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A double-layer porous biodegradable material coated with active molecules and its preparation method and application

A technology of active molecules and degradable materials, which is applied to double-layer porous biodegradable materials coated with active molecules and the fields of preparation and application thereof, which can solve the problem of single-layer release speed of active molecules, poor stability, unfavorable nutrients or air circulation and other issues, to achieve the effect of improving the effective duration, low cost and controllable quantity

Active Publication Date: 2021-08-27
BLOOMAGE BIOTECHNOLOGY CORP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] In order to solve the problems of poor stability, single degradation rate and release rate of active molecules in the existing materials, the non-porous structure is not conducive to the circulation of nutrients or air, etc.

Method used

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  • A double-layer porous biodegradable material coated with active molecules and its preparation method and application
  • A double-layer porous biodegradable material coated with active molecules and its preparation method and application
  • A double-layer porous biodegradable material coated with active molecules and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Preparation of porous degradable materials coated with antibiotics

[0038] (1) Dissolve hyaluronic acid with a molecular weight of 500 kD and hydroxyethyl cellulose of 1300 kD in purified water and fully dissolve it to prepare a mixed casting solution with a mass concentration of hyaluronic acid and hydroxyethyl cellulose of 1.0%, Use sodium hydroxide solution to adjust the pH value to 12 to obtain an alkaline solution;

[0039] (2) Add epoxy compound crosslinking agent 1,4-butanediol diglycidyl ether 0.2 μl / ml to the alkaline solution, stir evenly, carry out crosslinking at 40°C, and the reaction time is 6h;

[0040] (3) Add a 0.08 µm diameter nano-calcium carbonate solution to the cross-linked polysaccharide solution, disperse evenly, and pour the porogen into a dry mold at a constant temperature of 25°C to form the mass concentration of the porogen at 0.1% to 0.9% (w / v);

[0041] (4) Purify the dried film in ethanol for 48 hours, replace the ethanol every 12 hours,...

Embodiment 2

[0052] Preparation of porous cross-linked films coated with vascular endothelial growth factor and recombinant human epidermal growth factor

[0053] (1) In the four groups of samples A1, A2, B1, and B2, hyaluronic acid with a molecular weight of 1500 kD and carboxymethyl cellulose with a molecular weight of 90 kD were dissolved in 20 mM pH 5.0 phosphate buffer, hyaluronic acid, carboxymethyl cellulose The mass concentration of base cellulose is 2%, 1%;

[0054] (2) Add 0.1mol cross-linking agent carbodiimide to the solution, stir well, and carry out cross-linking reaction at 45°C for 4 hours;

[0055] (3) Add uniformly dispersed 0.1 μm nano-calcium carbonate particles to A1 and A2 samples, and add uniformly dispersed 150 μm paraffin microspheres to B1 and B2 samples, both with a mass concentration of 1%, and dry at a constant temperature of 25°C;

[0056] (4) Purify the film in ethanol for 48 hours, replace the ethanol every 12 hours, then place the film in deionized water f...

Embodiment 3

[0064] Preparation of porous cross-linked hyaluronic acid material coated with non-steroidal anti-inflammatory drugs

[0065] (1) Dissolve hyaluronic acid and carboxymethyl cellulose with a molecular weight of 3000 kD in 20mM phosphate buffer at pH 5.0, and the mass concentrations of hyaluronic acid and carboxymethyl cellulose are 5% and 1.25% respectively;

[0066] (2) Add 1M cross-linking agent carbodiimide to the solution, stir evenly, and carry out cross-linking reaction at 30°C for 8 hours;

[0067] (3) Add 50 µm nano-calcium carbonate particles with a mass concentration of 2% to the solution, disperse evenly, and dry at a constant temperature of 25°C;

[0068] (4) After drying, the cross-linked material was purified in ethanol for 48 hours, and the ethanol was replaced every 12 hours, and then the film was purified in deionized water for 8 hours, and put into a 40-mesh sieve until no liquid flowed down;

[0069] (5) Put the cross-linked porous material after washing awa...

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Abstract

The invention discloses a double-layer porous biodegradable material coated with active molecules. The material is prepared through the following steps: (1) cross-linking hyaluronic acid and natural polysaccharide; (2) adding porogen to the cross-linking solution (3) Repeated purification to wash away the porogen; (4) Immersed in hyaluronic acid solution with specific functional active molecules; (5) Vacuum freeze-drying. The invention has a double-layer structure, the inner layer has a dense structure, good mechanical properties and stability, the outer layer is adhesive when it meets water, both the inner and outer layers carry specific active factors, and has a slow-release effect. And the cost is low, the process cycle is short, the pollution is small, and the energy consumption is low. It can be widely used in many fields such as medicine and cosmetics.

Description

technical field [0001] The invention relates to the technical field of biodegradable new materials, in particular to a porous biodegradable material coated with active molecules and a preparation method thereof, and to the application of the material in medical materials and cell scaffolds. Background technique [0002] Porous materials have interconnected porous structures, which can be prepared into various forms such as thin films, gels, and microspheres. They provide controllable passages for the outside and inside of the material at the same time, and create an environment where nutrients can be exchanged and circulated. It is considered to be the most effective Promising Scaffold Materials for Tissue Engineering. [0003] Hyaluronic acid (Hyaluronic Acid, referred to as HA, also known as hyaluronic acid) is a natural substance widely present in humans and animals. It is a polymer composed of disaccharide units composed of glucuronic acid and acetylhexosamine. Mucopoly...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/28A61L15/42A61L15/62A61L15/44A61K8/02A61K8/73C08J9/26C08J9/28C08J3/24C08L5/08C08L1/28
CPCA61K8/0212A61K8/731A61K8/735A61L15/28A61L15/425A61L15/44A61L15/62A61L2300/216A61L2300/252A61L2300/406A61L2300/41A61L2300/414C08J3/246C08J9/0061C08J9/26C08J9/28C08J2301/28C08J2305/08
Inventor 冯晓毅宋永民宫衍革耿凤郭文逸郭学平
Owner BLOOMAGE BIOTECHNOLOGY CORP LTD
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