Composite iodophor disinfectant and preparation method thereof
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A disinfectant, iodophor technology, applied in pharmaceutical formulations, drug combinations, active ingredients of iodine compounds, etc., can solve the problems of poor product stability, required equipment, yellowing, etc., and achieve the goal of improving bad characteristics and reducing production costs. Effect
Inactive Publication Date: 2018-12-21
澳洁(辽宁)医药科技有限公司
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[0007] According to the properties and characteristics of the main raw materials of traditional iodophors, it can be seen that the mainstream iodine products on the market are mainly ether iodine and ketone iodine. The disadvantages are that the product is not highly dispersible, the liquid is viscous and should not be applied evenly, the product has poor stability, strong irritation, and serious yellowing, etc.; the production process of ketone-iodine is due to the characteristics of raw materials used, and the disadvantage is that the production needs complexation technology and the production cycle is long. , complex process, many equipment required, easy to generate smoke and dust, more labor input, etc.
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preparation example Construction
[0016] The preparation method adopted is:
[0017] 1) Stir the iodine and potassium iodide uniformly for 3-5 minutes, add the mixture into the alkylphenol polyoxyethylene ether, and stir uniformly for 2 hours to obtain the mixture A;
[0018] 2), add sorbitan monostearate and isopropanol into deionized water and stir to dissolve, add polyvinylpyrrolidone and continue to stir evenly to make solution B;
[0019] 3) Mix and stir A and B for 0.5-1 hour, then seal them together and place them in shading for 24 hours, then stir evenly for 1 hour to obtain C;
[0020] 4), add chitosan, tea tree oil, palm oil in solution C, stir 0.5-1 hour, make iodophor disinfectant.
Embodiment
[0022] A kind of iodophor disinfectant provided by the invention, its raw material comprises by weight: 0.91 part of iodine, 0.91 part of potassium iodide, 6.15 parts of polyvinylpyrrolidone, 2.7 parts of alkylphenol polyoxyethylene ether, 0.35 part of chitosan, tea tree oil 0.6 parts, 0.4 parts of palm oil, 0.15 parts of sorbitan monostearate, 0.1 parts of isopropanol, and 125 parts of deionized water.
[0023] 1. Stir iodine and potassium iodide uniformly for 3-5 minutes, add the mixture into alkylphenol polyoxyethylene ether, and stir uniformly for 2 hours to obtain mixture A;
[0024] 2. Add sorbitan monostearate and isopropanol to deionized water and stir to dissolve, add polyvinylpyrrolidone and continue stirring to make solution B;
[0025] 3. Mix and stir A and B for 0.5-1 hour, then place them together in airtight shading for 24 hours, then stir evenly for 1 hour to obtain C;
[0026] 4. Add chitosan, tea tree oil and palm oil to solution C, and stir for 0.5-1 hour t...
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Abstract
The invention discloses a composite iodophor disinfectant and a preparation method thereof. The composite iodophor disinfectant comprises the following raw materials in parts by weight: 0.5-1 part ofiodine, 0.5-1 part of potassium iodide, 6-7 parts of polyvinylpyrrolidone, 2-3 parts of alkylphenol ethoxylates, 0.1-0.5 part of chitosan, 0.5-1 part of tea tree oil, 0.1-1 palm oil, 0.1-1 part of sorbitan monostearate, 0.1-1 part of isopropanol and 110-125 parts of deionized water. The preparation method is carried out under a sealed unheating condition, the effective iodide component is slightlylost, no waste gas or waste liquid is discharged, the preparation method is simple in process and operation, low in working intensity, high in automation degree and easy in parameter control, the content and the production efficiency of the formula can be effectively improved, a very remarkable effect can be achieved, and the preparation process has a great development potential.
Description
technical field [0001] The drug development technology involved in the present invention relates to the improvement of the traditional iodophor preparation production process, through the new process, the bad characteristics of the traditional iodophor production process are improved, the production cost is reduced, the disinfection effect of the iodophor is increased, and the auxiliary effect is increased . Background technique [0002] Iodophors are classified as iodine-containing preparations in the disinfection industry. Iodine-containing preparations are defined as disinfectants with iodine as the main bactericidal component, mainly including: iodine tincture and iodophors. Iodophor is defined as a complex of iodine with polyalcohol ethers and polyvinylpyrrolidone surfactants. [0003] Iodine, this product is gray-black or blue-black, flaky crystals or lumps with metallic luster, heavy, brittle, with special odor, and can volatilize at room temperature. Iodine is easi...
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