Application of flavonoid small molecule compound in preparing drugs for suppressing oxidative stress diseases induced by hexavalent chromium ions
A technology of small molecular compounds and hexavalent chromium ions, which can be used in the active ingredients of hydroxyl compounds, drug combinations, respiratory diseases, etc., and can solve problems such as inflammatory reaction tissue and damage
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Embodiment 1
[0039]Reactive oxygen species (ROS) are a by-product of biological aerobic metabolism, including oxygen ions, peroxides and oxygen-containing free radicals. ROS are by-products of normal oxygen metabolism and play a major role in cell signaling and maintaining homeostasis. However, under the action of external factors, the amount of ROS will increase dramatically. This manifestation is a hallmark of oxidative stress. When we treated cells with hexavalent chromium ions, the amount of intracellular ROS was significantly increased compared with the control group, and when we added resveratrol for protection, the amount of ROS was significantly reduced (such as figure 1 shown). At the same time, with taxifolin (such as figure 2 Shown), quercetin and luteolin treatment also obtained similar results.
Embodiment 2
[0041] Human lung bronchial epithelial cells are sensitive to ROS and are easily damaged by ROS. Studies have shown that oxidative stress is involved in the occurrence and development of lung injury. Using natural antioxidants to protect lung bronchial epithelial cells and maintain their cell viability is a way to protect the lungs. An effective method for internal cells. The survival rate of human pulmonary bronchial epithelial cells in the hexavalent chromium ion injury group was (70±2.96)%. After adding different concentrations of resveratrol, the survival rate of Beas-2B cells increased with the increase of resveratrol concentration. The survival rate of cells reached (87.3±1.21)% when treated with 50μM / L resveratrol. The results show that resveratrol has a protective effect on cells (such as image 3 shown). At the same time, with taxifolin (such as Figure 4 Shown), quercetin and luteolin treatment also obtained similar results.
Embodiment 3
[0043] In patients with chronic obstructive pulmonary disease, the expression levels of IL-1β and TNF-α inflammatory mediators were significantly increased. When we treated lung bronchial epithelial cells with hexavalent chromium ions, we found that IL-1β and TNF-α The expression levels of inflammatory factors increased significantly, and the expression levels of IL-1β and TNF-α inflammatory mediators decreased when resveratrol was used for protection (such as Figure 5 shown). At the same time, with taxifolin (such as Figure 6 Shown), quercetin and luteolin treatment also obtained similar results.
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