Sunflower head and semen coicis complex composition and application thereof in liver injury treatment

A technology of coix seed and sunflower plate is applied in the directions of drug combination, medical preparations containing active ingredients, and pharmaceutical formulas, which can solve the problems of inability to take long-term use and side effects, and achieve the enhancement of liver repair ability, alleviation of side effects, and enhancement of liver cells. the effect of the ability

Inactive Publication Date: 2018-12-21
JILIN UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The invention provides a compound composition of sunflower plate and coix seed, which uses sunflower plate and coix seed of the same medicine and food to form a compound preparation for the treatment of liver injury diseases, and solves the side effects and inability of existing drugs for treating liver injury. Problems with long-term use

Method used

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  • Sunflower head and semen coicis complex composition and application thereof in liver injury treatment
  • Sunflower head and semen coicis complex composition and application thereof in liver injury treatment
  • Sunflower head and semen coicis complex composition and application thereof in liver injury treatment

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Step 1) Crush 25kg of sunflower discs to 30 mesh, add 20 times the mass of deionized water, soak fully, add 0.2% mass fraction of neutral protease at pH 6.0-7.0, and enzymatically at 40-50°C Decompose for 2 hours, fully stir evenly, adjust the pH to 8 with sodium hydroxide, and fully react for 60 minutes at 45-50°C in the reactor to obtain the sunflower disc extract;

[0036] Step 2) Grind 25kg of coix seed to 30 mesh, add 20 times the mass of ethanol, soak for 2 hours, fully react in the reactor at 45-50°C for 2 hours, and obtain the coix seed extract;

[0037] Step 3) Filter the water extract obtained in step 1) and suspend and evaporate to dryness at 80-90°C to obtain a solid powder;

[0038] Step 4) Filter the alcohol extract obtained in step 2) and suspend and evaporate to dryness at 55-60°C to obtain a solid powder;

[0039] Step 5) Mix the solid powder in step 3) and step 4) uniformly at a mass ratio of 2:1, dissolve in 2 times distilled water to make a compound...

Embodiment 2

[0041] Step 1) Crush 30kg of sunflower discs to 30 mesh, add 20 times the mass of deionized water, soak fully and add 0.2% mass fraction of neutral protease to enzymatically hydrolyze at pH 6.0-7.0 and temperature 40-50°C 2 hours, fully stirred evenly, adjusted the pH to 8 with sodium hydroxide, fully reacted in the reactor at 45-50°C for 60 minutes, and obtained the sunflower disc extract;

[0042] Step 2) Grind 20kg of coix seed to 30 mesh, add 20 times the mass of ethanol, soak for 2 hours, fully react in the reactor at 45-50°C for 2 hours, and obtain the coix seed extract;

[0043] Step 3) Filter the water extract obtained in step 1) and suspend and evaporate to dryness at 80-90°C to obtain a solid powder;

[0044] Step 4) Filter the alcohol extract obtained in step 2) and suspend and evaporate to dryness at 55-60°C to obtain a solid powder;

[0045] Step 5) Mix the solid powder in step 3) and step 4) uniformly at a mass ratio of 2:1, dissolve in 2 times distilled water t...

Embodiment 3

[0047] Step 1) Crush 35kg of sunflower discs to 30 mesh, add 20 times the mass of deionized water, soak fully and add 0.2% mass fraction of neutral protease to enzymatically hydrolyze at pH 6.0-7.0 and temperature 40-50°C 2 hours, fully stirred evenly, adjusted the pH to 8 with sodium hydroxide, fully reacted in the reactor at 45-50°C for 60 minutes, and obtained the sunflower disc extract;

[0048] Step 2) 15kg of coix seed, crushed to 30 mesh, added 20 times the mass of ethanol, soaked for 2 hours, fully reacted in the reactor at 45-50°C for 2 hours, and obtained the coix seed extract;

[0049] Step 3) Filter the water extract obtained in step 1) and suspend and evaporate to dryness at 80-90°C to obtain a solid powder;

[0050] Step 4) Filter the alcohol extract obtained in step 2) and suspend and evaporate to dryness at 55-60°C to obtain a solid powder;

[0051] Step 5) Mix the solid powder in step 3) and step 4) at a mass ratio of 2:1, and dissolve in 2 times distilled wa...

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PUM

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Abstract

The invention provides a sunflower head and semen coicis complex composition and application thereof in liver injury treatment. The sunflower head and semen coicis complex composition is prepared frommedicinal and edible sunflower head and semen coicis and is used for treating liver injury. The sunflower head and semen coicis complex composition solves the problems that an existing medicine is subjected to side effects and cannot be eaten for a long term; and the sunflower head and semen coicis coordinately act to improve the liver recovery and promote the discharge of liver metabolites.

Description

technical field [0001] The invention discloses a sunflower plate coix seed compound composition, which is composed of sunflower plate and coix seed, has obvious effects on the treatment of liver damage diseases, and belongs to the technical field of traditional Chinese medicine pharmacy. Background technique [0002] Drug-induced liver injury has gradually become a problem that cannot be ignored in medical treatment and pharmaceuticals. Drug-induced liver injury refers to liver function caused by the drug itself and its metabolites, or immune system damage caused by hypersensitivity reactions caused by its metabolites. Common drugs that are prone to drug-induced liver injury include antibiotics, anti-tuberculosis drugs, Chinese herbal medicines, antipyretic analgesics, halothane anesthetics, and antineoplastic drugs. [0003] The development of existing drugs for liver damage repair, such as interferon and bicyclol, has become a medical concern, but the popularization and ap...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8994A61P1/16
CPCA61K36/28A61K36/8994A61K2236/19A61K2236/333A61P1/16A61K2300/00
Inventor 付学奇戴惠咛李婉南高波韩露韩笑胡峻涵沈方舟
Owner JILIN UNIV
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