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Nano drug for precise targeted tumor treatment and preparation method thereof

A targeted therapy and nanotechnology, applied in the medical field, can solve problems such as unclear direction and can not completely overcome drug resistance, and achieve the effect of stable drug carrying, biocompatibility and good penetration.

Inactive Publication Date: 2018-11-27
CHENDU NEW KELI CHEM SCI CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0008] It can be seen that the doxorubicin drugs used in the prior art for targeted treatment of tumors mainly treat cancer through loading, but due to unclear direction, they always focus on the chemotherapeutic effect of chemotherapy drugs and cannot completely overcome drug resistance In order to better penetrate the lysosomal membrane and act on cells and improve the targeted therapeutic effect of doxorubicin drugs, in-depth research on the carrier is needed

Method used

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  • Nano drug for precise targeted tumor treatment and preparation method thereof

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Effect test

Embodiment 1

[0031] a. Add doxorubicin drugs, silica airgel and chitosan into water, stir and disperse to make a colloidal liquid;

[0032] b, add AB type cyclic phosphate monomer to the colloid liquid that step a makes, heat up and carry out bulk polymerization, generate hyperbranched polyphosphate, and embed adriamycin drugs in the branched cavity;

[0033] c. Disperse the doxorubicin-loaded hyperbranched polyphosphate prepared in step b in ethanol, use acetone to precipitate, wash, and then vacuum-dry to prepare nano-drugs for precise targeted therapy of tumors.

[0034] In step a, the porosity of the silica airgel is 98%;

[0035] In step a, 35 parts by weight of doxorubicin, 12 parts by weight of silica airgel, 10 parts by weight of chitosan, and 43 parts by weight of water; in step c, 25 parts by weight of hyperbranched polyphosphate, 75 parts by weight of ethanol ; In step b, 40 parts by weight of colloid liquid, 60 parts by weight of AB type cyclic phosphate ester monomer;

[003...

Embodiment 2

[0038] a. Add doxorubicin drugs, silica airgel and chitosan into water, stir and disperse to make a colloidal liquid;

[0039] b, add AB type cyclic phosphate monomer to the colloid liquid that step a makes, heat up and carry out bulk polymerization, generate hyperbranched polyphosphate, and embed adriamycin drugs in the branched cavity;

[0040]c. Disperse the doxorubicin-loaded hyperbranched polyphosphate prepared in step b in ethanol, use acetone to precipitate, wash, and then vacuum-dry to prepare nano-drugs for precise targeted therapy of tumors.

[0041] In step a, the porosity of the silica airgel is 95%;

[0042] In step a, 30 parts by weight of doxorubicin, 10 parts by weight of silica airgel, 8 parts by weight of chitosan, and 52 parts by weight of water; in step c, 20 parts by weight of hyperbranched polyphosphate, 80 parts by weight of ethanol ; In step b, 30 parts by weight of colloidal liquid and 70 parts by weight of AB-type cyclic phosphate monomer;

[0043] ...

Embodiment 3

[0045] a. Add doxorubicin drugs, silica airgel and chitosan into water, stir and disperse to make a colloidal liquid;

[0046] b, add AB type cyclic phosphate monomer to the colloid liquid that step a makes, heat up and carry out bulk polymerization, generate hyperbranched polyphosphate, and embed adriamycin drugs in the branched cavity;

[0047] c. Disperse the doxorubicin-loaded hyperbranched polyphosphate prepared in step b in ethanol, use acetone to precipitate, wash, and then vacuum-dry to prepare nano-drugs for precise targeted therapy of tumors.

[0048] In step a, the porosity of the silica airgel is 99%;

[0049] In step a, 40 parts by weight of doxorubicin, 15 parts by weight of silica airgel, 12 parts by weight of chitosan, and 33 parts by weight of water; in step c, 30 parts by weight of hyperbranched polyphosphate, 70 parts by weight of ethanol ; In step b, 50 parts by weight of colloidal liquid and 50 parts by weight of AB-type cyclic phosphate monomer;

[0050...

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Abstract

The invention disclose a nano drug for precise targeted tumor treatment and a preparation method thereof. The preparation method includes the steps of a, adding a doxorubicin drug, silicon dioxide aerogel and chitosan into water to prepare a colloidal solution; b, adding AB type cyclic phosphate monomers, and heating to generate hyperbranched polyphosphate loading the doxorubicin drug; c, dispersing into ethanol, and performing precipitation washing and vacuum drying to obtain the nano drug for precise targeted tumor treatment. The preparation method has the advantages that the prepared targeted drug is stable in drug carrying, clear and definite in targeting performance, good in penetrability to a lysosome membrane, capable of killing cancer cells in a targeted manner, good in biocompatibility and biodegradability, capable of effectively overcoming the drug resistance of the cancer cells and evident in curative effect on breast cancer, osteosarcoma, bladder cancer and liver cancer.

Description

technical field [0001] The invention relates to the medical field, in particular to the preparation of targeted drugs, in particular to a nano-drug for precise targeted therapy of tumors and a preparation method thereof. Background technique [0002] In recent years, cancer is a disease that seriously affects human health. Chemotherapy is the main method for treating tumors. However, chemotherapy has serious adverse reactions. At the same time, traditional anticancer drugs attack normal cells while killing tumor cells, and the side effects are extremely severe. How to release anticancer drugs only in tumor tissue without affecting normal cells is an urgent problem to be solved. At present, precision medicine has become the first choice for the treatment of tumors. Targeted therapy has achieved obvious results in the treatment of certain types of cancer since the late 1990s. It can treat cancer as effectively as chemotherapy, but its side effects are much less than chemothera...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K31/704A61K47/34A61P35/00
CPCA61K31/704A61K9/146A61K47/34A61P35/00
Inventor 陈庆曾军堂
Owner CHENDU NEW KELI CHEM SCI CO LTD
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