The production process of one-step production of methyl anthranilate

Abstract

The invention relates to a production process for producing methyl anthranilate in one step. The technical scheme is that the specific steps are as follows: (1) below 0°C, add N-chlorophthalimide, methanol and water into the reaction vessel, wherein N-chlorophthalimide and methanol The molar ratio is 1:2~1:20; (2) According to the molar ratio of liquid caustic soda and N-chlorophthalimide is 1.2:1~3:1, add liquid caustic soda dropwise and stir 20 minutes; (3) After raising the temperature to 50-80°C and reacting for one hour, the temperature was naturally lowered, and the layers were separated after standing for ten hours, and the product methyl anthranilate was obtained in the lower layer. Beneficial effects are: the yield of the present invention is very high, less equipment is required for production, and the cost is low; the synthetic process of methyl anthranilate is completed in one reaction vessel; the waste water produced in the production process is less; and the indicators of COD and ammonia nitrogen are greatly improved. Reduced, little environmental pollution, simple production, safe, suitable for industrial production.

Description

technical field [0001] The invention relates to a preparation method of methyl anthranilate, in particular to a production process for producing methyl anthranilate in one step. Background technique [0002] Methyl anthranilate, also known as methyl anthranilate, the chemical formula is C 8 h 9 NO 2 , molecular weight 151.16, colorless crystal or light yellow liquid. Slightly soluble in water, insoluble in glycerin. The boiling point is 273°C, and the melting point is 24-25°C. It is a single spice with strong aroma and long-lasting fragrance. It is one of the edible spices. It is mostly used as a fragrance ingredient. It is abundant in grapes. It is mainly used in the preparation of grape, citrus loganberry, strawberry and watermelon flavors, and is also a necessary raw material for the preparation of artificial orange oil. Methyl anthranilate can also produce more than 60 kinds of spices. With the increase of human demand for edible spices, seeking industrial synthet...

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Problems solved by technology

Among them, the amidation degradation method of phthalic anhydride is the most widely used, but it will produce a large amount of high-salt and high-concentration organic waste water, and the pollution is very large. For example, the Chinese patent document publication number is 101948400B, and the patent name is "Preparation method of methyl anthranilate", First, use phthalic anhydride and ammonia water as raw materials to generate amine o-formamide benzoate through amidation reaction, then add sodium hydroxide solution to generate sodium o-formamide benzoate through displacement reaction, remove the ammonia molecules in the reaction solution, and then add Methanol solution and sodium hypochlorite solution react to form methyl anthranilate in paste form, dissolve the methyl anthranilate in water after heating the paste form, finally distill the mixture of methyl anthranilate and water to obtain anthranilic acid methyl ester

And o-nitrobenzoic acid reduction, esterification method not only uses expensive raw material o-nitrobenzoic acid, its raw material price is ten times of the current anthranilic acid selling price, and first adopts sodium sulfide or iron powder reduction method, Then direct esterification produces a large amount of waste water, and anthranilic acid forms an inner salt, uses a large amount of acid catalyst, and the esterification yield is very low

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