Application of flavonoid products in preparation of drug for treating cancer and inhibitor

A technology of flavonoids and inhibitors, which is applied in the application field of flavonoids products as preparation of cancer drugs and inhibitors, and can solve the problem of no new class of inhibitors

Inactive Publication Date: 2018-11-06
TIANJIN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, no new classes of inhibitors have been reported and adequately studied

Method used

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  • Application of flavonoid products in preparation of drug for treating cancer and inhibitor
  • Application of flavonoid products in preparation of drug for treating cancer and inhibitor
  • Application of flavonoid products in preparation of drug for treating cancer and inhibitor

Examples

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Embodiment Construction

[0017] The present invention is further described below in conjunction with specific examples. The methods involved in the following examples are conventional methods unless otherwise specified.

[0018] The application of a flavonoid natural product as an inhibitor for the preparation of drugs for treating cancer, in order to verify the above application, the following related experiments and tests are provided.

[0019] 1. Materials and sample preparation:

[0020] Buy Myricetin, Dihydromyricetin, Quercetin, Taxifolin, Isoquercetin, Luteolin, Fisetin, Kaempferol, Apigenin, Genistein from Aladdin Biochemical Technology Co., Ltd. (China) Flavonoids, isoliquiritigenin, galangin, morin, gallic acid. Rhamnetin was purchased from Sigma-Aldrich (USA). Rutin was purchased from Soleibao (China). (+)-catechin and (-)-epicatechin were purchased from Bailingwei Technology Co., Ltd. (China). Orange and methyl methanesulfonate (MMS) were purchased from Sigma-Aldrich (USA). All DNA ...

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Abstract

The invention relates to an application of flavonoid products in preparation of a drug for treating cancer and an inhibitor. The flavonoid products are myricetin, a dihydroxylation form of myricetin or a dihydroxylation form of quercetin, and an Mg<2+> preparation is used during application. The bioactive range of natural flavonoid on the enzyme level is extended, and a road is paved for developing flavonoid assisted targeted cancer treatment. Besides, great research space exists in researching the function of myricetin on 5'-ribozyme family and combination of myricetin with other drugs to target DDR (DNA damage response) for cancer treatment.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine research, and in particular relates to the application of a flavonoid product as a medicine for treating cancer and an inhibitor. Background technique [0002] Human flap endonuclease (hFEN1), as a typical member of the 5'-nuclease superfamily, is a metal ion-dependent and structure-specific nuclease. It removes 5' single-stranded overhangs, called flaps created by lagging strand synthesis of DNA replication or strand displacement reactions in base excision repair (BER). Oligonucleotide cleavage performed by hFEN1 generates 5' phosphorylated ends suitable for ligation, ensuring genomic stability. Importantly, human malignancies are characterized by rapid and unlimited DNA replication, which requires hyperactivated DNA repair systems to recover errors accumulated during this process. Indeed, hFEN1 is overexpressed in various human cancers, so hFEN1 may be considered as a biomarker for ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61K33/00A61P35/00
CPCA61K31/352A61K33/00A61P35/00A61K2300/00
Inventor 马龙张博韬王莹孟媛媛
Owner TIANJIN UNIV OF SCI & TECH
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