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Method for preparing gel ball

A gel ball and coagulator technology, applied in gel preparation, chemical instruments and methods, colloid chemistry, etc., can solve the problems of inaccurate flow rate control, influence of mechanical strength and adsorption performance, large difference in diameter of gel balls, etc.

Inactive Publication Date: 2019-02-12
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The peristaltic pump has low pressure resistance and inaccurate flow rate control, especially when used in high-viscosity polymer material solutions, the actual flow rate is far from the speed displayed by the controller; manual control of the injection, uneven force, resulting in gel balls There is a large difference in diameter, and the amount of gel balls prepared each time is limited by the capacity of the syringe, so it is necessary to replenish the polymer material solution many times
When the cross-linking agent is stored in an ordinary container, due to the gradual reduction of the reaction between the solute and the polymer material, the degree of cross-linking of the gel balls prepared before and after will be different, thus affecting its mechanical strength and adsorption performance

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Use a single-hole drip injector with an aperture of Φ1mm to prepare gel beads for immobilizing keratinase; the pump ① uses a high-performance liquid chromatography pump; the coagulator uses an outer sleeve with an outer diameter of 100mm, a thickness of 10mm, and a height of 50cm; the inner sleeve The outer diameter of the cylinder is 88mm, the thickness is 5mm, and the height is 10cm. There are three separators, with two sorters, the upper separator has a stainless steel screen of 4 mesh, and the lower separator has a stainless steel screen of 10 mesh; the cross-linking agent storage uses a glass beaker; Pump ② chooses ordinary peristaltic pump. The polymer material solution is selected from 0.5%wt sodium alginate solution (i.e. 0.5g sodium alginate is dissolved in 100ml water), and the cross-linking agent is 0.6%wt calcium chloride solution (i.e. 0.6g calcium chloride is dissolved in 100ml water) . The flow rate of pump ① is 1mL / min, and the flow rate of pump ② is 5m...

Embodiment 2

[0042] Use a five-hole drip injector with a pore diameter of Φ50dmm to prepare gel beads for the adsorption of heavy metal ions; the pump ① uses a high-speed countercurrent chromatography pump; the coagulator uses an outer sleeve with an outer diameter of 100mm, a thickness of 10mm, and a height of 50cm; the inner sleeve The outer diameter is 88mm, the thickness is 5mm, and the height is 10cm3. There are two sorters, the upper classifier has a stainless steel screen of 10 mesh, and the lower classifier has a stainless steel screen of 20 mesh; the cross-linking agent storage uses a glass beaker; the pump② Use ordinary peristaltic pumps. The polymer material solution is selected 4%wt sodium alginate solution (i.e. 4g sodium alginate is dissolved in 100ml water) and 1%wt chitosan solution, and cross-linking agent adopts 0.2%wt calcium chloride solution (i.e. 0.2g Calcium chloride dissolved in 100ml of water). Sodium alginate-chitosan composite gel beads with uniform size and hig...

Embodiment 3

[0044] A coaxial double hole drip injector was used to prepare gel beads; two high performance liquid chromatography pumps were selected to supply liquid to the outer hole and the inner hole of the drip injector respectively, and the outer hole provided 0.5%wt chitosan solution, and the inner hole Provide 0.5%wt sodium alginate solution; the coagulator adopts three outer sleeves with an outer diameter of 100mm, a thickness of 10mm, and a height of 50cm; an inner sleeve with an outer diameter of 88mm, a thickness of 5mm, and a height of 10cm. The stainless steel screen of the upper classifier is 4 mesh, and the stainless steel screen of the lower classifier is 10 mesh; the crosslinking agent storage is a glass beaker, and the crosslinking agent is 0.6%wt calcium chloride solution. It can prepare shell-core structure double-layer pellets with uniform size and high mechanical strength. The average particle size of the pellets is 2 mm. Figure 10 shown.

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Abstract

The invention discloses a method used for preparing a gel ball. Preparation is conducted by selecting the following devices: an instillator, a coagulator, classifiers, a crosslinking agent storage, apump and a connection pipe; a solution of a high molecular material (such as sodium alginate, chitosan and gelatin) is added into a solution (such as a calcium chloride solution) containing a crosslinking agent dropwise to make a high molecular compound chain subjected to crosslinking, a compact three-dimensional network structure is formed, and the small gel ball is formed.

Description

technical field [0001] The invention relates to the field of chemical materials, in particular to a device and method for preparing gel balls using polymer materials. Background technique [0002] Functional polymer materials refer to polymer compounds that have specific functions and can be used as functional materials. Among them, sodium alginate, chitosan, gelatin, konjac mannan oligosaccharides, cyclodextrin, collagen, etc. are derived from natural The application of the resulting polymer materials in the fields of medicine and biology has always been a research hotspot. This kind of polymer material can form a gel by cross-linking for drug loading or tissue engineering; when the formed gel is a small ball with a certain mechanical strength, it can be used to embed drugs for slow and controlled release, or It can be used for biotransformation of immobilized cells / enzymes, and can also adsorb heavy metals and pollution. It is widely used in many disciplines such as organ...

Claims

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Application Information

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IPC IPC(8): B01J13/00C08L5/04C08L5/08C08K3/16
CPCB01J13/0065C08K3/16C08K2003/162C08L5/04C08L2205/02C08L5/08
Inventor 钱建瑛史劲松
Owner JIANGNAN UNIV
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