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Refining method and production system of sodium benzoate

A technology of sodium benzoate and purification method, applied in the separation/purification of carboxylic acid compounds, organic chemistry and other directions, can solve the problems such as inability to guarantee the purity and clarity of sodium benzoate, no refined sodium benzoate, decomposition of sodium benzoate, etc. Instability and the effect of low clarity, improved clarity and stability, stable quality

Active Publication Date: 2018-12-21
湖南新绿方药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the synthesis of sodium benzoate usually takes benzoic acid as raw material, and then neutralizes at high temperature with sodium hydroxide, sodium carbonate or sodium bicarbonate. In the synthesis of sodium benzoate, raw material benzoic acid is weak acid, slightly soluble in water, benzene Formic acid exists in sodium benzoate in the form of insoluble matter. At the same time, sodium benzoate is a strong base and weak acid salt. The pH value of the surrounding environment is lower than 6.5, which is more likely to cause the decomposition of sodium benzoate, resulting in the possibility of clarity of sodium benzoate solution in the production process. Qualified, but after a period of time, the clarity may be unqualified, and the purity and clarity of sodium benzoate cannot be guaranteed
At the same time, there are no relevant research and technical reports in the art on the use of edible grade sodium benzoate as a raw material for the preparation of pharmaceutical grade refined sodium benzoate

Method used

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  • Refining method and production system of sodium benzoate
  • Refining method and production system of sodium benzoate
  • Refining method and production system of sodium benzoate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] The present embodiment of the production system of the present invention provides a refined production system of pharmaceutical grade sodium benzoate, comprising a dissolution tank 1, a filter one 2, a filter two 3, a filter three 4 and a drier 6; the drier 6 can adopt a scraper Plate dryer or drying machine. Described dissolving tank 1 is provided with stirring device 101 and heating device 102; Described dissolving tank 1 is provided with water inlet 105, feed port 106, discharge port 107 and return material port 108, and the discharge port 107 of dissolving tank 1 is provided with Filter material 103, described filter material 103 preferably adopts non-woven fabric; Described filter one 2, filter two 3, filter three 4 are respectively provided with feed inlet 201,301,401 and discharge outlet 202,302 , 402; the dissolving tank 1 is provided with the inlet 201 of pipeline connection filter one 2, the outlet 202 of filter one 2 connects the inlet 301 of filter two 3, th...

Embodiment 2

[0052] Based on the production system described in embodiment 1, the refining method of sodium benzoate of the present invention realizes as follows: open the feed inlet 106 of dissolving tank 1, sodium benzoate is dropped in dissolving tank 1, inject a certain amount of water by water inlet 105, Turn on the stirring device 101, raise the temperature of the liquid through the heating conduit 102, put activated carbon into the dissolving tank 1, close the feed port 106 of the dissolving tank 1, and stir for a certain period of time. Open the valve at the bottom of the dissolution tank 1, the liquid in the dissolution tank 1 is filtered through the non-woven fabric 103 and enters the filter one 2, and then enters the filter two 3 from the filter one 2, and records the pH tester at the outlet of the filter two 3 The displayed pH value, the pH value of the liquid treated by the filter two 3 is qualified, the valve one 304 is controlled to make the liquid in the filter two 3 enter t...

Embodiment 3

[0054] Based on the production system described in embodiment 1, the refining method of sodium benzoate of the present invention realizes as follows: open the feed inlet 106 of dissolving tank 1, sodium benzoate is dropped in dissolving tank 1, inject a certain amount of water by water inlet 105, Turn on the stirring device 101, raise the temperature of the liquid through the heating conduit 102, put activated carbon into the dissolving tank 1, close the feed port 106 of the dissolving tank 1, and stir for a certain period of time. Open the valve at the bottom of the dissolving tank 1, the liquid in the dissolving tank 1 is filtered through the non-woven fabric 103 and enters the filter one 2, records the pH value shown by the pH tester at the outlet of the filter one 2, and the material processed by the filter one 2 If the pH value of the liquid is unqualified, control valve one 204 and valve four 109 to make the liquid in the filter one 2 return to the dissolution tank 1 for ...

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Abstract

The invention discloses a refining method and a production system of sodium benzoate. The medicinal grade sodium benzoate is prepared by taking food grade sodium benzoate as a raw material and throughdissolution, active carbon decoloration, multi-grade filtration and drying treatment. The refining method is stable and feasible, and accurately controllable, and the quality is stable. The purity ofthe sodium benzoate product is higher than or equal to 99.4%, the product yield is higher than or equal to 92-95%, especially a plurality of indexes such as the clearness and the color of the productare dramatically improved, and the sodium benzoate completely conforms to the medicinal grade standard.

Description

technical field [0001] The present invention relates to the refining technical field of sodium benzoate, more specifically, relate to a kind of refining method and production system of sodium benzoate. Background technique [0002] Sodium benzoate, also known as sodium benzoate, is a white granule or crystalline powder, odorless or slightly benzoin-like, slightly sweet and astringent. Sodium benzoate is stable in the air and easily soluble in water. It has the function of sterilizing and inhibiting the growth of bacteria. It is widely used as a preservative for medicines, food, tobacco leaves, cosmetics, toothpaste, spices, etc. It can also be used for packaging paper pulp, latex paint, etc. And to prevent metal corrosion in the machine, it is widely used in countries all over the world. [0003] At present, the synthesis of sodium benzoate usually takes benzoic acid as raw material, and then neutralizes at high temperature with sodium hydroxide, sodium carbonate or sodium ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C63/08C07C51/42
CPCC07C51/42C07C63/08
Inventor 唐波彭立辉
Owner 湖南新绿方药业有限公司
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