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Stock solution for wrapping stem cell growth factors

A growth factor and stem cell technology, applied in the direction of cosmetics, cosmetic preparations, dressing preparations, etc., can solve the problems of exogenous pollution such as endotoxin, achieve good transdermal absorption capacity, prolong shelf life, and tender skin Effect

Inactive Publication Date: 2018-11-16
天津赛尔康生物医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The traditional preservation method only needs to be freeze-dried powder, but stem cell growth factor cannot solve the problems of endotoxin and exogenous pollution in the process of freeze-dried powder

Method used

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  • Stock solution for wrapping stem cell growth factors
  • Stock solution for wrapping stem cell growth factors
  • Stock solution for wrapping stem cell growth factors

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A stock solution of encapsulated stem cell growth factor:

[0024] (1) Encapsulated stem cell growth factor stock solution includes: high molecular weight sodium hyaluronate 17%, medium molecular weight sodium hyaluronate 12%, low molecular weight sodium hyaluronate 5.8%, propylene glycol 25%, glycerin 35%, PE90102 .0% and sterile water 3.2%; (the molecular weight of the high molecular weight sodium hyaluronate is greater than 400,000; the molecular weight of the middle molecular weight sodium hyaluronate is 200,000-400,000; the molecular weight of the low molecular weight sodium hyaluronate less than 10,000)

[0025] (2) The preparation method of the stock solution of encapsulated stem cell growth factor: first mix high molecular weight sodium hyaluronate, medium molecular weight sodium hyaluronate and low molecular weight sodium hyaluronate according to the proportion, after swelling, heat to 42°C and stir evenly; Then add propylene glycol and glycerin respectively, ...

Embodiment 2

[0031] A stock solution of encapsulated stem cell growth factor:

[0032] (1) The stock solution of encapsulated stem cell growth factor includes: high molecular weight sodium hyaluronate 20%, medium molecular weight sodium hyaluronate 10%, low molecular weight sodium hyaluronate 5.5%, propylene glycol 22%, glycerin 38%, PE90101 in terms of mass percentage .8% and sterile water 2.7%; (the molecular weight of the high molecular weight sodium hyaluronate is greater than 400,000; the molecular weight of the middle molecular weight sodium hyaluronate is 200,000-400,000; the molecular weight of the low molecular weight sodium hyaluronate less than 10,000)

[0033](2) The preparation method of the stock solution of encapsulated stem cell growth factor: first mix high molecular weight sodium hyaluronate, medium molecular weight sodium hyaluronate and low molecular weight sodium hyaluronate according to the proportion, after swelling, heat to 42°C and stir evenly; Then add propylene ...

Embodiment 3

[0039] A stock solution of encapsulated stem cell growth factor:

[0040] (1) Encapsulated stem cell growth factor stock solution includes: 20% high molecular weight sodium hyaluronate, 10% medium molecular weight sodium hyaluronate, 5% low molecular weight sodium hyaluronate, 20% propylene glycol, 40% glycerin, PE9010 2% and sterile water 3%; (the molecular weight of the high molecular weight sodium hyaluronate is greater than 400,000; the molecular weight of the middle molecular weight sodium hyaluronate is 200,000-400,000; the molecular weight of the low molecular weight sodium hyaluronate is less than 10,000)

[0041] (2) The preparation method of the stock solution of encapsulated stem cell growth factor: first mix high molecular weight sodium hyaluronate, medium molecular weight sodium hyaluronate and low molecular weight sodium hyaluronate according to the proportion, after swelling, heat to 42°C and stir evenly; Then add propylene glycol and glycerin respectively, the...

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Abstract

The invention discloses a stock solution for wrapping stem cell growth factors, belonging to the technical field of biomaterials. The stock solution for wrapping stem cell growth factors comprises, bymass, 17-22% of high-molecular-weight sodium hyaluronate, 8-12% of medium-molecular-weight sodium hyaluronate, 4.0-5.8% of low-molecular-weight sodium hyaluronate, 15-25% of propylene glycol, 35-46%of glycerol, 1.6-2.5% of PE9010 and 2.2-5.0% of sterile water. The stock solution for wrapping stem cell growth factors can effectively maintain and prolong the activity of active ingredients in lyophilized powder, and is simple to operate, high in fusion property, long in activity retention time and capable of prolonging the shelf life of final product when added into a biological skin care preparation in a later stage.

Description

technical field [0001] The invention relates to the technical field of biomaterials, in particular to a stock solution for encapsulating stem cell growth factors. Background technique [0002] Stem Cell Growth Factors is a high-efficiency protein and enzyme combination that stimulates the growth of autologous endogenous stem cells, and is also a combination of various cell growth factors that are essential for culturing stem cells in vitro. It is rich in epidermal growth factor (EGF ), fibroblast growth factor (FGF), nerve growth factor (NGF), hepatocyte growth factor (HGF), brain-derived neurotrophic factor (BDNF), platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF ), transforming growth factor (TGF) and other multiple active ingredients. In a clinical experiment conducted by Harvard University and Massachusetts Institute of Technology in the United States, 147 of 156 subjects showed significant differences from the control group, proving that ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/73A61K8/34A61Q19/00A61Q19/08
CPCA61Q19/00A61Q19/08A61K8/34A61K8/345A61K8/735
Inventor 王继明王坤王博迪高用慧
Owner 天津赛尔康生物医药科技有限公司