Preparation method of magnesium/L-polylactic acid composite bone scaffold

A technology of L-polylactic acid and bone scaffold, which is applied in medical science, tissue regeneration, prosthesis, etc., can solve the problems of reducing the mechanical properties of composite materials, difficult interface bonding, and the difference in physical and chemical properties between metal Mg and polymer PLLA. Improve interface binding ability, improve mechanical properties, and improve the effect of mechanical properties

Active Publication Date: 2018-11-02
西安勃奥生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the physical and chemical properties of metal Mg and polymer PLLA are very different, which makes it difficult to form a strong interfacial bond between Mg and PLLA, thereby reducing the mechanical properties of the composite.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Use the 3D design software to design the personalized shape and internal porous structure of the composite bone scaffold, import the designed 3D data model into the computer for layered slice processing, and obtain the cross-sectional profile information of each layer. Weigh 4.25 grams of PLLA powder, 0.50 grams of Mg powder and 0.25 grams of PL powder, respectively, add the three into a beaker filled with 30 ml of absolute ethanol in turn, and mix them evenly by ultrasonic dispersion and magnetic stirring. Use filter paper to filter the mixed suspension, dry it in an electric blast drying oven, and then grind the dried mixed powder, put the ground mixed powder in a selective laser sintering system for sintering experiments, according to the pre-designed Structural requirements, under the conditions of laser power 2.5W, scanning speed 110mm / min, scanning distance 1mm, and spot diameter 0.5mm, use laser to selectively sinter the mixed powder and prepare PLLA / Mg composite ...

Embodiment 2

[0026]Use the 3D design software to design the personalized shape and internal porous structure of the composite bone scaffold, import the designed 3D data model into the computer for layered slice processing, and obtain the cross-sectional profile information of each layer. Weigh 4.25 g of PLLA powder, 0.63 g of Mg powder and 0.12 g of PL powder, respectively, add the three into a beaker filled with 30 ml of absolute ethanol, and mix them evenly by ultrasonic dispersion and magnetic stirring. Use filter paper to filter the mixed suspension, dry it in an electric blast drying oven, and then grind the dried mixed powder, put the ground mixed powder in a selective laser sintering system for sintering experiments, according to the pre-designed Structural requirements, under the conditions of laser power 2.5W, scanning speed 110mm / min, scanning distance 1mm, and spot diameter 0.5mm, use laser to selectively sinter the mixed powder and prepare PLLA / Mg composite bone scaffold. At th...

Embodiment 3

[0028] Use the 3D design software to design the personalized shape and internal porous structure of the composite bone scaffold, import the designed 3D data model into the computer for layered slice processing, and obtain the cross-sectional profile information of each layer. Weigh 4.25 g of PLLA powder, 0.12 g of Mg powder and 0.63 g of PL powder, respectively, add the three into a beaker filled with 30 ml of absolute ethanol, and mix them evenly by ultrasonic dispersion and magnetic stirring. Use filter paper to filter the mixed suspension, dry it in an electric blast drying oven, and then grind the dried mixed powder, put the ground mixed powder in a selective laser sintering system for sintering experiments, according to the pre-designed Structural requirements, under the conditions of laser power 2.5W, scanning speed 110mm / min, scanning distance 1mm, and spot diameter 0.5mm, use laser to selectively sinter the mixed powder and prepare PLLA / Mg composite bone scaffold. At t...

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PUM

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Abstract

The invention discloses a preparation method of a magnesium / L-polylactic acid composite bone scaffold. The preparation method comprises the following steps: mixing L-polylactic acid powder, magnesiumpowder and amphiphilic phospholipid powder are mixed through liquid phase mixing, then performing solid-liquid separation, and drying and grinding a solid to obtain composite powder; preparing the composite bone scaffold from the composite powder through a selective laser sintering technology. By the preparation method, due to relatively good binding ability between amphiphilic molecular phospholipid and metal magnesium and between the amphiphilic molecular phospholipid and L-polylactic acid, interfacial performance between the metal magnesium and a polymer L-polylactic acid is improved, and the biological properties and the mechanical properties of the magnesium / L-polylactic acid composite bone scaffold are improved.

Description

technical field [0001] The invention relates to a preparation method of a magnesium / L-polylactic acid composite bone scaffold, in particular to a method for preparing a magnesium / L-polylactic acid composite bone scaffold by using amphiphilic phospholipids to improve the binding performance of magnesium and L-polylactic acid, which belongs to the bone scaffold preparation technology field. Background technique [0002] Poly-L-lactic acid (PLLA) is a typical representative of biodegradable polymers for clinical application. Due to its renewable source, controllable synthesis, good mechanical properties and biocompatibility, it has become a hotspot in the research of bone implant materials. Magnesium (Mg) has attracted more and more attention due to its self-degradation and absorption in the human body, and its good biomechanical compatibility with human bones. Therefore, Mg / PLLA composites may have the advantages of both materials, S.C.Cifuentes et al. prepared PLA / Mg composi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/44A61L27/58
CPCA61L27/446A61L27/58A61L2430/02C08L67/04
Inventor 帅词俊冯佩彭淑平王国勇叶恒云
Owner 西安勃奥生物科技有限公司
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