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Neuroprotective agent for delayed brain injury caused by CO poisoning and its application

A neuroprotective agent, a technology for brain injury, applied in the field of medicine, can solve the problems of poor treatment effect, ischemia-reperfusion injury of the nervous system, residual cognitive dysfunction, etc., and achieve the effect of improving cognitive function

Inactive Publication Date: 2019-01-25
朱秀丽
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, excessive oxygenation of hypoxic tissue can still lead to ischemia-reperfusion injury of the nervous system
Therefore, comprehensive treatment is currently the commonly used clinical treatment for CO poisoning delayed brain injury, but the treatment effect is still not good, and a certain degree of cognitive dysfunction is left behind, which leads to the decline in the self-care ability of patients.

Method used

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  • Neuroprotective agent for delayed brain injury caused by CO poisoning and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1 custard apple tablet and its preparation

[0027] Prescription: 200g of custard apple, 214g of starch, 500g of pregelatinized starch, 20g of polyvinylpyrrolidone K25, 6g of potassium sorbate, 150g of talcum powder, 50g of magnesium stearate, 367g of croscarmellose sodium, deionized Appropriate amount of water.

[0028] Preparation: Pass the prescribed amount of custard apple, the prescribed amount of pregelatinized starch, the prescribed amount of polyvinylpyrrolidone K25, the prescribed amount of potassium sorbate and 114g of starch through a 100-mesh sieve, mix them, add deionized water for wet granulation, and dry at 50°C Dry for 2 hours, pass the obtained granules through a 24-mesh sieve, then mix the sieved granules with the remaining starch, the prescribed amount of talcum powder, the prescribed amount of magnesium stearate, and the prescribed amount of croscarmellose sodium, and directly compress them into tablets. 10,000 pieces.

Embodiment 2

[0029] Example 2 Anemone Zhining granule and its preparation

[0030] Prescription: 20 g of custard apple, 30 g of microcrystalline cellulose, 4 g of cross-linked polyvinylpyrrolidone, 1 g of low-substituted hydroxypropyl cellulose, and an appropriate amount of 5% aqueous solution of polyvinylpyrrolidone K30.

[0031] Preparation: pass the prescribed amount of custard apple, microcrystalline cellulose, cross-linked polyvinylpyrrolidone, and low-substituted hydroxypropyl cellulose through a 100-mesh sieve and mix well, add 5% polyvinylpyrrolidone K30 aqueous solution to prepare a soft material, pass 24 Mesh sieve granules, dry at 50°C for 2 hours, pass through a 24 mesh sieve for granulation, and then pack into hard capsule shells to make 1000 capsules.

Embodiment 3

[0032] Example 3 Anemone Ning / Morroniside Compound Tablet and Its Preparation

[0033] Prescription: 200g of custard apple, 2000g of morroniside, 214g of starch, 500g of pregelatinized starch, 2520g of polyvinylpyrrolidone, 6g of potassium sorbate, 150g of talcum powder, 50g of magnesium stearate, croscarmellose sodium 367g, appropriate amount of deionized water.

[0034] Preparation: Pass the prescribed amount of custard apple, the prescribed amount of morroniside, the prescribed amount of pregelatinized starch, the prescribed amount of polyvinylpyrrolidone K25, the prescribed amount of potassium sorbate and 114g of starch through a 100-mesh sieve and mix, add deionized water to wet granulation, dried at 50°C for 2 hours, the resulting granules passed through a 24-mesh sieve, and then mixed with the remaining starch, prescription talcum powder, prescription magnesium stearate, and prescription croscarmellose sodium. Direct compression into 10,000 tablets.

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Abstract

The invention belongs to the field of medicine, in particular to a neuroprotective agent for delayed brain injury caused by CO poisoning and uses thereof. The neuroprotective agent for delayed brain injury due to CO poisoning comprises at least an effective dose of aniline. Among them, annonin can potentially improve the survival rate of hippocampal neurons after CO poisoning, and improve the cognitive behavior of delayed brain injury animals. The neuroprotective agent for delayed brain injury caused by CO poisoning can further comprise other active ingredients with neuroprotective effect, such as edaravone, monoside and the like. The neuroprotective agent for delayed brain injury due to CO poisoning is preferably administered in the gastrointestinal tract.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a neuroprotective agent for CO poisoning delayed brain injury and its application. Background technique [0002] In daily life or industrial production activities, coal and liquefied petroleum gas are widely used. As the main fuel for heating and heating systems, the main gas product of its combustion is carbon dioxide, but when the combustion is insufficient, carbon monoxide (Carbon monoxide, CO) will be produced. After inhalation, the ability of CO to bind with hemoglobin is higher than that of oxygen, so it is easy to reduce the blood supply capacity and cause hypoxic poisoning. Symptoms of poisoning include nausea, dizziness, palpitations, nausea, and coma. Untimely rescue can easily lead to death. [0003] Many organs in the body are highly dependent on oxygen, so CO poisoning can easily cause damage to many organs in the body. Among them, neuron cells in brain tissue...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K31/4152A61K31/4745A61P25/00A61P25/28
CPCA61K31/4152A61K31/4745A61K31/7048A61P25/00A61P25/28A61K2300/00
Inventor 朱秀丽魏姗姗魏群
Owner 朱秀丽
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