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Synthesis and performance research of coumarins Mg2+ fluorescent probe

A fluorescent probe and coumarin-based technology, applied in the field of fluorescent probes, can solve problems such as cardiac arrest, shortness of breath, and prevention of calcium ion absorption, and achieve the effects of low detection limit, high sensitivity, and high anti-interference ability

Inactive Publication Date: 2019-01-11
NANTONG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But the excess concentration of Mg 2+ It can cause shortness of breath, cardiac arrest, and even prevent the body from absorbing calcium ions

Method used

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  • Synthesis and performance research of coumarins Mg2+ fluorescent probe
  • Synthesis and performance research of coumarins Mg2+ fluorescent probe
  • Synthesis and performance research of coumarins Mg2+ fluorescent probe

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] (1), the reaction formula of synthetic 7-hydroxyl-8-coumarin aldehyde:

[0031]

[0032] (2), the specific steps of synthetic 7-hydroxyl-8-coumarin aldehyde:

[0033] Dissolve 7-hydroxycoumarin and hexamethylenetetramine in glacial acetic acid, stir and heat to 70-100°C for reaction, then add hydrochloric acid to the system and stir at 50-90°C; cool, add ice water, Extract with ethyl acetate, then dry the organic phase with anhydrous sodium sulfate, filter under reduced pressure, and remove the solvent by rotary evaporation of the filtrate under reduced pressure to obtain a yellow solid; then recrystallize with absolute ethanol to obtain 7-hydroxy-8-coumarin Urine, the yield is about 18%.

[0034] (3), the reaction formula of synthetic coumarin fluorescent probe:

[0035]

[0036] (4), the specific steps of synthetic coumarin fluorescent probe:

[0037] In a 100ml three-necked flask, the intermediate 7-hydroxyl-8-coumarin aldehyde (0.400g, 2.1mmol) was dissolve...

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Abstract

The invention relates to the field of fluorescent probes, and in particular to a synthesis and performance research of a coumarins Mg2+ fluorescent probe. A specific structural formula is described asthe specification; the fluorescent probe can identify Mg2+ in DMSO (Dimethylsulfoxide). The fluorescent probe has the advantages that the probe has superior selectivity in competition with other ions, and has higher fluorescent sensing property, low detection limit, high sensitivity and high fluorescence quantum yield.

Description

technical field [0001] The invention relates to the field of fluorescent probes, in particular to a coumarin Mg 2+ Synthesis of fluorescent probes and preparation and application of performance research. Background technique [0002] Mg 2+ As an important element to regulate human life activities, it determines whether various physiological activities can be carried out normally. But the excess concentration of Mg 2+ It can cause shortness of breath, cardiac arrest, and even prevent the body from absorbing calcium ions. Therefore, designing a fluorescent chemical sensor that can efficiently identify ions and molecules has attracted more and more attention. Such fluorescent chemical sensors have potential applications in biology, pharmacology, and clinical medicine. [0003] Molecular fluorescent probes have the advantages of fast reaction rate, low detection limit, and generally no damage to living organisms, and have long-term application prospects. The new type of pr...

Claims

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Application Information

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IPC IPC(8): C07D311/16C09K11/06G01N21/64
CPCG01N21/6428G01N21/6486C09K11/06C07D311/16C09K2211/1088
Inventor 汤艳峰王纯黄洋孙同明王淼朱金丽丁津津韩丽玮
Owner NANTONG UNIVERSITY
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