Titanium alloy nano-coating with antibacterial function and preparation method thereof

A nano-coating, titanium alloy technology, applied in metal material coating process, coating, ion implantation plating, etc., can solve the problems of heavy economic and mental burden of patients, aggravation of antibiotics, rampant resistance of bacteria, etc. Effects of improved surface roughness, reduced emission of large particles, and improved film density

Active Publication Date: 2018-11-23
INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Bacterial infections from medical devices can have disastrous consequences for patients when they occur
Patients need to undergo another 1-2 operations to remove the implanted medical device and remove the lesion, which will bring heavy economic and mental burden to the patient, and will also have a certain negative impact on the hospital and society.
Moreover, the use of antibiotics in medical drugs is increasing day by day, and the abuse of antibacterial drugs will lead to the spread of drug-resistant bacteria. Once extensive drug resistance occurs, even in routine operations such as caesarean section and hip replacement, patients will die from the risk of surgery complicated by infection will multiply

Method used

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  • Titanium alloy nano-coating with antibacterial function and preparation method thereof
  • Titanium alloy nano-coating with antibacterial function and preparation method thereof
  • Titanium alloy nano-coating with antibacterial function and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-5

[0019] TiCuCe layer plating: using arc ion plating technology, the target material is a titanium copper cerium alloy target, the copper content in the targets of Examples 1-5 are: 2%, 4%, 6%, 8%, 10% (mass percentage ); The cerium content is in order: 0.05%, 0.06%, 0.07%, 0.08%, 0.09% (mass percentage).

[0020] The substrate is made of pure medical titanium (brand name TA1ELI), the sample size is 15mm×15mm×5mm, and the size of the coating surface is 15mm×15mm. Before coating, the sample surface is ground, polished, ultrasonically cleaned and dried, and then placed on the sample stage of the vacuum chamber until the vacuum degree in the vacuum chamber reaches 6×10 -3 At Pa, the vacuum chamber is heated to 400°C, argon is introduced into the vacuum chamber, the gas flow is set to 80sccm, the pressure is controlled at 0.7Pa, the substrate is pulsed with a negative bias voltage of -800V, and the sample is subjected to glow cleaning for 10 minutes; Then, adjust the flow of argon gas ...

Embodiment 6-10

[0023] TiCuCe layer plating: using arc ion plating technology, the target material is a titanium copper cerium alloy target, the copper content in the targets of Examples 6-10 are: 2%, 4%, 6%, 8%, 10% (mass percentage ); The cerium content is in order: 0.05%, 0.06%, 0.07%, 0.08%, 0.09% (mass percentage).

[0024] The base material is a medical titanium alloy (brand name TC4), the sample size is 15mm×15mm×5mm, and the size of the coating surface is 15mm×15mm. Before coating, the sample surface is ground, polished, ultrasonically cleaned and dried, and then placed on the sample stage of the vacuum chamber until the vacuum degree in the vacuum chamber reaches 8×10 -3 At Pa, the vacuum chamber is heated to 500°C, argon gas is introduced into the vacuum chamber, the gas flow is set to 90sccm, the pressure is controlled at 0.8Pa, the substrate is pulsed negative bias -900V, and the sample is subjected to glow cleaning for 10 minutes; Then, adjust the flow of argon gas to adjust the pre...

Embodiment 11-15

[0027] TiCuCe layer plating: using arc ion plating technology, the target material is a titanium copper cerium alloy target, in the target material of Examples 11-15. The copper content is: 2%, 4%, 6%, 8%, 10% (mass percentage); the cerium content is: 0.05%, 0.06%, 0.07%, 0.08%, 0.09% (mass percentage).

[0028] The base material is made of medical stainless steel (brand name is 316L), the sample size is 15mm×15mm×5mm, and the size of the coating surface is 15mm×15mm. Before coating, the sample surface is ground, polished, ultrasonically cleaned and dried, and then placed on the sample stage of the vacuum chamber until the vacuum degree in the vacuum chamber reaches 1×10 -2 At Pa, the vacuum chamber is heated to 400°C, argon gas is introduced into the vacuum chamber, the gas flow is set to 60sccm, the pressure is controlled at 0.5Pa, the substrate is pulsed negative bias -600V, and the sample is subjected to glow cleaning for 10 minutes; Then, adjust the flow of argon gas to adju...

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Abstract

The invention aims to provide a titanium alloy nano-coating with an antibacterial function and a preparation method thereof. The titanium alloy nano-coating is characterized by comprising the following chemical components of, by mass percent, 2-10% of Cu, 0.04-0.1% of Ce and the balance Ti, wherein the preferable range of the chemical components reaches the following standards that the Cu accountsfor 4-8%, the Ce accounts for 0.06-0.08%, and the balance is the Ti. According to the preparation method of the titanium alloy nano-coating, a titanium-copper-cerium nano-coating with the antibacterial function is formed on the surface of a substrate, so that the substrate can obtain a coating with the broad spectrum and the antibacterial function; and the coating has the excellent corrosion resistance in a biological medium and a corrosive solution.

Description

Technical field [0001] The invention belongs to the technical field of depositing medical nano-coatings on the surface of metal materials, and specifically provides a titanium alloy nano-coating with antibacterial function and a preparation method thereof. Background technique [0002] In the current medical field, the problem of bacterial infection caused by metal medical device implants has become more and more important. According to statistics, the annual incidence of orthopedic implant-related infections in the United States has reached about 4.3%. The relevant data in the "Practical Handbook for Prevention and Control of Nosocomial Infections" issued by the World Health Organization (WHO) shows that more than 14 million people worldwide suffer from nosocomial infections every day, and 60% of bacterial infections are related to the medical devices used. Bacterial infections caused by medical devices will have catastrophic consequences for patients once they occur. The pati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C23C14/32C23C14/14C22C14/00
CPCC22C14/00C23C14/14C23C14/325
Inventor 任玲彭聪杨柯赵彦辉
Owner INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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