Hydrogen-bonded organic framework materials based on fused ring ligands, their preparation methods and applications

Abstract

The invention belongs to the field of porous organic materials and in particular discloses a hydrogen bond organic framework material based on condensed ring ligand construction as well as a preparation method and application thereof. The material is prepared by taking condensed ring ligands as an organic framework by utilizing a synergistic effect of pi-pi interaction of multiple hydrogen bonds and condensed ring ligands. The condensed ring ligands are selected from carboxyl-containing poly-benzene ring conjugated aromatic hydrocarbons, and the particle size of the material is 200nm to 50 microns. The organic framework material has the characteristics of being high in specific surface area, permanent in pore channel, high in chemical and thermal stability, mild in synthesis conditions andexcellent in singlet oxygen production capacity and the like. Moreover, the material is simple in preparation method, high in operability and capable of freely controlling the particle size of particles. The material has excellent biocompatibility and low biotoxicity, has excellent compound chemical-photodynamic therapy capacity after further compounding anti-cancer drugs, and achieves an excellent cancer treatment effect, and the cancer cell survival rate is low.

Description

technical field [0001] The invention belongs to the field of porous organic materials, and relates to a hydrogen bond organic framework material constructed based on fused ring ligands, in particular to a hydrogen bond organic framework material constructed based on condensed ring ligands, its preparation method and application. Background technique [0002] Hydrogen-bonded organic framework materials (HOFs for short), because of their large specific surface area, good reproducibility and mild synthesis conditions, have shown excellent application prospects in the fields of gas storage / separation, proton conduction, etc., but their stability The low characteristics limit the development of its application. [0003] Cancer kills millions of people every year and is a growing threat to human health. Chemotherapy is still the most common cancer treatment. However, the inherent limitations of chemotherapy, including poor side effects, poor pharmacokinetics, and poor biodistrib...

AI Technical Summary

Problems solved by technology

[0004] The invention provides a hydrogen-bonded organic framework material based on fused-ring ligands. The material utilizes the synergistic effect of multiple hydrogen bonds and the π-π interaction force of the fused-ring ligands to solve the problem of poor stability of hydrogen-bonded organic framework materials in the past. , the problem of not being able to maintain a permanent channel, and making the material have excellent chemical and thermal stability, and can realize the restoration of crystal state and specific surface area in an acidic environment

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