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Preparation method of paper microfluidic chip

A microfluidic chip and paper-based technology, applied to chemical instruments and methods, laboratory containers, laboratory utensils, etc., to achieve the effects of preventing seepage, simple operation, and low cost

Active Publication Date: 2018-11-23
NORTHEASTERN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

For these reasons, the target users of paper microfluidic chips are developing countries and some impoverished areas with poor conditions. A low-cost, high-sensitivity, high-throughput analysis and detection instrument, therefore, a method for preparing a paper microfluidic chip is needed to solve this problem

Method used

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  • Preparation method of paper microfluidic chip

Examples

Experimental program
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Effect test

Embodiment 1

[0027] Such as figure 1 As shown, a method for preparing a paper microfluidic chip comprises the following steps:

[0028] S100, preparing a pattern template by processing a pattern with a microfluidic channel on the template;

[0029] S200, coating the liquid barrier agent in the pattern, so that a barrier agent stamp with a pattern is formed on the pattern template;

[0030] S300, attaching the analysis paper to the seal of the barrier agent, so that the barrier agent penetrates into the front and back sides of the analysis paper at the same position;

[0031] S400. Heating or UV irradiating the analysis paper with the barrier agent infiltrated on the front and back sides, so that the barrier agent is cured in the analysis paper to form a paper microfluidic chip.

[0032] The preparation method provided by the present invention can prepare a template with a microfluidic channel pattern by simply folding the template 1, and by using the pattern template to simultaneously im...

Embodiment 2

[0044] Referring to Example 1, the difference in the preparation method of a paper microfluidic chip provided in this example is that when a pattern with a microfluidic channel is processed on the template to prepare a pattern template, processing After producing at least two mirrored patterns with microfluidic channels, the adjacent templates are folded at the axis of symmetry between the two patterns, so that the adjacent patterns with microfluidic channels are folded The positions on the two template papers are the same, wherein the axis of symmetry between the two patterns is the turned side of the folded template.

Embodiment 3

[0046] Referring to Example 1, the difference in the preparation method of a paper-based microfluidic chip provided in this example is that when heating the analysis paper with barrier agents on both sides, the analysis paper is heated at 100°C. Heating at low temperature for 5 minutes to solidify the barrier agent infiltrated into the analysis paper to form a paper microfluidic chip.

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Abstract

The invention discloses a preparation method of a paper microfluidic chip. The preparation method comprises the following steps: preparing a pattern template by processing a pattern with a microfluidic channel on a template; coating the inside of the pattern with a liquid blocking agent in order to form a blocking agent stamp with the pattern on the pattern template; laminating chromatography paper and the blocking agent stamp in order to make the blocking agent permeate into the front side and the back side of the chromatography paper at the same position; performing heating or UV (Ultraviolet) radiation on the chromatography paper with the blocking agent permeating into the front side and the back side to cure the blocking agent in the chromatography paper so as to form the paper microfluidic chip. The preparation method provided by the invention is easy to operate, can meet the requirement of forming the paper microfluidic channel by only cutting the pattern template without the need of any instrument equipment, the obtained microfluidic channel effectively prevents liquid permeation, and an efficient, low-cost and practical method is provided for the preparation of the paper microfluidic chip.

Description

technical field [0001] The invention belongs to the field of chip technology, and in particular relates to a preparation method of a paper microfluidic chip. Background technique [0002] Microfluidics is a scientific technology that uses microchannels to precisely manipulate and control microscale fluids. It can achieve high sensitivity, high specificity, high throughput, and low-cost detection of analytes. After it was first proposed in the early 1990s, it is considered to have great development potential and broad application prospects in biomedical research. [0003] Paper-based Microfluidics is a branch of microfluidics. In 2007, the Whitesides group at Harvard University first proposed the concept of paper microfluidics. The group introduced a photolithographic pattern filter paper for colorimetric analysis of urine pH and protein. Different from traditional silicon-based or polymer microfluidic chips, paper-based microfluidics has the advantages of good biocompatibi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01L3/00
CPCB01L3/502707B01L2300/126B01L2300/161
Inventor 谢丽萍曾何德乐钱唯
Owner NORTHEASTERN UNIV
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