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Medical modified collagen matrix drug loading sponge and preparation method thereof

A collagen matrix and matrix technology, applied in the field of modified collagen matrix drug-loaded medical sponge and its preparation, can solve the problems of small loading dose and insignificant drug effect, and achieve large drug-loading dose, significant drug effect, and bonding Effects with just the right intensity

Inactive Publication Date: 2018-12-21
SICHUAN LIZHI JIUCHUANG INTPROP OPERATION CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to overcome the problems of small drug loading and insignificant drug effect in the existing collagen matrix medical sponge, and provide a modified collagen matrix drug-loaded medical sponge and its preparation method

Method used

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  • Medical modified collagen matrix drug loading sponge and preparation method thereof
  • Medical modified collagen matrix drug loading sponge and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032](1) With microbial modifier, press microbial modifier 15%, peptone 2%, agar 0.5% and water 80% after mixing, after cultivating at 20 ℃ for 2h, obtain modified finishing liquid; Described microbial modifier The mass ratio of cellulobacterium fusarium, Acetobacter xylinum and yeast is 1:1:3; the drug carrier liquid is prepared by mixing the bletilla striata polysaccharide drug carrier with a solid-liquid ratio of 2:1 and pure water;

[0033] (2) taking the collagen solution with a mass fraction of 20%, and respectively irradiating the pores with ultraviolet light to make a porous collagen matrix with a porosity of 80%;

[0034] (3) Immerse the porous collagen matrix prepared in step (2) into the modified finishing solution prepared in step (1), and perform modification treatment at 30° C. for 20 h.

[0035] (4) Take out the modified porous collagen matrix in the step (3), at 60Kw.s / cm 2 Under the ultraviolet irradiation intensity, the irradiation time is 20h, carry out ul...

Embodiment 2

[0038] (1) Use microbial modifier, press microbial modifier 30%, peptone 3%, after agar 2% and water 60% mix, obtain modified finishing solution after cultivating at 40 ℃ for 1h; Described microbial modifier The mass ratio of cellulobacterium fusarium, Acetobacter xylinum and yeast is 1:3:5; chitosan drug carrier is mixed with pure water at a solid-liquid ratio of 4:1 to prepare a drug carrier liquid;

[0039] (2) Take the collagen solution with a mass fraction of 40%, and use the physical cross-linking pore-forming method to prepare a porous collagen matrix with a porosity of 60%;

[0040] (3) Immerse the porous collagen matrix prepared in step (2) in the modified finishing solution prepared in step (1), and perform modification treatment at 50° C. for 16 hours.

[0041] (4) Take out the modified porous collagen matrix in the step (3), at 20Kw.s / cm 2 Under the intensity of ultraviolet irradiation, the irradiation time is 40h, ultraviolet sterilization is carried out to kill ...

Embodiment 3

[0044] (1) With microbial modifier, after mixing 20% ​​of microbial modifier, 2.5% of peptone, 1% of agar and 70% of water, after cultivating at 30°C for 1.5h, a modified finishing solution is obtained; The mass ratio of cellulobacterium fusarium, Acetobacter xylinum and saccharomyces in the agent is 1:2:4; the drug carrier liquid is prepared by mixing the cartin hydrochloride drug carrier with pure water at a solid-liquid ratio of 5:1;

[0045] (2) Take the collagen solution with a mass fraction of 30%, and use chemical cross-linking pore-forming methods to prepare porous collagen matrices with a porosity of 65%;

[0046] (3) Immerse the porous collagen matrix prepared in step (2) into the modified finishing solution prepared in step (1), and perform modification treatment at 60° C. for 5 hours.

[0047] (4) Take out the modified porous collagen matrix in the step (3), at 40Kw.s / cm 2 Under the intensity of ultraviolet irradiation, the irradiation time is 30h, ultraviolet ste...

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Abstract

The invention discloses medical modified collagen matrix drug loading sponge. The sponge is prepared by carrying out modification treatment on a porous collagen matrix through a microorganism modifying agent, and finishing loading of a drug carrier by utilizing a polar group on the surface of the modified porous collagen matrix, wherein the microorganism modifying agent comprises falciform cellulose bacteria, acetobacter xylinum and saccharomycetes; the drug carrier is a drug which does not react with the porous collagen matrix and is hydrophilic. According to the medical modified collagen matrix drug loading sponge disclosed by the invention, the quantity of hydrophilic groups on the surface of the porous collagen matrix and the hydrophilic polarity are increased, so that the drug loadingdosage of the modified collagen matrix on hydrophilic drugs is increased; the finally prepared medical modified collagen matrix drug loading sponge has a great drug loading dosage, a remarkable medical effect and a lasting medical effect and can be widely applied to medical utilization of various departments.

Description

technical field [0001] The invention relates to the field of new medical materials, in particular to a modified collagen matrix drug-loaded medical sponge and a preparation method thereof. Background technique [0002] There are many kinds of existing medical sponges, which can be classified into synthetic and biological according to the material of the sponge. In view of the increasingly high requirements for the biocompatibility of medical sponges, biological medical sponges have also become the main materials used. The material sources of biological sponges that are currently studied mainly include collagen, chitin and its derivatives, and alginate. Natural biopolymer materials have the characteristics of resolvability, and different materials have their unique biological activities, which is an important trend in the future development of the field of medical materials. Among them, collagen is the main extracellular matrix component, with a triple helical structure, wh...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00A61L24/10A61L24/00C08J9/40C08L89/00
CPCA61L26/0033A61L24/001A61L24/0015A61L24/0036A61L24/102A61L26/0061A61L26/0066A61L26/0085A61L2400/04C08J9/40C08J2389/00
Inventor 舒春柳袁迎春
Owner SICHUAN LIZHI JIUCHUANG INTPROP OPERATION CO LTD
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