A triamcinolone acetonide acetate cream and preparation method thereof
A technology of triamcinolone acetonide acetate and cream, which is applied in the directions of ointment delivery, pharmaceutical formulation, emulsion delivery, etc., can solve the problems of reduced drug efficacy, fast onset time, and reduced content of active ingredients, etc., and achieves strong skin penetration, The effect of strong practicability and high stability
Active Publication Date: 2019-01-15
珠海安生凤凰制药有限公司
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Problems solved by technology
[0003] Chinese patent application CN100435801C discloses a medicine for external use for treating skin diseases and a preparation method thereof. The medicine is mainly made of dexamethasone acetate, camphor, menthol, triamcinolone acetonide acetate, urea and acetylsalicylic acid. Anti-inflammatory, anti-itching, detumescence effects, and good drug release and absorption performance, fast onset time, rapid and stable drug effect, can treat psoriasis, tinea manuum, tinea pedis and other skin ringworm and various skin diseases caused by fungi Dermatitis, eczema and other diseases have a good therapeutic effect, but the stability of the drug is not good, and long-term storage will cause a decrease in the content of active ingredients, resulting in a decrease in efficacy
Utilizing the comprehensive effect of stabilizers, the stability of triamcinolone acetonide acetate has been enhanced, so that the content of triamcinolone acetonide acetate urea ointment will not decrease within 2 years and remain stable. Methyl sulfoxide, etc. are irritating to the skin, and long-term use may affect human body functions
Method used
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Embodiment 1～3
[0026] A kind of triamcinolone acetonide acetate emulsifiable paste of embodiment 1~3
[0027] The triamcinolone acetonide acetate cream described in Examples 1-3 is made from the ingredients and parts by weight in Table 1.
[0028] Table 1 Embodiment 1~3 triamcinolone acetonide cream composition and parts by weight
[0029] Element
Example 1
Example 2
Example 3
triamcinolone acetonide acetate
1
1.2
0.5
urea
100
85
90
1
0.8
0.5
10
12
8
Pingpinga A-20
50
60
40
150
160
135
sodium alginate
1
1.5
1
687
679.5
725
[0030] Preparation:
[0031] S1. Put the corresponding amount of urea and propylene glycol in the water phase heating tank, heat to 83°C, stir to dissolve, filter to obtain solution A;
[0032] S2. Filter the corresponding amount of dimethyl sulfoxide wi...
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The invention belongs to the field of pharmaceutical preparations, in particular to a triamcinolone acetonide acetate cream and a preparation method thereof. The cream includes active components and asubstrate. The active components include, by weight, 0.4 to 1.2 parts of triamcinolone acetonide acetate, 80 to 120 parts of urea, 0.5 to 1.2 part of citric acid and 6 to 12 parts of dimethyl sulfoxide. The substrate comprises the following raw materials and parts by weight thereof: 35-62 parts of peregal A-20, 120-180 parts of octadecanol, 630-750 part of propylene glycol and 0.5-1.5 parts of sodium alginate. The cream has strong permeability to skin, quick onset, can be widely used in the treatment of inflammation, pruritus, allergic dermatoses, etc. and has high stability, no irritation tothe intact skin, and strong practicability.
Description
technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to a triamcinolone acetonide acetate cream and a preparation method thereof. Background technique [0002] Triamcinolone acetonide acetate is a long-acting adrenal corticosteroid drug, which has significant anti-inflammatory, anti-allergic and antipruritic effects for external use. Urea is an organic compound composed of carbon, nitrogen and hydrogen. It is a nitrogen-containing metabolite excreted by mammals. It can dissolve glial protein when applied externally. It has anti-itch and antibacterial effects, and can also increase protein hydration and drug transdermal penetration. Clinically, the above two drugs are often used in combination to treat inflammation, pruritus, and allergic skin diseases. [0003] Chinese patent application CN100435801C discloses a medicine for external use for treating skin diseases and a preparation method thereof. The medicine is mainly ma...
Claims
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IPC IPC(8): A61K9/06A61K31/58A61K47/12A61K47/36A61P17/00A61P17/04A61P37/08A61K31/17
CPCA61K9/06A61K31/17A61K31/58A61K47/12A61K47/36A61P17/00A61P17/04A61P37/08A61K2300/00
Inventor 李国成符丽马静
Owner 珠海安生凤凰制药有限公司