Core-shell coaxial nanofibers for repairing periodontitis bone defects, preparation method thereof and use thereof
A technology of nanofibers and nanofiber membranes, applied in the direction of non-active ingredient medical preparations, medical preparations containing active ingredients, pharmaceutical formulas, etc., to achieve good anti-inflammatory effects
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[0046] The specific process of preparing core-shell coaxial nanofibers for repairing periodontitis bone defects is as follows:
[0047] Weigh 5mg of resveratrol and 50mg of Pluronic F127 and fully dissolve in 10ml of absolute ethanol; remove the organic solvent by rotary evaporation to form a thin film, remove the residual organic solvent by vacuum suction overnight, and hydrate with 30ml of deionized water , magnetically stirred at room temperature for 4 hours, filtered through a 0.22 μm filter membrane, and freeze-dried to prepare resveratrol-loaded micelles (RES-PMs). figure 1 and 2 shown.
[0048] See attached image 3 Core-shell coaxial nanofiber membranes loaded with resveratrol and BMP-2 were prepared by coaxial electrospinning, and the 5mL syringes filled with resveratrol micellar solution and BMP-2 solution were respectively fixed on the syringe pump. On the side and the top, connect the nozzle, adjust the distance between the nozzle and the receiving plate, start ...
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