Tubular reaction synthetic method and apparatus for continuously producing acesulfame intermediate

A tubular reaction and synthesis device technology, applied in the preparation of amino compounds from amines, the preparation of sulfuric acid amide, organic chemistry, etc., can solve the problems of long synthesis reaction cycle, poor mass and heat transfer effect, low reaction conversion rate, etc., to achieve The effect of short reaction cycle, low production energy consumption and shortened operation time

Active Publication Date: 2018-11-16
东营市科维生物技术有限公司
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Problems solved by technology

At present, the same industry adopts batch-type kettle reaction, which has defects such as poor mass and heat transfer effect, low rea...

Method used

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  • Tubular reaction synthetic method and apparatus for continuously producing acesulfame intermediate

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preparation example Construction

[0022] On the other hand, the present invention proposes a tubular reaction synthesis method for continuous production of acesulfame potassium intermediate, comprising the steps of:

[0023] (1) Dichloromethane is first squeezed into the sulfamic acid mixing tank by a raw material delivery pump and stirred, then the sulfamic acid material bag is dropped into the sulfamic acid mixing tank by the screw propeller, Stir continuously for 0.4h-0.8h, then transfer the evenly stirred sulfamic acid solution into the first metering pump;

[0024](2) Open the jacket shallow cold circulating water valve of the synthesis tubular reactor, and control the temperature of the circulating water by a temperature controller to be 10°C to 15°C, then start the second metering pump and the first metering pump simultaneously pump, the sulfamic acid solution and triethylamine are simultaneously entered into the first pipeline mixer, and enter the synthesis tubular reactor through feed ports A and B re...

specific Embodiment

[0026] (1) Preparation of sulfamic acid solution

[0027] The raw material delivery pump in the tank area pumps methylene chloride into the sulfamic acid sulfamic acid mixing tank R-101A / B (the two are used alternately), starts stirring, and then lifts the flaky sulfamic acid package by the crane , the opening of the material bag is docked with the feeding port of the screw propeller M-101 and put into the sulfamic acid mixing tank at one time through the propeller. There is a special soft connection between the mouth of the sulfamic acid mixing tank and the outlet of the screw propeller. Sulfamic acid The sulphamic acid mixing tank is fully sealed, and the sulphamic acid is in the form of flakes, with a very small amount of dust. The sulfamic acid mixing tank continues to stir for 0.5h, and the uniformly stirred 19% sulfamic acid solution is transferred to the metering tank V-101 by the delivery pump P-101A / B. The organic waste gas volatilized by the sulfamic acid mixin...

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Abstract

The invention relates to tubular reaction synthetic method and apparatus for continuously producing acesulfame intermediate. The apparatus includes a sulfamic acid blending tank and a first metering pump, a spiral propeller, a synthetic tubular reactor, an acylation tubular reactor, a triethylamine metering tank and a second metering pump, a first tubular mixer, a second tubular mixer, an triethylamine sulfamate metering tank and a third metering pump, a diketene metering tank and a firth metering pump, a first heat insulation intermediate tank, and a second heat insulation intermediate tank.The tubular reaction synthetic apparatus is short in reaction period, allows continuous production and is low in production consumption, increases yield of the intermediate, reduces production cost and has competitiveness. The apparatus is high in automation degree and allows remote control, is safe and reliable and can increase productivity and efficiency.

Description

technical field [0001] The invention relates to a tubular reaction synthesis method and device for continuously producing acesulfame potassium intermediates. Background technique [0002] Acesulfame K is a safe and economical sugar-free sweetener. It has good taste, good synergy, does not participate in the physiological metabolism in the human body, and does not accumulate. It is widely used in daily chemicals, food, beverages, and medicine. manufacturing etc. [0003] At present, there are four synthetic methods of acesulfame potassium: (1) aminosulfophthalein fluoride--diketene method; (2) acetoacetamide--sulfur trioxide method; (3) acetoacetamide--fluorosulfuryl fluoride method ; (4) diketene - sulfur trioxide method. Acetoacetamide--fluorine sulfuryl fluoride method is highly corrosive and causes serious environmental pollution; aminosulfonyl phthalofluoride--diketene method and acetoacetamide--sulfur trioxide method have little industrial value and high cost; diketen...

Claims

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Application Information

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IPC IPC(8): C07C307/02C07C303/34C07C209/68C07C211/05
CPCC07C209/68C07C303/34C07C307/02C07C211/05
Inventor 张照明
Owner 东营市科维生物技术有限公司
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