Selenium-doped mesoporous silica antibacterial material and preparation method thereof

A technology of mesoporous silica and antibacterial materials, applied in the field of antibacterial materials, can solve problems such as tissue damage, and achieve the effects of good dispersion, strong repeatability and uniform particles

Inactive Publication Date: 2019-01-11
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It should be pointed out that excessive inorganic nano-selenium will cause certain damage to the tissue. In addition, the agglomeration of nano-selenium will have a greater impact on its

Method used

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  • Selenium-doped mesoporous silica antibacterial material and preparation method thereof
  • Selenium-doped mesoporous silica antibacterial material and preparation method thereof
  • Selenium-doped mesoporous silica antibacterial material and preparation method thereof

Examples

Experimental program
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Example Embodiment

[0027] Example 1

[0028] Choose analytically pure sodium selenite, ascorbic acid, cetyltrimethylammonium bromide (CTAB), ammonium fluoride (NH 4 F), Ethyl Orthosilicate (TEOS), by this preparation method, 10% selenium-doped nano-scale MSNs are synthesized.

[0029] The specific steps are:

[0030] (1) First, weigh 0.1g of selenite and 0.4g of ascorbic acid and add them to 10mL of deionized water, stir well to dissolve them in the water, and set aside for later use;

[0031] (2) Weigh 0.36g CTAB, 0.6g NH 4 F, then add 80mL deionized water, the reaction temperature is 80℃, fully stir, the rotor speed is controlled at 200~300rpm;

[0032] (3) After (2) the reaction is carried out for 5 minutes, the two solutions in the first step are quickly mixed and added to the reaction system for 1 hour, the temperature is maintained at 80°C, and the rotor speed is controlled at 200 rpm;

[0033] (4) After reacting for 1 hour, add 1.8 mL of TEOS dropwise to the reaction system, react for 1 hour, and ke...

Example Embodiment

[0043] Example 2

[0044] Select analytically pure sodium selenite, ascorbic acid, cetyltrimethylammonium bromide (CTAB), triethanolamine (TEA), ethyl orthosilicate (TEOS), and synthesize 5% selenium content by this preparation method Nano-scale MSNs. The specific steps are as follows: (1) Firstly, weigh 0.05 g of selenite and 0.4 g of ascorbic acid and add them to 10 mL of deionized water, stir thoroughly to mix them, and set aside for later use;

[0045] (2) Weigh 0.36g CTAB and 0.2g TEA, then add 80mL deionized water, the reaction temperature is 80℃, fully stir, the rotor speed is controlled at 200rpm;

[0046] (3) After (2) the reaction is carried out for 5 minutes, the two solutions in the first step are quickly mixed and added to the reaction system for 1 hour, the temperature is maintained at 80°C, and the rotor speed is controlled at 200 rpm;

[0047] (4) After reacting for 1 hour, add 1.8 mL of TEOS dropwise to the reaction system, react for 1 hour, and keep the temperature ...

Example Embodiment

[0050] Example 3

[0051] Select analytically pure sodium selenite, ascorbic acid, cetyltrimethylammonium chloride (CTAC), ammonium fluoride (NH 4 F), Ethyl Orthosilicate (TEOS), by this preparation method, 10% selenium-doped nano-scale MSNs are synthesized. The specific steps are:

[0052] (1) Firstly, weigh 0.1g of selenite and 0.4g of ascorbic acid and add them to 10mL of deionized water, stir well to mix them, and set aside for later use;

[0053] (2) Weigh 0.36g CTAC, 0.6g NH 4 F, then add 80mL deionized water, the reaction temperature is 80℃, fully stir, the rotor speed is controlled at 200rpm;

[0054] (3) After the reaction of (2) is carried out for 5 minutes, the two solutions in the first step are quickly mixed and added to the reaction system for 1 hour, the temperature is kept at 80°C, and the rotor speed is controlled at 200 rpm;

[0055] (4) After reacting for 1 hour, add 1.8 mL of TEOS dropwise to the reaction system, react for 1 hour, and keep the temperature at 80°C;

...

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Abstract

The invention relates to a selenium-doped mesoporous silica antibacterial material and a preparation method thereof. Pores of mesoporous silica MSNs are filled with selenium nanoparticles. The above Se/MSNs have the advantages of good dispersity, uniform particle size and adjustable Se loading capacity; and the dispersibility of the Se/MSNs particles is superior to that of pure Se particles, so the Se/MSNs have an excellent antibacterial effect, and is expected to be a nontoxic and harmless antibacterial material.

Description

Technical field [0001] The invention belongs to the field of antibacterial materials, and particularly relates to a selenium-doped mesoporous silica antibacterial material and a preparation method thereof. Background technique [0002] There is an inevitable risk of infection during surgery. The adhesion of bacteria on the surface of biological materials and the subsequent formation of biofilms will cause a series of serious consequences (such as implantation device failure and tissue infection, etc.). Therefore, imparting antibacterial properties to materials has important practical significance. [0003] Selenium is an important trace element necessary for human body. Recent studies have shown that this essential trace element of the human body plays an important role in the normal growth and development of the body’s bones. This life element has similar effects to drugs and bone growth factors, and can effectively stimulate and promote the repair of bone tissue. regeneration. ...

Claims

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Application Information

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IPC IPC(8): C01B33/18C01B19/02B82Y30/00B82Y40/00
CPCB82Y30/00B82Y40/00C01B19/02C01B33/18C01P2002/72C01P2002/85C01P2004/03C01P2004/04C01P2004/64C01P2006/12C01P2006/14C01P2006/16
Inventor 倪似愚崔冉陈晶晶魏媛媛金熙江浩
Owner DONGHUA UNIV
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