Method for rapidly eliminating bacterial biofilm on surface of bone implant by utilizing near infrared light

A technology for implants and red phosphorus films, which can be used in coatings, medical science, surgery, etc. It can solve the problems that the photothermal properties of red phosphorus have not been reported, and achieve excellent biocompatibility and osteogenic performance. Antimicrobial strategy, effect of promoting osseointegration

Active Publication Date: 2018-11-23
HUBEI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the photothermal properties associated w

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  • Method for rapidly eliminating bacterial biofilm on surface of bone implant by utilizing near infrared light
  • Method for rapidly eliminating bacterial biofilm on surface of bone implant by utilizing near infrared light
  • Method for rapidly eliminating bacterial biofilm on surface of bone implant by utilizing near infrared light

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preparation example Construction

[0056] The second aspect of the present invention provides a method for preparing the above-mentioned red phosphorus modified titanium implant, the steps comprising:

[0057] S1. Titanium surface pretreatment: polish the pure titanium surface to be smooth, and dry it after ultrasonic cleaning;

[0058] S2. Ti-RP preparation: place the titanium obtained in step S1 on the amorphous red phosphorus powder from which the surface oxide layer has been removed, raise the temperature to 640-660° C. under an inert gas atmosphere with a pressure of 0.02-0.04 MPa, keep the temperature for 4-6 hours, and then Cool down to 340-360°C, keep warm for 1.5-2.5h, and obtain Ti-RP after cooling;

[0059] S3. Preparation of Ti-RP-IR780-RGDC: Add the dichloromethane solution containing IR780 dropwise to the surface of Ti-RP, and dry it in vacuum to obtain Ti-RP-IR780. Put Ti-RP-IR780 in Tris-HCl containing dopamine After soaking in the buffer solution, soak in the RGDC aqueous solution, wash with w...

Embodiment 1

[0072] This embodiment provides a red phosphorus modified titanium implant. The implant is a titanium sheet with red phosphorus deposited on the surface. The red phosphorus is deposited on the titanium surface to form a red phosphorus film. The thickness of the red phosphorus mold is 1.2 μm, the red phosphorus crystal is polygonal, the red phosphorus crystal phase is a fiber phase, the near-infrared photosensitizer IR780 is electrostatically adsorbed on the red phosphorus film, and a polydopamine film is attached to the red phosphorus film adsorbed with IR780, The polydopamine membrane is bound to the RGDC polypeptide through a chemical bond.

[0073] The preparation method of the above-mentioned red phosphorus modified titanium implant includes the following steps: Step 1, surface pretreatment of the titanium sheet: medical pure titanium with a diameter of 6 mm and a thickness of 2 mm was selected for the experiment. The surface of pure titanium is mechanically polished with ...

Embodiment 2

[0092] This embodiment provides a red phosphorus modified titanium implant. The implant is a titanium sheet with red phosphorus deposited on the surface. The red phosphorus is deposited on the titanium surface to form a red phosphorus film. The thickness of the red phosphorus mold is 1.4 μm, the red phosphorus crystal is polygonal, the red phosphorus crystal phase is a fiber phase, the near-infrared photosensitizer IR780 is electrostatically adsorbed on the red phosphorus film, and a polydopamine film is attached to the red phosphorus film adsorbed with IR780, The polydopamine membrane is bound to the RGDC polypeptide through a chemical bond.

[0093] The preparation method of the above-mentioned red phosphorus modified titanium implant comprises the following steps:

[0094] Step 1, surface pretreatment of the titanium sheet: medical pure titanium with a diameter of 6 mm and a thickness of 2 mm was selected for the experiment. The surface of pure titanium is mechanically pol...

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Abstract

The invention relates to a red phosphorus modified titanium implant and a preparation method thereof, and further provides a method for rapidly eliminating a bacterial biofilm on the surface of a boneimplant by utilizing near infrared light. The method comprises the following steps of 1, carrying out surface pretreatment on a titanium sheet; 2, preparing a red phosphorus film on the surface of the titanium sheet so as to obtain Ti-RP; and 3, modifying the surface of the Ti-RP with IR780 and RGDC polypeptide so as to obtain Ti-RP-IR780-RGDC. The method has the advantages that 1, the titanium implant is simultaneously endowed with the surface photo-thermal and photocatalytic properties, so that heat and active oxygen can be generated under near-infrared illumination; and 2, a novel non-surgical and noninvasive treatment method for biofilm infection on the surface of the in-vivo implant is provided, and meanwhile, the implant is endowed with excellent biocompatibility and osteogenic performance.

Description

technical field [0001] The invention relates to the technical field of biofilm elimination on the surface of medical devices, in particular to a method for quickly eliminating bacterial biofilm on the surface of bone implants based on red phosphorus modified titanium implants by using near infrared. Background technique [0002] Surface photothermal photodynamic research of medical titanium alloy is a frontier research topic in the field of medical metal materials. [0003] Although metal materials represented by titanium alloys are widely used in hard tissue systems such as oral cavity and orthopedic surgery as artificial implants and orthopedics, early metal implant operations generally fail because of the damage to the surface and physiology of metal implants. The interaction between environments lacks theoretical cognition and corresponding treatment measures are not adopted. The surface of domestic implanted medical devices such as medical titanium alloy and stainless ...

Claims

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Application Information

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IPC IPC(8): A61L31/02A61L31/08A61L31/10A61L31/16A61L31/14
CPCA61L31/028A61L31/08A61L31/088A61L31/10A61L31/14A61L31/16A61L2300/112A61L2300/216A61L2300/404A61L2420/06A61L2420/08C08L89/00
Inventor 吴水林谭磊刘想梅李浚
Owner HUBEI UNIV
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