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Medical carrying sponge with chitosan modified porous gel matrix and preparation method

A technology of chitosan modification and gel matrix, which is applied in the fields of application, medical science, surgery, etc., can solve the problems of insignificant drug effect and small loading dose, and achieve significant drug effect, large drug loading dose, and close The effect of water polarity enhancement

Inactive Publication Date: 2019-01-18
SICHUAN LIZHI JIUCHUANG INTPROP OPERATION CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to overcome the problem of small drug loading dosage and insignificant drug effect in the existing chitosan porous gel matrix medical sponge, and provide a chitosan modified porous gel matrix drug-loaded medical sponge and its preparation method

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] (1) with microbial modifier, by microbial modifier 30%, peptone 6%, after agar 8% and 70% water are mixed, after cultivating at 40 ℃ for 1h, obtain modified finishing liquid; The mass ratio of lactobacillus, bifidobacterium and yeast is 2:1:3; the drug carrier liquid is prepared by mixing the bletilla striata polysaccharide drug carrier with the solid-liquid ratio of 3:1 and pure water;

[0035] (2) Chitosan solution with a mass fraction of 40% is used as a synthetic raw material, and polyethylene glycol is used as a crosslinking agent to obtain a chitosan porous gel through a chemical crosslinking reaction.

[0036] (3) The chitosan porous gel matrix prepared in step (2) was immersed in the modified finishing solution prepared in step (1), and modified at 30° C. for 25 hours.

[0037] (4) take out the chitosan porous gel matrix through modification in step (3), at 60Kw.s / cm 2 Under the ultraviolet irradiation intensity, the irradiation time is 20h, carry out ultraviol...

Embodiment 2

[0040] (1) With microbial modifier, after mixing microbial modifier 25%, peptone 5%, agar 6% and 80% water, obtain modified finishing solution after cultivating at 30°C for 1.5h; The mass ratio of lactobacillus, bifidobacterium and yeast in the agent is 1.5:1:2; the drug carrier liquid is prepared by mixing the chitosan drug carrier with the solid-liquid ratio of 4:1 and pure water;

[0041] (2) Chitosan solution with a mass fraction of 30% is used as a synthetic raw material, and polyethylene glycol is used as a crosslinking agent to obtain a chitosan porous gel through a chemical crosslinking reaction.

[0042] (3) Immerse the chitosan porous gel matrix prepared in step (2) in the modified finishing liquid prepared in step (1), and perform modification treatment at 50° C. for 20 h.

[0043] (4) take out the chitosan porous gel matrix through modified treatment in step (3), at 20Kw.s / cm 2 Under the ultraviolet irradiation intensity, the irradiation time is 40h, carry out ult...

Embodiment 3

[0046] (1) Use microbial modifier, press microbial modifier 20%, peptone 4%, after agar 5% and 85% water are mixed, after cultivating 2h at 20 ℃, obtain modified finishing solution; Described microbial modifier The mass ratio of lactobacillus, bifidobacteria and yeast in the medium is 1:1:3; the drug carrier liquid is prepared by mixing the cartin hydrochloride drug carrier with the solid-liquid ratio of 2:1 and pure water;

[0047] (2) get the collagen solution that mass fraction is 30%, make the chitosan porous gel matrix of porosity 65% ​​respectively with chemical cross-linking porosity mode;

[0048] (3) A chitosan solution with a mass fraction of 40% is used as a synthetic raw material, and polyethylene glycol is used as a crosslinking agent to obtain a chitosan porous gel through a chemical crosslinking reaction.

[0049] (4) take out the chitosan porous gel matrix through modified treatment in step (3), at 40Kw.s / cm 2 Under the intensity of ultraviolet irradiation, th...

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Abstract

The invention discloses a medical carrying sponge with chitosan modified porous gel matrix and a preparation method. A medical sponge load with chitosan modified porous gel matrix is prepare by modifying chitosan porous gel matrix with microbial modifier. And utilize polar groups on that surface of modified chitosan porous gel matrix to complete loading of drug carrier. The microbial modifier comprises lactobacillus, bifidobacterium and yeast; The drug carrier is a drug that does not react with the chitosan porous gel matrix and is hydrophilic. A surface of that chitosan porou gel matrix is biochemically modified to increase the numb of hydrophilic groups and the hydrophilic polarity of the surface of the chitosan porous gel matrix, thereby increasing the drug load of the chitosan porou gel matrix to hydrophilic drugs. The final prepared chitosan modified porous gel matrix drug-loaded medical sponge has the advantages of large drug loading amount, remarkable drug application effect, lasting drug effect, good biocompatibility and wide application.

Description

technical field [0001] The invention relates to the field of new medical materials, in particular to a chitosan-modified porous gel matrix drug-loaded medical sponge and a preparation method thereof. Background technique [0002] There are many kinds of existing medical sponges, which can be classified into synthetic and biological according to the material of the sponge. In view of the increasingly high requirements for the biocompatibility of medical sponges, biological medical sponges have also become the main materials used. The material sources of biological sponges that are currently studied mainly include collagen, chitin and its derivatives, and alginate. Natural biopolymer materials have the characteristics of resolvability, and different materials have their unique biological activities, which is an important trend in the future development of the field of medical materials. Among them, collagen is the main extracellular matrix component, with a triple helical st...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/08A61L24/00C08J9/40C08L5/08
CPCC08J9/40A61L24/0031A61L24/0036A61L24/08C08J2305/08C08L5/08
Inventor 舒春柳洪艳
Owner SICHUAN LIZHI JIUCHUANG INTPROP OPERATION CO LTD
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