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Chitosan hydrogel and preparation method thereof

A technology of chitosan and chitosan solution, which is applied in pharmaceutical formulations, medical science, bandages and other directions to achieve the effects of shortening coagulation time, simple and convenient preparation method and good biodegradability

Inactive Publication Date: 2018-11-20
HUNAN GUOSHENG GRAPHITE TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The technical problem to be solved by the present invention is to overcome the defects and insufficiencies of the above-mentioned prior art, aiming at skin wounds caused by trauma, burns, scalds, operations, etc. and other problems, providing a chitosan hydrogel with low toxic and side effects and capable of effectively inhibiting scar formation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The preparation of embodiment 1 chitosan hydrogel

[0025] (1) This example provides a chitosan hydrogel, which is prepared from chitosan, graphene oxide, and scutellarin. The dosage of each component is: chitosan (10KDa) 3g, graphene oxide ( 3KDa) 0.5g, scutellarin 1.5g.

[0026] (2) Preparation method

[0027] According to the above quality, the raw materials of each component are respectively selected for use, and the scutellarin / chitosan composite hydrogel is prepared. The specific method includes the following steps:

[0028] S1. dissolving chitosan in acetic acid solution to obtain chitosan acetic acid solution; adding graphene oxide to chitosan acetic acid solution and mixing to obtain chitosan / graphene oxide mixed solution;

[0029] S2. adding the breviscapine powder into the chitosan / graphene oxide mixed solution, stirring and mixing evenly, and defoaming to obtain the breviscapine / chitosan solution;

[0030] S3. After the additive is configured into a corre...

Embodiment 2

[0031] The preparation of embodiment 2 chitosan hydrogel

[0032] This example provides a chitosan hydrogel for inhibiting scar formation, which is prepared from chitosan, graphene oxide, and breviscapine, and the dosage of each component is: chitosan (20KDa) 5g, graphene oxide (8KDa) 0.8g, scutellarin 1.8g.

[0033] For the specific preparation method, refer to Example 1, which will not be repeated here.

Embodiment 3

[0034] The preparation of embodiment 3 chitosan hydrogels

[0035] This example provides a chitosan hydrogel for inhibiting scar formation, which is prepared from chitosan, graphene oxide, and breviscapine, and the dosage of each component is: chitosan (100KDa) 4g, graphene oxide (5KDa) 0.7g, scutellarin 1.6g.

[0036] For the specific preparation method, refer to Example 1, which will not be repeated here.

[0037] The hydrogel provided by the invention can accelerate the healing of wounds through the effective combination of breviscapine, chitosan and graphene oxide, has the characteristics of hemostasis, antibacterial and inhibits scar formation from the root, can shorten the coagulation time, Accelerates wound healing and reduces scar formation. The preparation method of the hydrogel is simple and convenient, and has strong practicability. The polymer materials used are all non-toxic and biodegradable materials, and the composite hydrogel produced has good biocompatibili...

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Abstract

The invention belongs to the technical field of biomaterials and in particular relates to chitosan hydrogel and a preparation method thereof. The chitosan hydrogel is prepared from breviscapine, chitosan and graphene oxide in a mass ratio of (1 to 2):(3 to 5):(0.5-1) in a compounding manner. The chitosan hydrogel can accelerate the wound healing by effective combining of breviscapine, chitosan andgraphene oxide, and has the advantages of hemostasis, bacteriostasis, and fundamental root-cause inhibition of scar formation, thus shortening the coagulation time, accelerating the wound healing, and reducing the scar formation. The preparation method of the chitosan hydrogel is simple, convenient, fast and high in practicability; and polymer materials used are non-toxic and biodegradable material, so that the obtained composite hydrogel has the advantages of high biocompatibility, excellent biodegradability, high absorption performance, safety and non-toxicity and has the good application prospect.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials. More specifically, it relates to a chitosan hydrogel and a preparation method thereof. Background technique [0002] Scar is the disorder of fibroblast proliferation in the skin dermis, resulting in excessive production of fibroblasts and excessive deposition of collagen. It is a common complication after skin trauma and surgery, and seriously affects the appearance and psychology of patients. The pathogenesis of scar and its prevention and treatment methods have always been a research hotspot in the medical field, and there is no clear conclusion on its pathogenesis. Scar is the product of skin wound repair and healing process. Except for superficial wounds that can be repaired by simple epithelial formation, any damage that reaches deep into the dermis and subcutaneous tissue will be repaired by scar formation. Theoretically speaking, once the scar is formed, even if the most del...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08L5/08C08K5/1545C08K3/04A61L26/00
CPCC08J3/075A61L26/0004A61L26/0023A61L26/0066A61L26/008A61L26/009A61L2300/232A61L2300/40A61L2300/404A61L2400/04C08J2305/08C08K3/042C08K5/1545C08L5/08
Inventor 林前锋
Owner HUNAN GUOSHENG GRAPHITE TECH CO LTD