Double-targeted phthalocyanine anti-cancer photosensitizer and preparation method thereof
A technology for phthalocyanines and photosensitizers, which is applied in the field of asymmetrically substituted phthalocyanine complexes with aza aromatic rings and the preparation thereof, and achieves the effects of low cost, mild reaction conditions and easy availability of raw materials
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[0034] The preparation method of the asymmetrically substituted phthalocyanine complexes with tumor-specific and mitochondrial localization targets, the experimental steps are as follows:
[0035] (1) Synthesis of 1a
[0036] First, the compounds tetraethylene glycol (9.706 g, 50.0 mmol) and p-toluenesulfonyl chloride (2.387 g, 12.5 mmol) were added to a 250 ml round bottom flask, followed by anhydrous CH 2 Cl 2(150 ml), fully stirred and dissolved, then added triethylamine (6.324g, 62.5 mmol), and reacted at room temperature under nitrogen protection for 12 h; after the reaction, extracted with 1mol / L hydrochloric acid solution and saturated sodium chloride solution respectively Three times, the organic phase was collected, dried over anhydrous sodium sulfate, and the CH was removed under reduced pressure 2 Cl 2 , and then eluted with dichloromethane and methanol, and separated by silica gel column chromatography to obtain compound 1a 2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy...
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