Preparation method of zinc-containing antibacterial gel

A technology of gel and zinc compound is applied in the field of preparation of zinc-containing antibacterial gel, and achieves the effects of good colloidal stability, no change in antibacterial properties, and high thermal and chemical stability

Active Publication Date: 2018-11-27
XIAN HUIPU BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The antibacterial gel made of zinc as a single factor has no application in the field of gynecological sterilization and anti-inflammation and dermatology.

Method used

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  • Preparation method of zinc-containing antibacterial gel
  • Preparation method of zinc-containing antibacterial gel
  • Preparation method of zinc-containing antibacterial gel

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preparation example Construction

[0021] Zinc is a kind of inorganic antibacterial element, because its security is good, bactericidal spectrum, photothermal stability are good etc. many advantages, the gel that the present invention develops is the antibacterial gel of main component with zinc oxide, (zinc oxide is antibacterial to Both Gram-negative and Gram-positive bacteria have strong antibacterial activity). A preparation method for zinc-containing antibacterial gel, comprising the following steps:

[0022] Step 1: select a zinc-containing compound and white carbon black in a certain weight ratio, mix them uniformly, calcinate at high temperature for 2 hours, and sieve after cooling to obtain Si-Zn powder. Among them, the weight ratio of zinc-containing compounds to white carbon black is controlled at (7-25):10, and zinc-containing compounds include Zn-(CH3COO)2, Zn-(CH3COO)2·2H2O, ZnSO4, ZnSO4·6H2O, ZnSO4· One or any combination of 7H2O, ZnO, ZnCO3ZnCl2, Zn(OH)2 Zn(NO3)2·6H2O to obtain Si-Zn powder wit...

Embodiment 1

[0031] A preparation method of zinc-containing antibacterial gel:

[0032] Step 1, the preparation of Si-Zn powder, weigh 68 grams of Zn(CH3COO)2 2H2O, 32 grams of white carbon black (SiO2), after fully mixing, calcining at a high temperature of 500 ° C for 2 hours, after natural cooling, the powder over 200 mesh / inch 2 Sieve and mix to obtain Si-Zn powder, measure the zinc content (about 35%), and determine the consumption of Si-Zn powder when preparing the gel.

[0033] Step 2, the preparation of zinc-containing antibacterial gel, take carbomer 8.5g, purified water 483g, 15% KOH 8.5g, 50% PEG50g, menthyl lactate 1g, propylene glycol 20g, Si-Zn powder 12g, mix and homogenize treatment to obtain zinc-containing antibacterial gel. The prepared zinc-containing antibacterial gel contains 0.62% of zinc, 1.45% of carbomer, 0.17% of menthyl lactate, 3.4% of propylene glycol and 4.3% of PEG. Adding PEG can also enhance the fineness and stability of the colloid.

Embodiment 2

[0035] A preparation method of zinc-containing antibacterial gel:

[0036] Step 1, the preparation of Si-Zn powder, weigh zinc oxide (ZnO) 250g, white carbon black (SiO 2 ) 320g, after fully mixing, calcined at high temperature 500°C for 2 hours, after natural cooling, the powder is over 200 mesh / inch 2 Sieve and mix to obtain Si-Zn powder, and determine the zinc content (about 36%).

[0037] Step 2, the preparation of zinc-containing antibacterial gel, take carbomer 1.45g, purified water 74.2g, 15% KOH 1.4g, Si-Zn powder 2.9g, menthyl lactate 0.1g, propylene glycol 5g, glycerol 15g, Homogeneous treatment after mixing to obtain zinc-containing antibacterial gel. Adding glycerol can also improve colloid fusion performance.

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Abstract

The invention discloses a preparation method of zinc-containing antibacterial gel. The preparation method of the zinc-containing antibacterial gel comprises the following steps: step 1, selecting a zinc-containing compound and white carbon black at a certain weight ratio, uniformly mixing and then calcining for 2 hours at high temperature, cooling and then sieving to obtain Si-Zn powder; step 2, mixing carbomer, purified water, KOH, menthyl lactate, propanediol and Si-Zn powder in proportion, and homogenizing to obtain the zinc-containing antibacterial gel. The Si-Zn compound which is calcinedat high temperature is a zinc-containing antibacterial gel with single antibacterial factors, and the prepared antibacterial gel has the following characteristics of inorganic antibacterial agent: sterilization spectrum, heat resistance, safety, durability, zero drug resistance and the like, and has specific non-toxicity, non-migration and abilities of absorbing and scattering ultraviolet rays ofzinc oxide, the antibacterial gel is good in stability after being stored at the temperature of 54 DEG C and being illuminated by sunlight for two months, the antibacterial performance does not change, and thermal stability and chemical stability are high.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a preparation method of zinc-containing antibacterial gel. Background technique [0002] Zinc, silver, and copper are all inorganic antibacterial agents, which have the advantages of bactericidal spectrum, high efficiency, heat resistance, safety, durability, and no drug resistance. They have been widely valued and used in medical treatment, daily chemicals, coatings, Textile finishing, plastics and other fields. Zinc and its compounds have high thermal and chemical stability, and have the ability to absorb and scatter ultraviolet radiation. About the antibacterial mechanism of zinc and its compound, its saying is a lot, generally agrees at present, has the following several viewpoints: 1. the catalysis of light can produce active oxygen (·O 2 - ,·OH, 1 o 2 ) It can oxidize with most organic matter, thereby killing or inhibiting the growth and reproduct...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/30A61K9/06A61K47/32A61P31/02A61P31/04A61P17/00
CPCA61K9/0014A61K9/06A61K33/30A61K47/32A61P15/00A61P17/00A61P31/02A61P31/04
Inventor 吴晓军
Owner XIAN HUIPU BIOTECH CO LTD
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