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Chinese medicinal composition for preventing and treating proteinuria and application thereof

A composition and proteinuria technology, which is applied in the direction of drug combination, medical preparations containing active ingredients, anti-infective drugs, etc., can solve the problems of high cost, complex extraction process of polysaccharides and peptides, and difficult quality control

Active Publication Date: 2019-01-18
上海复活石医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since the cocoon shell polypeptide and corn silk polysaccharide in this patent are only part of the active ingredients of silkworm cocoon shell and corn silk, but the extraction process of polysaccharide and polypeptide is complicated, and the quality control is difficult, which leads to relatively high cost

Method used

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  • Chinese medicinal composition for preventing and treating proteinuria and application thereof
  • Chinese medicinal composition for preventing and treating proteinuria and application thereof
  • Chinese medicinal composition for preventing and treating proteinuria and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1: oral liquid

[0018] The raw materials are taken according to the following weight ratio: 300 grams of cocoon shells, 300 grams of corn silk, 100 grams of astragalus, 60 grams of salvia miltiorrhiza, and 60 grams of chuanxiong. Add water to decoct the above 5 flavors twice, count from boiling, each time for 1 hour, add 10 times the amount of water for the first time, add 8 times the amount of water for the second time, after the decoction is completed, combine the two decoction liquids, and let cool 3000rpm Centrifuge for 10 minutes, remove the supernatant, concentrate, then add suitable auxiliary materials, make 1L of oral liquid according to the existing known method, and divide it into 10ml per bottle to get it. Oral 3 times a day, 1 bottle each time.

Embodiment 2

[0019] Embodiment 2: Granules

[0020]The raw materials are taken according to the following weight ratio: 300 grams of cocoon shells, 300 grams of corn silk, 100 grams of astragalus, 60 grams of salvia miltiorrhiza, and 60 grams of chuanxiong. Add water to decoct the above 5 flavors twice, count from boiling, each time for 1 hour, add 10 times the amount of water for the first time, add 8 times the amount of water for the second time, after the decoction is completed, combine the two decoction liquids, and let cool 3000rpm Centrifuge for 10 minutes, remove the supernatant, concentrate to an extract with a specific gravity of 1.35, add appropriate amount of dextrin and powdered sugar, dry at 70°C, make granules of 1000 g, granulate, and pack in 5 g per bag to obtain , orally 3 times a day, 1 bag each time.

[0021] The extraction method of sugar-free granules is the same as that of sugar-containing granules. When the extract is prepared into a 1.35 extract, add appropriate am...

Embodiment 3

[0022] Embodiment 3: tablet

[0023] The raw materials are taken according to the following weight ratio: 300 grams of cocoon shells, 300 grams of corn silk, 100 grams of astragalus, 60 grams of salvia miltiorrhiza, and 60 grams of chuanxiong. Add water to decoct the above 5 flavors twice, count from boiling, each time for 1 hour, add 10 times the amount of water for the first time, add 8 times the amount of water for the second time, after the decoction is completed, combine the two decoction liquids, and let cool 3000rpm Centrifuge for 10 minutes, take the supernatant, reduce and concentrate to dry paste, and then make tablets according to the known method in the prior art, each tablet is 0.3 g, orally 3 times a day, 3 tablets each time.

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Abstract

The invention discloses a Chinese medicinal composition for preventing and treating proteinuria. The composition comprises the following raw materials in parts by weight: 1-20 parts of silkworm cocoonshell, 1-20 parts of corn stigma, 0-20 parts of astragalus root, 0-20 parts of salvia miltiorrhiza and 0-20 parts of ligusticum chuanxiong. In addition, the invention also discloses the application of the traditional Chinese medicine composition in preparing medicines and health products for preventing and treating proteinuria. The composition has been proved by animal experiments and clinical trials that the safety is good and the curative effect is good, and the diabetic nephropathy, membranous nephropathy, primary nephritis, IgA nephropathy, purpuric nephritis, lupus nephritis, hypertensive nephropathy and gout can be reduced. Proteinuria caused by different causes such as kidney disease, chronic renal failure, chronic nephritis, nephrotic syndrome, lupus nephritis, urinary tract infection. The traditional Chinese medicine composition is capable of improving clinical symptoms, has small toxic and side effects, has good clinical application prospect, and has simple extraction process, is easy to prepare, and reduces preparation cost.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine compositions, in particular to a traditional Chinese medicine composition for preventing and treating proteinuria and its application. Background technique [0002] Globally, Chronic Kidney Disease (CKD) has been recognized as a major public health problem. According to statistics, in Asia, Europe, Australia and the United States, 10% to 16% of people suffer from chronic kidney disease to varying degrees. Since it takes several years for most patients with chronic kidney disease to gradually transform into the end-stage of chronic renal insufficiency, it is necessary to delay or even reverse the pathological changes of the kidneys in patients with chronic kidney disease. When the kidney is diseased, the permeability of the glomerular filtration membrane is increased, and proteinuria will appear; when the renal tubular reabsorption is dysfunctional, the protein reabsorption ...

Claims

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Application Information

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IPC IPC(8): A61K36/899A61P13/12A61P13/02A61P31/00A61K35/64
CPCA61K35/64A61K36/236A61K36/481A61K36/537A61K36/899A61K35/63A61P13/02A61P13/12A61P31/00A61K2300/00
Inventor 杨茗橘程芬
Owner 上海复活石医药科技有限公司
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