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A system and method for detecting volatile organic molecules in exhaled breath

A technology for volatile organic compounds and exhaled gas, which is applied in the direction of measuring devices, analyzing materials, and material analysis through optical means, which can solve the problems of low detection sensitivity and difficult identification of spectral features, so as to improve detection sensitivity and enrichment effect , convenient automatic collection and separation control effect

Active Publication Date: 2020-12-01
HEBEI UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] One of the objectives of the present invention is to provide a detection system for volatile organic molecules in exhaled air, so as to solve the problems of difficult identification of spectral features and low detection sensitivity of existing devices

Method used

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  • A system and method for detecting volatile organic molecules in exhaled breath
  • A system and method for detecting volatile organic molecules in exhaled breath
  • A system and method for detecting volatile organic molecules in exhaled breath

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Embodiment 1

[0058] Such as Figure 1 to Figure 5 As shown, the detection system for volatile organic molecules in exhaled air of the present invention includes an alveolar gas separation system and a gas measurement system. Among them, the alveolar gas separation system includes:

[0059] The ring-down cavity 1 is a cylindrical stainless steel airtight cavity with a diameter of 5 cm and a length of 20 cm. Both ends of the cavity are high-reflectivity mirrors 2 (usually R>99.9%). The air blowing port 3 that enters, the first air outlet 4 for the discharge of dead space gas, the second air outlet 5 for the discharge of alveolar gas, and the pressure monitoring port 6, at the air blowing port 3, the first air outlet 4 and the second air outlet 5 A one-way valve is provided at each place, and a vacuum pump is provided at the first air outlet 4 and the second air outlet 5; a disposable mouthpiece and a filter are provided at the air blowing port 3; a pressure monitoring port 6 is provided wit...

Embodiment 2

[0072] separation of alveolar air

[0073] First, open the one-way valve of the blowing port 3, the subject breathes the lung gas into the ring-down cavity 1 through the disposable mouthpiece, and the pulse laser 7 emits a light source with a pulse repetition frequency of 1KHz, a pulse width of 2~3ns, and an output wavelength of 1573nm, which is the key core technology to enhance the selectivity of the fingerprint spectrum. Through the signal processing and control system 10, the concentration of carbon dioxide entering the gas is monitored in real time online, and the stage of the exhaled air of the human body is judged according to the waveform diagram of carbon dioxide, and then the control Open the corresponding one-way valve to realize the separation of alveolar gas.

[0074] Among them, the gas pressure output device in the control chamber is composed of a pressure sensor, a single-chip microcomputer, a relay and an air extraction system. When the air pressure in the ca...

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Abstract

The invention provides a detection system and method of volatile organic molecules in exhaled air. The detection system of the volatile organic molecules in the exhaled air comprises a alveolar air separation system and an air measurement system; the alveolar air separation system comprises a ring-down chamber, a pulsed laser, a photodetector, and a signal processing and control system; and the air measurement system comprises an air measurement chamber, a transmitter, a detector, a terahertz lens and a signal processing system. The invention uses a near-infrared chamber ring-down spectroscopymeasurement system to realize online real-time separation of dead space air and the alveolar air; the concentration of endogenous VOCs in the alveolar air is two to three times higher than the concentration in the exhaled air sample mixed with the dead space air; and the alveolar air can better reflect the physiological metabolism conditions of a human body; therefore, the invention eliminates the interference of dead air or other ineffective gases, helps to improve the measurement accuracy of characteristic molecules, and greatly improves the detection sensitivity of the system.

Description

technical field [0001] The invention relates to the technical field of gas detection, in particular to a detection system and method for volatile organic molecules in exhaled gas. Background technique [0002] Certain metabolites and chemical substances in the body or blood flow are exchanged between the blood circulatory system and the pulmonary circulatory system in the alveoli, resulting in the composition and concentration of the exhaled gas that can reflect the metabolic function and disease state of the human body. The volatile chemical substances in the exhaled gas of the human body ( As a non-invasive detection technique, the measurement of VOCs is suitable for the screening of precursor patients in healthy people, so it has received more and more attention. It is generally believed that there is a relationship between the measured concentration of the analyte and the extent of the underlying disease. For example, ethanol and acetone in exhaled breath are related to...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/3586G01N21/01
CPCG01N21/01G01N21/3586
Inventor 娄存广刘秀玲荆聪蕊侯凯旋祝伟仝吕林洋王鑫张建涛
Owner HEBEI UNIVERSITY
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