Bacteriostatic type ultrasonic coupling agent as well as preparation method and application thereof

An ultrasonic coupling agent and solution technology, applied in echo/ultrasonic imaging agents, medical preparations containing active ingredients, topical antibacterial agents, etc. The effect of good dispersion effect and simple preparation method

Inactive Publication Date: 2018-12-07
SHANGHAI NAT ENG RES CENT FORNANOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the problem that the existing ultrasonic coupling agent has a large sound attenuation coefficient and no antibacterial performance, the purpose of the present invention

Method used

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  • Bacteriostatic type ultrasonic coupling agent as well as preparation method and application thereof
  • Bacteriostatic type ultrasonic coupling agent as well as preparation method and application thereof
  • Bacteriostatic type ultrasonic coupling agent as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0032] Preparation of transparent hydrogel:

[0033] The swollen carbomer 940 solution is used as the main component of the hydrogel, glycerin and polyethylene glycol 400 are added as regulators, and a transparent hydrogel is formed after the reaction as a skeleton. The specific steps are as follows:

[0034] Take 7.2g of Carbomer 940, put it into 300ml of deionized water and stir, fully swell the Carbomer after 2 days and seal it for storage; take 40ml of Carbomer, add 10ml of water to slightly dilute and stir evenly, and prepare 5g of glycerin, 2g of polyethylene glycol Glycol 400, 0.3g Tween stir to dissolve, dissolve well, pour into carbomer and stir, add 150ml deionized water to dilute to 200ml, put into vacuum box after stirring, vacuumize for half an hour to remove bubbles in the solution, and dissolve the solution The stirring method was changed to mechanical stirring, and triethanolamine was slowly added dropwise using a dropper, the solution system gradually thickene...

Embodiment 1

[0036] Transparent hydrogel mixed with 3% lauryldimethylammonium chloride solution as an antimicrobial agent:

[0037] Take 7.2g of Carbomer 940, put it into 300ml of deionized water and stir, fully swell the Carbomer after 2 days and seal it for storage; take 40ml of Carbomer, add 10ml of water to slightly dilute and stir evenly, prepare 5g of glycerin, polyethylene glycol Stir and dissolve 2g alcohol and 0.3g Tween, pour into carbomer and stir after dissolving, add 0.5ml of 3% dodecyldimethylammonium chloride solution, dilute to 200ml with 150ml deionized water, put Into the vacuum box, vacuum half an hour to remove the bubbles in the solution. Change the stirring method of the solution to mechanical stirring, slowly add triethanolamine dropwise with a dropper, the solution system will gradually thicken, and control the dropping speed so as not to make the gel too viscous.

Embodiment 2

[0039] Similar to Example 1, only transparent hydrogel is mixed with 3% lauryl dimethyl ammonium chloride solution as the antibacterial agent, and the antibacterial agent mixing ratio is different:

[0040]Take 7.2g of Carbomer 940, put it into 300ml of deionized water and stir, fully swell the Carbomer after 2 days and seal it for storage; take 40ml of Carbomer, add 10ml of water to slightly dilute and stir evenly, prepare 5g of glycerin, polyethylene glycol Alcohol 2g, Tween 0.3g, stirred and dissolved, dissolved well, poured into carbomer and stirred, added 1ml of 3% lauryl dimethyl ammonium chloride solution, added 150ml of deionized water to dilute to 200ml, put in Vacuum box, vacuum for half an hour to remove air bubbles in the solution. Change the stirring method of the solution to mechanical stirring, slowly add triethanolamine dropwise with a dropper, the solution system will gradually thicken, and control the dropping speed so as not to make the gel too viscous.

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Abstract

The invention relates to a bacteriostatic type ultrasonic coupling agent as well as a preparation method and application thereof. The preparation method taking a swollen Carbomer 940 solution as a main component of hydrogel comprises the steps of adding glycerine and polyethylene glycol 400 as adjusting agents, reacting to form transparent hydrogel as a skeleton, and adding dodecyl dimethylammonium chloride, dichlorophenoxyphenol or self-prepared anti-microbial nano-zinc oxide dispersion liquid so as to form transparent or micro-milk white hydrogel. The preparation method has the beneficial effects that the attenuation coefficient of the bacteriostatic type ultrasonic coupling agent is relatively low, a probe and skin are well wetted, and the bacteriostatic type ultrasonic coupling agent is not dried after coating. The bacteriostatic type ultrasonic coupling agent can be applied to the field of ultrasonic wave coupling diagnosis. The preparation method is simple and suitable for large-scale production. The bacteriostatic type ultrasonic coupling agent has a good dispersion effect and further has an excellent sterilizing effect due to the Schoddky effect.

Description

technical field [0001] The invention relates to a preparation method of an antibacterial ultrasonic coupling agent and its product and application, which are used in the field of ultrasonic coupling diagnosis. technical background [0002] During ultrasonic diagnosis, when the ultrasonic wave is incident on the interface of two different media, the greater the impedance of the two, the less the sound energy will pass through the interface and continue to another medium. When the ultrasonic diagnostic instrument is in direct contact with the skin, the presence of air will As a result, ultrasound cannot reach and enter the human body. Sound waves cannot travel effectively through air at the ultrasonic frequencies commonly used in nondestructive testing. In addition to the attenuation of the air, the acoustic impedance of the air does not match the wear-resistant layer of the probe and the general material to be tested. Even a very narrow air gap between the probe and the wor...

Claims

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Application Information

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IPC IPC(8): A61K49/22A61K33/30A61K31/14A61K31/085A61P31/02A61P31/04
CPCA61K31/085A61K31/14A61K33/30A61K49/226A61P31/02A61P31/04
Inventor 何丹农严一楠杨迪诚刘训伟金彩虹
Owner SHANGHAI NAT ENG RES CENT FORNANOTECH
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