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Method for preparing bionic vascular stent by composite process

A vascular stent and bionic blood vessel technology, which is applied in the directions of blood vessels, human tubular structures, etc., can solve the problems of impossible and difficult to prepare bionic vascular structures, and achieve the effects of simple preparation structure, high structural strength and clear structure.

Active Publication Date: 2021-08-10
SHANGHAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It can be seen from this that different vascular layers have different cell adhesions, and the three-layer vascular stents prepared above basically cannot be inoculated with cells in the middle layer, making it difficult to prepare bionic vascular structures

Method used

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  • Method for preparing bionic vascular stent by composite process
  • Method for preparing bionic vascular stent by composite process
  • Method for preparing bionic vascular stent by composite process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] In this example, see Figure 1-Figure 3 As shown, a method for preparing a bionic vascular stent by a composite process, adopts coaxial electrospinning and coaxial hollow fiber technology to prepare a composite three-layer artificial blood vessel; including the following steps:

[0033] a. If figure 1 As shown, first prepare a rotating shaft, which is used to shape the model of the vascular structure, as a receiving device; it is also possible to control the diameter of the prepared blood vessel by selecting different rotating shafts, such as figure 1 middle(1);

[0034] b. Wrap a layer of 0.2mm thin copper wire on the rotating shaft, and stick the two sections with tape to prevent loosening; it will help to remove the vascular stent later, such as figure 1 in (2);

[0035] c. Prepare the inner layer of blood vessels: Weigh 0.8g of PLA and place it in a beaker, then measure 8ml of dichloromethane and 2ml of dimethylformamide, add them all to the beaker, and wrap them...

Embodiment 2

[0041] This embodiment is basically the same as Embodiment 1, especially in that:

[0042] In this embodiment, a method for preparing a biomimetic vascular stent by a composite process is prepared by coaxial electrospinning of a mixed material to prepare a composite blood vessel of the inner layer, including the following steps:

[0043] a. This step is the same as in Embodiment 1;

[0044] b. This step is the same as in Embodiment 1;

[0045] c. Preparation of the inner layer structure of the blood vessel: Prepared by coaxial electrospun mixed material, that is, weighed 0.8g of PLA and placed it in a beaker, then weighed 8ml of dichloromethane and 2ml of dimethylformamide, Add all of it into the beaker, cover the beaker with tinfoil, let it stand for two hours to let the PLA dissolve completely, then stir it with a glass rod to make the PLA completely dissolve, add it to the syringe, install it on the syringe pump, and supply to the core layer of the coaxial electrospinning...

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Abstract

The invention discloses a method for preparing a bionic vascular stent by a composite process, which is used in the field of biomanufacturing to compositely prepare a vascular stent with a three-layer structure by using coaxial electrospinning technology and coaxial extrusion hollow fiber technology. The vascular stent has three layers Each layer of the layer structure can be inoculated with different types of cells, which has a true bionic human vascular structure; the inner and outer layers can be loaded with drugs, and the middle layer can provide cells with oxygen, nutrients and exclude metabolites; It is beneficial to the growth of blood vessels and shortens the growth cycle of blood vessels, which has broad clinical application prospects.

Description

technical field [0001] The invention relates to a method for preparing a bionic vascular stent, in particular to a method for preparing a bionic three-layer composite vascular stent, which is applied in the technical field of biomanufacturing. Background technique [0002] With the development in recent years, cardiovascular disease has become one of the major diseases that endanger people's life and health. Such as coronary heart disease caused by arteriosclerosis, arterial occlusive disease, blood vessel damage and so on. At present, the main method for treating vascular diseases is blood vessel transplantation. Generally, the best source of blood vessels is autologous blood vessel transplantation, but the source of autologous blood vessels is limited. The main way to solve this difficult problem is to use artificial blood vessels as substitutes, so a large number of artificial blood vessels are used as transplant substitutes in clinical applications. [0003] Due to the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F2/06
CPCA61F2/062
Inventor 胡庆夕刘随红张海光孙程艳李钰苏彩平
Owner SHANGHAI UNIV