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A kind of hair growth composition and its liposome preparation method

A composition and liposome technology, applied in the field of hair growth composition and liposome preparation, can solve the problems of being unsuitable for heat-sensitive active ingredients, high temperature in the preparation process, harmful solvent residue, etc., and achieve no harmful solvent residue, Low preparation temperature and good stability

Active Publication Date: 2021-06-11
PROYA COSMETICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The traditional preparation methods of liposomes include film dispersion method, pH gradient method, ultrasonic method, high-pressure homogenization method, etc., but these methods have disadvantages such as complicated operation, residual harmful solvents, high temperature in the preparation process, and are not suitable for the preparation of heat-sensitive active ingredients.

Method used

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  • A kind of hair growth composition and its liposome preparation method
  • A kind of hair growth composition and its liposome preparation method
  • A kind of hair growth composition and its liposome preparation method

Examples

Experimental program
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Embodiment 1

[0046] A preparation method of hair growth composition liposome, adopting the following steps:

[0047] Step 1: Weigh ligustrazine, panax notoginseng saponins, tanshinone Ⅱ A, thymol, adenosine, tripeptide-1 copper and fructose diphosphate tri Sodium, mixed as a hair growth composition;

[0048] Step 2: Weigh 6.4% hair growth composition, 9.6% phospholipid emulsifier, 4% phytosterol, 20% ethanol, 60% water by weight, and mix the hair growth composition, phospholipid emulsifier, phytosterol, ethanol, water After mixing, use an ultrasonic disperser at room temperature until no solid particles are visible to the naked eye to obtain a mixed dispersion;

[0049] Step 3: Add the mixed dispersion liquid obtained in step 2 into the supercritical reactor, the supercritical fluid used is carbon dioxide, inject the liquefied and pressurized carbon dioxide into the reactor, and keep the fluid temperature in the supercritical reactor at 25-35°C and the pressure at 10 -30MPa, carbon dioxi...

Embodiment 2

[0052] A preparation method of hair growth composition liposome, adopting the following steps:

[0053] Step 1: Weigh ligustrazine, panax notoginseng saponins, tanshinone Ⅱ A, thymol, adenosine, tripeptide-1 copper and fructose diphosphate tri Sodium, mixed as a hair growth composition;

[0054] Step 2: Weigh 6% hair growth composition, 15% phospholipid emulsifier, 8% phytosterol, 15% ethanol, 56% water by weight, and mix the hair growth composition, phospholipid emulsifier, phytosterol, ethanol, water After mixing, use an ultrasonic disperser at room temperature until no solid particles are visible to the naked eye to obtain a mixed dispersion;

[0055] Step 3: Add the mixed dispersion liquid obtained in step 2 into the supercritical reactor, the supercritical fluid used is carbon dioxide, inject the liquefied and pressurized carbon dioxide into the reactor, and keep the fluid temperature in the supercritical reactor at 25-35°C and the pressure at 10 -30MPa, carbon dioxide ...

Embodiment 3

[0058] A preparation method of hair growth composition liposome, adopting the following steps:

[0059] Step 1: Weigh ligustrazine, panax notoginseng saponins, tanshinone ⅡA, thymol, adenosine, tripeptide-1 copper and fructose diphosphate tri Sodium, mixed as a hair growth composition;

[0060] Step 2: Weigh 7% hair growth composition, 5% phospholipid emulsifier, 3% phytosterol, 30% ethanol, 55% water by weight, and mix the hair growth composition, phospholipid emulsifier, phytosterol, ethanol, water After mixing, use an ultrasonic disperser at room temperature until no solid particles are visible to the naked eye to obtain a mixed dispersion;

[0061] Step 3: Add the mixed dispersion liquid obtained in step 2 into the supercritical reactor, the supercritical fluid used is carbon dioxide, inject the liquefied and pressurized carbon dioxide into the reactor, and keep the fluid temperature in the supercritical reactor at 25-35°C and the pressure at 10 -30MPa, carbon dioxide ci...

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Abstract

The present invention relates to a hair growth composition and a liposome preparation method thereof, characterized in that: the hair growth composition consists of ligustrazine, notoginseng saponins, tanshinone IIA, thymol, adenosine, tripeptide-1 Copper and trisodium fructose diphosphate are composed in a mass ratio of 0.5-2:2:1.5:0.2:0.1:0.05-0.2:0.5. A preparation method of a hair growth composition liposome, which adopts the following steps: A, weigh ligustrazine, total saponins of Panax notoginseng, tanshinone IIA, thymol, adenosine, tripeptide-1 copper and fructose diphosphate Trisodium is used as a hair growth composition; B, after mixing the hair growth composition, phospholipid emulsifier, phytosterol, ethanol, and water, ultrasonically assisted dispersion to obtain a mixed dispersion; C, adding the mixed dispersion to a super The critical reaction kettle uses supercritical carbon dioxide as the fluid, and circulates for 45-60 minutes; D, quickly releases carbon dioxide until the kettle is reduced to normal pressure, and the hair growth composition liposome is obtained. The invention has the beneficial effects of good hair growth effect, good stability, low preparation temperature and no harmful solvent residue.

Description

technical field [0001] The invention relates to the technical field of cosmetic preparations, in particular to a hair growth composition and a method for preparing liposomes thereof. Background technique [0002] With the acceleration of the pace of society and the arrival of an aging society, hair loss has become a hot issue for consumers. Hair loss includes stress alopecia, androgenetic alopecia, alopecia areata, and female hair loss. The traditional theory of traditional Chinese medicine holds that "the liver controls hair growth". Therefore, traditional Chinese medicine prescriptions for hair growth and hair growth often treat hair loss by regulating the liver and nourishing blood. Commonly used medicinal materials include Chuanxiong, Danshen, Sanqi, and Baizhi. Modern biomedical science has discovered some different causes of hair loss through research, such as excessive androgen, strong oil secretion, and poor microcirculation. Treat hair loss. [0003] Based on the ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/9789A61K8/14A61K8/34A61K8/49A61K8/60A61K8/63A61K8/64A61P17/14A61Q7/00
CPCA61K8/14A61K8/347A61K8/494A61K8/60A61K8/63A61K8/64A61Q7/00A61K8/9789A61P17/14
Inventor 王晗宁蒋丽刚毕永贤黄洁芳刘红艳王晓
Owner PROYA COSMETICS