ae1d active peptide and its preparation method and application

A technology of active peptide, 1.ae1d, which is applied to the preparation method of peptides, chemical instruments and methods, peptides, etc., can solve the problems of high technical threshold and low degree of product homogeneity
CN108794582BActive Publication Date: 2021-12-14INST OF ANIMAL SCI OF CHINESE ACAD OF AGRI SCI
5 Cites 0 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
INST OF ANIMAL SCI OF CHINESE ACAD OF AGRI SCI
Publication Date
2021-12-14

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention belongs to the technical field of polypeptide preparation, and specifically discloses the Ae1d active peptide and its preparation method and application. The present invention provides an ideal recombinant expression scheme for Ae1d using Escherichia coli by selecting a suitable expression strain and a suitable carrier and adopting an automatic induction method. This method can stably obtain 0.55 mg / L highly pure recombinant Ae1d (rAe1d), the amino acid sequence of which is shown in SEQ ID NO.11. rAe1d can significantly inhibit voltage-sensitive potassium channel (VGPC) current on rat DRG cells at 0.5 μM level.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention belongs to the technical field of polypeptide preparation, in particular, it relates to Ae1d active peptide and its preparation method and application. Background technique

[0002] Compared with small molecular drugs, peptide drugs have better selectivity and no accumulation in the body, and are more and more favored by major pharmaceutical companies. Ants, as a species as old as dinosaurs, record the use of ants for treating diseases in "Compendium of Materia Medica", and also have detailed descriptions in the dictionary "Erya". Ants have very high medicinal value, and are called micro-animal nutrition treasure house and natural medicine processing plant, which can not only keep fit but also cure diseases, and are very suitable for development and utilization as a new medicinal resource. But at present, the development of ants is only limited to the whole medicine, and the biological activity of its single component has not been studie...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More