Bacteriostatic type ultrasonic coupling agent as well as preparation method and application thereof
An ultrasonic coupling agent and solution technology, applied in echo/ultrasonic imaging agents, medical preparations containing active ingredients, topical antibacterial agents, etc. The effect of good dispersion effect and simple preparation method
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[0032] Preparation of transparent hydrogel:
[0033] The swollen carbomer 940 solution is used as the main component of the hydrogel, glycerin and polyethylene glycol 400 are added as regulators, and a transparent hydrogel is formed after the reaction as a skeleton. The specific steps are as follows:
[0034] Take 7.2g of Carbomer 940, put it into 300ml of deionized water and stir, fully swell the Carbomer after 2 days and seal it for storage; take 40ml of Carbomer, add 10ml of water to slightly dilute and stir evenly, and prepare 5g of glycerin, 2g of polyethylene glycol Glycol 400, 0.3g Tween stir to dissolve, dissolve well, pour into carbomer and stir, add 150ml deionized water to dilute to 200ml, put into vacuum box after stirring, vacuumize for half an hour to remove bubbles in the solution, and dissolve the solution The stirring method was changed to mechanical stirring, and triethanolamine was slowly added dropwise using a dropper, the solution system gradually thickene...
Embodiment 1
[0036] Transparent hydrogel mixed with 3% lauryldimethylammonium chloride solution as an antimicrobial agent:
[0037] Take 7.2g of Carbomer 940, put it into 300ml of deionized water and stir, fully swell the Carbomer after 2 days and seal it for storage; take 40ml of Carbomer, add 10ml of water to slightly dilute and stir evenly, prepare 5g of glycerin, polyethylene glycol Stir and dissolve 2g alcohol and 0.3g Tween, pour into carbomer and stir after dissolving, add 0.5ml of 3% dodecyldimethylammonium chloride solution, dilute to 200ml with 150ml deionized water, put Into the vacuum box, vacuum half an hour to remove the bubbles in the solution. Change the stirring method of the solution to mechanical stirring, slowly add triethanolamine dropwise with a dropper, the solution system will gradually thicken, and control the dropping speed so as not to make the gel too viscous.
Embodiment 2
[0039] Similar to Example 1, only transparent hydrogel is mixed with 3% lauryl dimethyl ammonium chloride solution as the antibacterial agent, and the antibacterial agent mixing ratio is different:
[0040]Take 7.2g of Carbomer 940, put it into 300ml of deionized water and stir, fully swell the Carbomer after 2 days and seal it for storage; take 40ml of Carbomer, add 10ml of water to slightly dilute and stir evenly, prepare 5g of glycerin, polyethylene glycol Alcohol 2g, Tween 0.3g, stirred and dissolved, dissolved well, poured into carbomer and stirred, added 1ml of 3% lauryl dimethyl ammonium chloride solution, added 150ml of deionized water to dilute to 200ml, put in Vacuum box, vacuum for half an hour to remove air bubbles in the solution. Change the stirring method of the solution to mechanical stirring, slowly add triethanolamine dropwise with a dropper, the solution system will gradually thicken, and control the dropping speed so as not to make the gel too viscous.
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