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Application of oxidized resveratrol

A technology for oxidizing resveratrol and liver fibrosis, applied in the fields of pharmacy and health food, can solve problems such as lack of research reports on the mechanism, and achieve the effects of wide sources, significant preventive effect, and reduced fibrosis damage degree.

Inactive Publication Date: 2018-11-16
新疆农业科学院农产品贮藏加工研究所
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there is a lack of relevant research reports on the role and mechanism of oxidized resveratrol, the main compound in mulberry, on acute liver injury in animals

Method used

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  • Application of oxidized resveratrol
  • Application of oxidized resveratrol
  • Application of oxidized resveratrol

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0021] Below in conjunction with specific embodiment the present invention will be further explained

[0022] 1. Grouping of experimental animals and induction of liver fibrosis

[0023] The female SD rats used in the experiment were purchased from the Experimental Animal Center of China Three Gorges University, license number: SCXK (E) 2011-0012.

[0024] Oxidized resveratrol was purchased from Nanjing Jingzhu Biotechnology Company, batch number 20160909.

[0025] The SD rats were randomly assigned to each breeding cage by 6 / cage, two cages constituted a group (that is, there were 12 mice in each group), and were divided into blank control group, CCl 4 Model group, 300mg / kg body weight silymarin treatment group, 100mg / kg body weight and 300mg / kg body weight oxidized resveratrol. After the SD rats were adapted to feeding for one week, the SD rats were given intraperitoneal injection of 40% CCl twice a week according to the amount of 0.1mL / 100g body weight. 4 , continuous in...

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Abstract

The invention discloses an application of oxidized resveratrol in preparation of medicines and health foods for preventing and treating acute liver injury and liver fibrosis. The oxidized resveratrolbelongs to a plant natural compound, has a wide range of sources and can be extracted and separated from various parts of mulberry. Compared with the CCl4 induction group, after oxidized resveratrol treatment according to ratios of 100 mg / kg and 300 mg / kg, the test group reduces the fibrotic damage degree of animal liver and observably reduces the expression levels of alpha-SMA, TGF-beta 1, p-SMADand p-ERK1 / 2 proteins. The test results show that the oxidized resveratrol has significant liver fibrosis prevention effects. The application can guide the development of novel methods for treating liver fibrosis and provides a novel direction and strategy for the development and utilization of mulberry.

Description

technical field [0001] The invention relates to the technical fields of pharmacy and health food, in particular to the application of oxidized resveratrol in preventing and treating acute liver injury and liver fibrosis. Background technique [0002] Hepatic fibrosis is a pathological change of chronic liver disease. The essence is that the synthesis and degradation of collagen-based extracellular matrix (ECM) loses dynamic balance. The increase in collagen synthesis and the relative decrease in degradation will lead to excessive ECM deposition in the liver. , causing liver fibrosis. At present, it is believed that the formation of liver fibrosis is caused by various liver-damaging factors that cause cell damage, necrosis, apoptosis and inflammation of liver tissue, and activate Kupffer cells to secrete a variety of cytokines. Together with cytokines, lipid peroxidation products and other chemical transmitters secreted by liver cells, platelets and sinus endothelial cells, ...

Claims

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Application Information

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IPC IPC(8): A61K31/05A61P1/16A23L33/10A61K36/605
CPCA23V2002/00A61K31/05A61K36/605A23L33/10A61P1/16A23V2200/30
Inventor 过利敏赵鑫孟伊娜张平李士明
Owner 新疆农业科学院农产品贮藏加工研究所
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