD mixed powder , mixing the obtained mixed powder with the PCL solution to make a suspension with a mixed powder content of 1 mg / ml, which is used as a slurry for 3D printing;

[0038] (2) Preparation of calcium phosphate porous scaffolds by 3D printing

[0039]The slurry obtained in step (1) is subjected to 3D printing, the moving speed of the nozzle is controlled to be 240mm / min, the discharge speed is 0.167mL / min, and the length, width and height are respectively 20mm, 20mm, 10mm rectangular parallelepiped DCPD / TTCP / PCL stent body (see figure 1 ), according to the required pore size of the bracket during printing, the movement of the nozzle is controlled by setting the 3D printing program. Soak...

Embodiment 2

[0044] (1) Preparation of printing paste

[0045] Weigh polycaprolactone PCL and dissolve it in acetone to prepare a PCL solution with a concentration of 0.064g / mL, mix calcium hydrogen phosphate DCPD and tetracalcium phosphate TTCP powder at a molar ratio of 1:1 to obtain TTCP / DCPD mixed powder , mixing the obtained mixed powder with the PCL solution to make a suspension with a mixed powder content of 2 mg / ml, which is used as a slurry for 3D printing;

[0046] (2) Preparation of calcium phosphate porous scaffolds by 3D printing

[0047] The slurry obtained in step (1) is subjected to 3D printing and molding, the moving speed of the nozzle is controlled to 220mm / min, the discharge speed is 0.167mL / min, and the length, width and height are respectively 20mm, 20mm, For the 10mm rectangular parallelepiped DCPD / TTCP / PCL stent body, according to the required pore size of the stent during printing, the printing is completed by setting the 3D printing program and controlling the no...

Embodiment 3

[0049] (1) Preparation of printing paste

[0050] Weigh polycaprolactone PCL and dissolve it in acetone to prepare a PCL solution with a concentration of 0.064g / mL, mix calcium hydrogen phosphate DCPD and tetracalcium phosphate TTCP powder at a molar ratio of 1:1 to obtain TTCP / DCPD mixed powder , mixing the obtained mixed powder with the PCL solution to make a suspension with a mixed powder content of 1.5 mg / ml, which is used as a slurry for 3D printing;

[0051] (2) Preparation of calcium phosphate porous scaffolds by 3D printing

[0052] The slurry obtained in step (1) is subjected to 3D printing, the moving speed of the nozzle is controlled to be 240mm / min, the discharge speed is 0.167mL / min, and the length, width and height are respectively 20mm, 20mm, 10mm rectangular parallelepiped DCPD / TTCP / PCL stent body. When printing, according to the required pore size of the bracket, the printing is completed by setting the 3D printing program and controlling the movement of the...

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Abstract

The invention provides a preparation method for a porous calcium phosphate stent. The preparation method comprises the following steps: with polycaprolactone (PCL) as a printing template, dissolving polycaprolactone in acetone so as to obtain a polycaprolactone solution, and uniformly mixing a mixture of tetracalcium phosphate (TTCP) and calcium hydrogen phosphate (DCPD) with the above polycaprolactone solution to prepare printing slurry; subjecting the slurry to 3D printing to print a green stent body with a certain shape and of a certain structure, and placing the stent in a low-temperaturehydration environment for a reaction so as to form a hydroxyapatite HAp porous stent, thereby avoiding dimensional shrinkage deformation caused by high-temperature sintering and reducing energy loss;and finally, putting the porous stent in acetone to dissolve and remove the stent template PCL so as to obtain the individually-controllable porous calcium phosphate stent with HAp as a main componentand with certain osteoinductivity and mechanical strength.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to the preparation of calcium phosphate porous supports. Background technique [0002] At present, tissue engineering technology is widely used in the field of bone repair. Porous scaffold materials can provide a place for cells to adhere and grow, induce cell proliferation and differentiation, and thus promote tissue regeneration in the human body. Calcium phosphate is the main inorganic component of human bones. Calcium phosphate porous scaffolds have good biocompatibility, osteoinductivity, and degradability, and can achieve the purpose of bone tissue repair and regeneration. However, in the traditional method of preparing calcium phosphate porous scaffolds, the preforming process and sintering process often have the following defects: poor plasticity, it is difficult to meet the requirements of the defect site for morphological complexity and dimensional accuracy...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B29C64/10B29C64/314B29C64/379A61L27/12A61L27/56B33Y10/00B33Y40/00
CPCA61L27/12A61L27/56A61L2400/08A61L2430/02B29C64/10B29C64/314B29C64/379B33Y10/00B33Y40/00
Inventor 孙静张小凤
Owner SICHUAN UNIV
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