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Preparation method of polyvinyl alcohol hydrogel

A polyvinyl alcohol and hydrogel technology, which is applied in the field of preparation of polyvinyl alcohol hydrogel, can solve the problems of high viscosity, water absorption rate, water absorption rate performance influence, and cross-linking reaction cannot be carried out uniformly, and achieves water absorption rate. And the effect of increasing water absorption rate and uniform crosslinking degree

Pending Publication Date: 2018-10-16
NINGBO BAOTING BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

To prepare highly hydrophilic polyvinyl alcohol hydrogels, at present, cross-linking reactions occur between side group functional groups on polyvinyl alcohol long-chain molecules to prepare polyvinyl alcohol hydrogels, but because polymer solutions usually The viscosity is very high, resulting in the inability of the cross-linking reaction to proceed uniformly and affecting the stability of the polyvinyl alcohol hydrogel, resulting in its water absorption rate, water absorption rate and other properties being affected

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Embodiment one: a kind of preparation method of polyvinyl alcohol hydrogel comprises the following specific steps:

[0013] (1) Add vinyl acetate and diethyl diallylmalonate into the reaction flask at a mass ratio of 1:10, then add dimethylformamide, mix well, and control the reaction by vinyl acetate and diene The mass concentration of the mixture that diethyl propyl malonate is formed is 5%, then add azobisisoheptanonitrile, control the mass ratio of azobisisoheptanonitrile and vinyl acetate to be 0.1%, and at 60 ℃ Reaction at high temperature for 20 hours to obtain polyvinyl acetate;

[0014] (2) Add potassium hydroxide and deionized water to the above polyvinyl acetate, control the mass ratio of potassium hydroxide to vinyl acetate to be 1:1, and the mass ratio of deionized water to dimethylformamide to be 1 : 20, stirred at a temperature of 80° C. for 20 hours, then added 10 times the total volume of deionized water and dialyzed to remove the solvent dimethylforma...

Embodiment 2

[0015] Embodiment two: a kind of preparation method of polyvinyl alcohol hydrogel comprises the following concrete steps:

[0016] (1) Add vinyl acetate and N,N-methylenebisacrylamide into the reaction flask at a mass ratio of 1:30, then add dimethylformamide, mix well, and control the reaction by vinyl acetate and N, The mass concentration of the mixture composed of N-methylenebisacrylamide is 15%, then add benzoyl peroxide, control the mass ratio of benzoyl peroxide and vinyl acetate to be 1.0%, and at a temperature of 80°C Reacted for 15 hours to obtain polyvinyl acetate;

[0017] (2) Add potassium hydroxide and deionized water to the above polyvinyl acetate, control the mass ratio of potassium hydroxide to vinyl acetate to be 1:4, and the mass ratio of deionized water to dimethylformamide to be 1 : 10, stirred at a temperature of 50° C. for 48 hours, then added 5 times the total volume of deionized water and dialyzed to remove the solvent dimethylformamide to obtain polyv...

Embodiment 3

[0018] Embodiment three: a kind of preparation method of polyvinyl alcohol hydrogel comprises the following specific steps:

[0019] (1) Add vinyl acetate and N,N′-(1,2-dihydroxyethylene) diacrylamide into the reaction flask at a mass ratio of 1:50, then add dimethylformamide, mix well, and control The mass concentration of the mixture composed of vinyl acetate and N,N'-(1,2-dihydroxyethylene) diacrylamide is 20%, and then potassium persulfate is added to control the mass ratio of potassium persulfate to vinyl acetate to 0.6%, and reacted at a temperature of 100°C for 10 hours to obtain polyvinyl acetate;

[0020] (2) Add potassium hydroxide and deionized water to the above polyvinyl acetate, control the mass ratio of potassium hydroxide to vinyl acetate to 1:3, and control the mass ratio of deionized water to dimethylformamide to 1 : 16, stirred at a temperature of 70° C. for 40 hours, then added 8 times the total volume of deionized water and dialyzed to remove the solvent ...

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PUM

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Abstract

The invention discloses a preparation method of polyvinyl alcohol hydrogel. The preparation method comprises the following steps: adding a crosslinking agent in the synthesis process of polyvinyl acetate to carry out cross-linking reaction and enabling the crosslinking agent to uniformly enter a macromolecule chain of the polyvinyl acetate to obtain a uniform polyvinyl acetate crosslinking copolymer; then hydrolyzing by using strong base to obtain the polyvinyl alcohol hydrogel with a uniform crosslinking degree. The whole reaction is uniformly and stably carried out, so that the obtained polyvinyl acetate has uniform crosslinking degree; the crosslinking degree of the polyvinyl alcohol prepared from the polyvinyl acetate with the uniform crosslinking degree is more uniform; in addition, water absorption and water absorption rate of polyvinyl alcohol hydrogel prepared according to the method are greatly improved than those of hydrogel prepared by a traditional method.

Description

technical field [0001] The invention relates to a preparation method of a hemostatic material in the medical field, in particular to a preparation method of a polyvinyl alcohol hydrogel. Background technique [0002] Polyvinyl alcohol hydrogel is widely used as medical dressing and hemostatic material because of its high water absorption rate, fast water absorption rate and excellent biocompatibility. Polyvinyl alcohol is obtained by hydrolysis of polyvinyl acetate. According to the degree of alcoholysis, the water solubility of polyvinyl alcohol varies greatly. Polyvinyl alcohol with excessive alcoholysis makes it insoluble in water due to the strong hydrogen bond interaction between molecules and molecules. To prepare highly hydrophilic polyvinyl alcohol hydrogels, at present, cross-linking reactions occur between side group functional groups on polyvinyl alcohol long-chain molecules to prepare polyvinyl alcohol hydrogels, but because polymer solutions usually The viscos...

Claims

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Application Information

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IPC IPC(8): C08L31/04C08J3/075C08F218/08C08F222/14
CPCC08F218/08C08J3/075C08J2331/04C08F222/14
Inventor 竺亚斌何斌
Owner NINGBO BAOTING BIOTECHNOLOGY CO LTD